Akifumi Onishi
Okayama University
Survival analysisCardiac function curveInternal medicineSurgeryPathologyOncologyLogistic regressionOdds ratioRenal functionDermatologyRetrospective cohort studyPediatricsProspective cohort studyProbandDNA methylationMedical physicsGenetic analysisArterial stiffnessBiopsyCombination therapyAutoimmune hepatitisFabry diseaseDeoxycytidineHemodialysisAnemiaPulse wave velocityKidney diseasePeritoneal dialysisDiseaseMEDLINECystatin CUrineKidneyCreatinineGlomerulonephritisFibrosisLicenseRenal biopsyNephropathyChronic thyroiditisAutoimmune Polyglandular SyndromeOral prednisoloneCreative commonsPrimary screeningTubulointerstitial fibrosisLong perioda galactosidase aHigh risk patientsOldest oldIntravenous cyclophosphamideLyso gb3Confidence intervalRisk factorDiabetes mellitusVascular resistanceMedical geneticsMedicineCohortTamm–Horsfall proteinBiomarker (medicine)Urinary systemComplicationBlood pressureGastroenterology
11Publications
6H-index
75Citations
Publications 11
Newest
#1Hiroki Maruyama (Niigata University)H-Index: 26
#2Atsumi Taguchi (Niigata University)H-Index: 5
Last. Norio Sakai (Osaka University)H-Index: 37
view all 19 authors...
Fabry disease is an X-linked disorder of α-galactosidase A (GLA) deficiency. Our previous interim analysis (1 July 2014 to 31 December 2015) revealed plasma globotriaosylsphingosine as a promising primary screening biomarker for Fabry disease probands. Herein, we report the final results, including patients enrolled from 1 January to 31 December 2016 for evaluating the potential of plasma globotriaosylsphingosine and GLA activity as a combined screening marker. We screened 5691 patients (3439 ma...
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#1Akifumi Onishi (Okayama University)H-Index: 6
#2Hitoshi Sugiyama (Okayama University)H-Index: 33
Last. Jun Wada (Okayama University)H-Index: 63
view all 13 authors...
Background. Alterations in DNA methylation may be involved in disease progression in patients with chronic kidney disease (CKD). Recent studies have suggested that 5-methyl-2-deoxycytidine (5MedC) may be a marker of hypermethylation of DNA. Currently, there is no information available regarding the urine levels of 5MedC and its association with the progression of CKD. Method. We examined the urine levels of 5MedC in spot urine samples from 308 patients with CKD (median age: 56 years, male: 53.2%...
3 CitationsSource
#1Tomoyo Mifune-Morioka (Okayama University)
#2Haruhito A. Uchida (Okayama University)H-Index: 15
Last. Jun WadaH-Index: 63
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Eight years prior to her present admission, a 61-year-old Japanese woman was diagnosed with autoimmune hepatitis, slowly progressive insulin-dependent diabetes mellitus, and chronic thyroiditis; she had been treated with oral prednisolone (PSL). After she suddenly discontinued PSL, she newly developed systemic lupus erythematosus. A combination therapy of oral PSL and intravenous cyclophosphamide resulted in remission. She was finally diagnosed with autoimmune polyglandular syndrome (APS) type 3...
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#1Hiroki Maruyama (Niigata University)H-Index: 26
#2Kaori Miyata (Genzyme)H-Index: 2
Last. Satoshi IshiiH-Index: 37
view all 31 authors...
2 CitationsSource
#1Hiroki Maruyama (Niigata University)H-Index: 26
#2Kaori MiyataH-Index: 2
Last. Satoshi IshiiH-Index: 37
view all 31 authors...
1 CitationsSource
#1Hiroki Maruyama (Niigata University)H-Index: 26
#2Kaori Miyata (Genzyme)H-Index: 2
Last. Satoshi IshiiH-Index: 9
view all 31 authors...
The HTML version of this Article contained errors in Supplementary Figure S2 “Flowchart of the lyso-Gb3 screening and gene analysis in female patients”, which have been detailed in the associated Correction.
33 CitationsSource
#1Keiko Tanaka (Okayama University)H-Index: 9
#2Hitoshi Sugiyama (Okayama University)H-Index: 33
Last. Jun Wada (Okayama University)H-Index: 63
view all 13 authors...
AIM: Trefoil factor 3 (TFF3) is a small peptide that is involved in mucosal protection. TFF3 is widely expressed in multiple tissues including kidney tissue. Previous studies have reported that the levels of urinary TFF3 are significantly increased in patients with chronic kidney disease. The aim of this study is to detect the TFF3 mRNA in kidney and elucidate the relationship between renal TFF3 mRNA and tubulointerstitial fibrosis in IgA nephropathy (IgAN). METHODS: We investigated the renal mR...
8 CitationsSource
#1Toshio Yamanari (Okayama University)H-Index: 6
#2Hitoshi Sugiyama (Okayama University)H-Index: 33
Last. Jun Wada (Okayama University)H-Index: 63
view all 12 authors...
Introduction. Trefoil factor family (TFF) peptides are increased in serum and urine in patients with chronic kidney disease (CKD). However, whether the levels of TFF predict the progression of CKD remains to be elucidated. Methods. We determined the TFF levels using peptide-specific ELISA in spot urine samples and performed a prospective cohort study. The association between the levels of urine TFFs and other urine biomarkers as well as the renal prognosis was analyzed in 216 CKD patients (mean ...
6 CitationsSource
#1Ayu Ogawa-Akiyama (Okayama University)H-Index: 5
#2Hitoshi SugiyamaH-Index: 33
Last. Jun WadaH-Index: 63
view all 11 authors...
: Cystatin C is a cysteine protease inhibitor that is produced by nearly all human cells. The serum level of cystatin C is a stronger predictor of the renal outcome and the risk of cardiovascular events than the creatinine level. The resistive index (RI) on renal Doppler ultrasonography is a good indicator of vascular resistance as well as the renal outcomes in patients with chronic kidney disease (CKD). However, it is unclear whether serum cystatin C is associated with signs of vascular dysfunc...
8 CitationsSource
#1Keiko TanakaH-Index: 9
#2Masashi KitagawaH-Index: 10
Last. Jun WadaH-Index: 63
view all 11 authors...
Background/Aims: Bleeding is the most common complication after renal biopsy. Although numerous predictors of bleeding have been reported, it remains unclear whether arterial stiffness affects bleeding complications. Method: We performed an observational study of the renal biopsies performed in our division over an approximately 6-year period (May 2010 to May 2016). The clinical and laboratory factors were analyzed to reveal the risk factors associated with bleeding, with a focus on anemia (defi...
7 CitationsSource