Anna W. Sobańska
Medical University of Łódź
Analytical chemistryBiological activityDetection limitDensitometryQuantitative structure–activity relationshipMolecular descriptorChemistryThin-layer chromatographyPartition coefficientLipophilicityCalibration curveAvobenzoneAcetonitrileBlood–brain barrierSilica gelMethanolAcetoneNear-infrared spectroscopyChromatographyPhase (matter)Permeation
33Publications
10H-index
140Citations
Publications 33
Newest
Abstract RP-18 TLC chromatography was used to evaluate the pharmacokinetic properties (volume of distribution, VD; plasma protein binding, %PPB; the ability to cross the blood-brain barrier expressed as log PS and log BB) of several cosmetic raw materials – sunscreen and preservatives. The majority of these compounds are intended for topical use on skin and their drug-likeness and the ability to cross biological barriers are undesired. The retention parameters RM0, S, PC1 and RM75 % obtained for...
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#1Anna W. Sobańska (Medical University of Łódź)H-Index: 10
Abstract RP-18 TLC chromatography was used to evaluate the impact on the environment (mobility in soil expressed as soil-water partition coefficient, log Koc; bioconcentration factor in aquatic organisms, log BCF) of several cosmetic raw materials - sunscreens, preservatives and vitamins. The retention parameters RM0 (RM extrapolated to zero concentration of an organic modifier in a mobile phase), S (slope), PC1 (1st principal component) and RM75% (single TLC run parameter for mobile phases cont...
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#1Anna W. SobańskaH-Index: 10
#2Jeremy Robertson (University of Oxford)H-Index: 19
Last. Elżbieta BrzezińskaH-Index: 9
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Several chromatographic parameters (RM0 and S obtained from RP-18 TLC with methanol—pH 7.4 phosphate buffer mobile phases by extrapolation to zero concentration of methanol; Rf and RM obtained from RP-18 TLC with acetonitrile—pH 7.4 phosphate buffer 70:30 v/v as a mobile phase) and calculated molecular descriptors (molecular weight—MW; molar volume—VM; polar surface area—PSA; total count of nitrogen and oxygen atoms—(N+O); H-bond donor count—HD; H-bond acceptor count—HA; distribution coefficient...
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Several newly synthesized or forgotten silica-based stationary phases proposed for liquid chromatography are described, including non-endcapped, short-chain alkyl phases; hydrophilic and polar-endc...
3 CitationsSource
Impregnated thin-layer chromatography (TLC) layers based on silica gel are presented. Impregnating agents such as metal cations, inorganic ions, chelating agents, chiral selectors, surfacta...
2 CitationsSource
#1Anna W. Sobańska (Medical University of Łódź)H-Index: 10
#2Elżbieta Brzezińska (Medical University of Łódź)H-Index: 9
A review of applications of micellar liquid chromatography (MLC) with special stress upon micellar thin layer chromatography (MTLC) in drug discovery is given. MLC and MTLC are presented as valuabl...
6 CitationsSource
#1Anna W. Sobańska (Medical University of Łódź)H-Index: 10
#2Adam Hekner (Medical University of Łódź)H-Index: 1
Last. Elżbieta Brzezińska (Medical University of Łódź)H-Index: 9
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One hundred ten compounds of diverse structures (actives and excipients used in pharmaceutical preparations) were studied by RP-18 HPLC with acetonitrile-pH 7.4 phosphate buffer 1 : 1 (v/v) as the mobile phase. The relationships between the BBB permeation coefficients and the chromatographic parameters log k and (log k)/PSA were compared to those between the blood-brain barrier (BBB) permeation parameters and the RP-18 TLC descriptors Rf and Rf/PSA known from our earlier studies. It was found th...
2 CitationsSource
#1Anna W. Sobańska (Medical University of Łódź)H-Index: 10
#2Karolina Wanat (Medical University of Łódź)H-Index: 3
Last. Elżbieta Brzezińska (Medical University of Łódź)H-Index: 9
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8 CitationsSource
#1Karolina Wanat (Medical University of Łódź)H-Index: 3
#2Elżbieta Brzezińska (Medical University of Łódź)H-Index: 9
Last. Anna W. Sobańska (Medical University of Łódź)H-Index: 10
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: In recent decades, drug-protein interactions have been widely studied and several methods of analysis of these phenomena have been developed and improved. These can be classified into separation, physical, chromatographic and electrophoretic methods. This review depicts the assumptions and mechanisms of methods from each group, details their strengths and weaknesses, and presents examples of their usage from the literature. Equilibrium dialysis, ultrafiltration, Hummel-Dreyer method or high pe...
5 CitationsSource