Fátima Liliana Monteiro
University of Aveiro
Histone codeEnhancerCancer epigeneticsGene silencingCellular differentiationEstrogen receptor alphaChemistryGrowth factorMoietyMammary glandBenzimidazoleChalconePalmaria palmataMorphogenesisEpigeneticsCancer researchHistone H2AHistoneNucleosomeBiology
Publications 6
#1Diana LopesH-Index: 7
#2Tânia MeloH-Index: 15
Last. Maria Rosário DominguesH-Index: 27
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4 CitationsSource
#1Amar DjemouiH-Index: 2
#2Abdelkader NaouriH-Index: 2
Last. Artur M. S. Silva (University of Aveiro)H-Index: 46
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Abstract Novel series of triazole-benzimidazole-chalcone hybrid compounds have been synthesized via click chemistry, between different azide derivatives and substituted benzimidazole terminal alkynes bearing a chalcone moiety. The starting alkynes are prepared via base-catalysed nitrogen alkylation of pre-synthetized benzimidazole-chalcone substrates. All the intermediates as well as the final products are fully characterized by 1D and 2D NMR and mass spectrometry techniques. HMBC correlations p...
3 CitationsSource
#2Inês Direito (University of Aveiro)H-Index: 3
Last. Luisa A. HelgueroH-Index: 26
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#1Sebastián Giulianelli (Instituto de Biología y Medicina Experimental)H-Index: 11
#2Marina Riggio (Instituto de Biología y Medicina Experimental)H-Index: 4
Last. Claudia Lanari (Instituto de Biología y Medicina Experimental)H-Index: 24
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: Progression to hormone-independent growth leading to endocrine therapy resistance occurs in a high proportion of patients with estrogen receptor alpha (ERα) and progesterone receptors (PR) positive breast cancer. We and others have previously shown that estrogen- and progestin-induced tumor growth requires ERα and PR interaction at their target genes. Here, we show that fibroblast growth factor 2 (FGF2)-induces cell proliferation and tumor growth through hormone-independent ERα and PR activati...
9 CitationsSource
#1Fátima Liliana Monteiro (University of Aveiro)H-Index: 4
#2Rui Vitorino (University of Aveiro)H-Index: 36
Last. Luisa Ajav. Helguero (University of Aveiro)H-Index: 1
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Abstract Proliferation and differentiation are controlled through chromatin remodelling. Therefore, there is an enormous biological significance and clinical value in understanding how specific signalling pathways are affected by histone replacement in the nucleosome. In this work, mass spectrometry was used to screen HC11 mammary epithelial cells for changes in histone levels throughout cell differentiation. The canonical histone isoform Histone H2A type 2-C ( Hist2h2ac ) was found only in undi...
16 CitationsSource
#1Fátima Liliana Monteiro (University of Aveiro)H-Index: 4
#2Tiago BaptistaH-Index: 10
Last. Luisa A. Helguero (University of Aveiro)H-Index: 26
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// Fatima Liliana Monteiro 1 , Tiago Baptista 2 , Francisco Amado 1 , 3 , Rui Vitorino 1 , Carmen Jeronimo 2,4 and Luisa A. Helguero 1 1 Mass Specrometry Center, Organic Chemistry and Natural Products Unit (QOPNA), Dep. of Chemistry, Universidade de Aveiro., Aveiro, Portugal 2 Cancer Biology & Epigenetics Group, Research Center Portuguese Oncology Institute – Porto. Porto, Portugal 3 School of Health Sciences, Universidade de Aveiro., Portugal 4 Department of Pathology and Molecular Immunology, ...
42 CitationsSource
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