Yinu Wang
Northwestern University
CancerDNA damageCellular differentiationChemistryDNA methylationImmunologyTumor microenvironmentChemosensitizerCisplatinTumor initiationTumor progressionALDH1A1Ovarian tumorOvarian cancerHOTAIRStem cellHOX Transcript Antisense RNAEpigeneticsEZH2Cancer researchCancer stem cellLong non-coding RNARNAMedicineBiologyCancer cell
25Publications
8H-index
352Citations
Publications 21
Newest
#1Monal Patel (NU: Northwestern University)H-Index: 8
#2Yinu Wang (NU: Northwestern University)H-Index: 8
Last. Marcus E. Peter (NU: Northwestern University)H-Index: 92
view all 9 authors...
Ovarian cancer remains one of the deadliest gynecologic malignancies affecting women, and development of resistance to platinum remains a major barrier to achieving a cure. Multiple mechanisms have been identified to confer platinum resistance. Numerous microRNAs (miRNAs) have been linked to platinum sensitivity and resistance in ovarian cancer. miRNA activity occurs mainly when the guide strand of the miRNA, with its seed sequence at position 2-7/8, is loaded into the RNA-induced silencing (RIS...
1 CitationsSource
#1Monal Patel (NU: Northwestern University)H-Index: 8
#2Yinu Wang (NU: Northwestern University)H-Index: 8
Last. Marcus E. Peter (NU: Northwestern University)H-Index: 92
view all 9 authors...
Numerous micro(mi)RNAs (short noncoding RNAs that negatively regulate gene expression) have been linked to platinum (Pt) sensitivity and resistance in ovarian cancer (OC). miRNA activity occurs when the guide strand of the miRNA, with its seed sequence (pos. 2-7/8), is loaded into the RNA induced silencing complex (RISC) and targets complementary short seed matches in the 39 untranslated region of mRNAs. Toxic seeds, targeting genes critical for cancer cell survival, have been found in tumor sup...
Source
#1Yinu Wang (NU: Northwestern University)H-Index: 4
#1Yinu Wang (NU: Northwestern University)H-Index: 8
Last. Daniela Matei (NU: Northwestern University)H-Index: 59
view all 14 authors...
Defining traits of platinum-tolerant cancer cells could expose new treatment vulnerabilities. Here, new markers associated with platinum-tolerant cells and tumors were identified using in vitro and in vivo ovarian cancer (OC) models treated repetitively with carboplatin and validated in human specimens. Platinum-tolerant cells and tumors were enriched in ALDH (+) cells, formed more spheroids, and expressed increased levels of stemness-related transcription factors compared to parental cells. Add...
11 CitationsSource
#1Hao Huang (NU: Northwestern University)H-Index: 31
#1Hao Huang (NU: Northwestern University)H-Index: 25
Last. Daniela Matei (NU: Northwestern University)H-Index: 59
view all 11 authors...
N6-Methyladenosine (m6A) is the most abundant modification of mammalian messenger RNAs (mRNA). RNA methylation fine tunes RNA stability and translation, altering cell fate. The fat mass- and obesity-associated protein (FTO) is an m6A demethylase with oncogenic properties in leukemia. Here we show that FTO expression is suppressed in ovarian tumors and cancer stem cells (CSC). FTO inhibited the self-renewal of ovarian CSC and suppressed tumorigenesis in vivo, both of which required FTO demethylas...
20 CitationsSource
#1Hao Huang (NU: Northwestern University)H-Index: 31
#1Hao Huang (NU: Northwestern University)H-Index: 25
Last. Daniela Matei (NU: Northwestern University)H-Index: 59
view all 10 authors...
Introduction: N6-Methyladenosine (m6A) is the most abundant internal modification in mammalian messenger RNAs (mRNAs). Although previous studies have showed that RNA methylation is reversible and plays important roles in various cellular processes, such as metabolism, stem cell development, and self-renewal, its functions in cancer remain elusive. The fat mass- and obesity-associated protein (FTO) is an m6A demethylase and was described as an oncogenic factor in leukemia and brain tumors. We hyp...
Source
#1Yaqi Zhang (NU: Northwestern University)
#2Yinu Wang (NU: Northwestern University)H-Index: 4
Last. Daniela Matei (NU: Northwestern University)H-Index: 59
view all 4 authors...
Cancer stem cells (CSCs) are a specific population of cancer cells that are responsible for tumor initiation, chemoresistance, and metastasis. Previously, our lab has demonstrated ovarian cancer cells with high aldehyde dehydrogenase (ALDH) activities have multiple stem cell-like characteristics, including self-renewal, high clonogenicity, and chemoresistance. Here we identify that H3K79 methyltransferase DOT1L (disruptor of telomeric silencing-1-like) is a critical factor in self-renewal and tu...
Source
#1Yinu WangH-Index: 8
#2Guanyuan ZhaoH-Index: 1
Last. Daniela MateiH-Index: 2
view all 6 authors...
Source
#1Yinu Wang (NU: Northwestern University)H-Index: 8
#1Yinu Wang (NU: Northwestern University)H-Index: 4
Last. Daniela Matei (NU: Northwestern University)H-Index: 59
view all 13 authors...
Defining traits of platinum tolerant cancer cells could expose new treatment vulnerabilities. Here, new markers associated with platinum tolerant cells and tumors were identified by using in vitro and in vivo ovarian cancer (OC) models treated repetitively with carboplatin and validated in human specimens. Platinum-tolerant cells and tumors were found to be enriched in ALDH (+) cells, formed more spheroids, and expressed increased levels of stemness-related transcription factors compared to pare...
3 CitationsSource
#2Salvatore CondelloH-Index: 18
Last. Daniela MateiH-Index: 59
view all 6 authors...
#1Nkechiyere G. Nwani (NU: Northwestern University)H-Index: 4
#2Salvatore Condello (IUPUI: Indiana University – Purdue University Indianapolis)H-Index: 18
Last. Daniela Matei (NU: Northwestern University)H-Index: 59
view all 7 authors...
A small of population of slow cycling and chemo-resistant cells referred to as cancer stem cells (CSC) have been implicated in cancer recurrence. There is emerging interest in developing targeted therapeutics to eradicate CSCs. Aldehyde-dehydrogenase (ALDH) activity was shown to be a functional marker of CSCs in ovarian cancer (OC). ALDH activity is increased in cells grown as spheres versus monolayer cultures under differentiating conditions and in OC cells after treatment with platinum. Here, ...
16 CitationsSource