Sylvie Changotade
University of Paris
OsseointegrationBiomedical engineeringCell migrationPathologyAdsorptionComposite materialChemistryViscoelasticityExtracellular matrixMaterials scienceMesenchymal stem cellIn vitroIn vivoStyreneBiomaterialMaxillary sinusSinus (anatomy)Platelet-rich plasmaFibroblastStem cellConnective tissue metabolismBone regenerationElastomerChemical engineeringTissue engineeringTitaniumConnective tissuePolymerViability assayPorosityMedicineAdhesionProtein adsorptionScaffoldCell biology
23Publications
10H-index
404Citations
Publications 22
Newest
#1S. Lessim (University of Paris)H-Index: 3
#2S. Oughlis (University of Paris)H-Index: 4
Last. Florence Poirier (University of Paris)H-Index: 16
view all 7 authors...
Immediately after surgical placement of biomaterials, a first step consists in the adsorption of proteins from the biological environment on the artificial surfaces. Because the composition of the adsorbed protein layer modulates the cell response to the implanted material, researchers in the biomaterials field have focused on coating proteins or peptides onto surfaces to improve cell response and therefore the long-term compatibility of the implant. However, some materials used in tissue engine...
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By using a high internal phase emulsion process, elastomeric poly(e-caprolactone urethane) (PCLU) scaffolds were designed with pores size ranging from below 150 μm to 1800 μm and a porosity of 86% making them suitable for bone tissue engineering applications. Moreover, the pores appeared to be excellently interconnected, promoting cellularization and future bone ingrowth. This study evaluated the in vitro cytotoxicity of the PCLU scaffolds towards human mesenchymal stem cells (hMSCs) through the...
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#1Helena P. Felgueiras (University of Paris)H-Index: 15
#2L. Castanheira (ECP: École Centrale Paris)H-Index: 1
Last. Didier Lutomski (University of Paris)H-Index: 16
view all 14 authors...
The purpose of this study was to investigate the relationship between the osteoblastic cells behavior and biotribocorrosion phenomena on bioactive titanium (Ti). Ti substrates submitted to bioactive anodic oxidation and etching treatments were cultured up to 28 days with MG63 osteoblast-like cells. Important parameters of in vitro bone-like tissue formation were assessed. Although no major differences were observed between the surfaces topography (both rough) and wettability (both hydrophobic), ...
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#1Raed Lattouf (""St. Joe's"": Saint Joseph's University)H-Index: 2
#2Ronald Younes (""St. Joe's"": Saint Joseph's University)H-Index: 4
Last. Sylvie Changotade (Sorbonne)H-Index: 10
view all 7 authors...
Specific staining of the extracellular matrix components is especially helpful in studying tissue remodeling, particularly in the case of connective tissue pathologies. As developed by Junqueira and colleagues in 1979, specific staining by Picrosirius red is one of the most important stains to study collagen networks in different tissues. Under polarized light, collagen bundles appear green, red or yellow, and are easily differentiated from the black background, thus allowing for quantitative mo...
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#1Karim Senni (Paris V: Paris Descartes University)H-Index: 12
#2Farida GuenicheH-Index: 5
Last. Sylvia Colliec-JouaultH-Index: 25
view all 10 authors...
Biopolymers produced by marine organisms can offer useful tools for regenerative medicine. Particularly, HE800 exopolysaccharide (HE800 EPS) secreted by a deep-sea hydrothermal bacterium displays an interesting glycosaminoglycan-like feature resembling hyaluronan. Previous studies demonstrated its effectiveness to enhance in vivo bone regeneration and to support osteoblastic cell metabolism in culture. Thus, in order to assess the usefulness of this high-molecular weight polymer in tissue engine...
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#1Véronique Migonney (Sorbonne)H-Index: 25
#2I. Ben Aissa (Sorbonne)H-Index: 1
Last. Azzam Saleh-MghirH-Index: 12
view all 16 authors...
Abstract The project ANR TECSAN “ACTISURF” has for main objective to propose a new generation of joint prosthesis (hip, knee, shoulder) made of TAl6V titanium alloy capable of limiting and even preventing the joint infections. A chemical modification of titanium surfaces has been set up to confer desirable functional and required properties to the joint prostheses. In order to prevent bacteria adhesion and to improve the long-term osteointegration, bioactive polymers bearing ionic groups were co...
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#1J. Bassil (""St. Joe's"": Saint Joseph's University)H-Index: 2
#2Nada Naaman (""St. Joe's"": Saint Joseph's University)H-Index: 13
Last. Gaston Godeau (University of Paris)H-Index: 33
view all 8 authors...
The aim of the present study was to evaluate bone formation after maxillary sinus augmentation using bovine bone substitute material Bio-Oss alone by means of clinical, histological, and histomorph...
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#1S. Oughlis (University of Paris)H-Index: 4
#2S. Lessim (University of Paris)H-Index: 3
Last. Didier Lutomski (University of Paris)H-Index: 16
view all 10 authors...
Osseointegration of metallic implants used in orthopedic surgery requires that osteoprogenitor cells attach and adhere to the surface, then proliferate, differentiate into osteoblasts, and finally produce mineralized matrix. Because the ability of progenitor cells to attach to a scaffold surface during early stages is important in the development of new tissue structures, we developed in our laboratory, a strategy involving grafting of implants with a polymer of sodium styrene sulfonate (polyNaS...
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#1S. Lessim (University of Paris)H-Index: 3
#2Véronique MigonneyH-Index: 25
Last. Sylvie ChangotadeH-Index: 10
view all 5 authors...
Abstract Introduction of a new generation of artificial ligaments for ACL reconstruction, the Ligament Augmentation and Reconstruction System (LARS), gives promising clinical results [1]. The current literature supports the use of LARS from short to medium term. To go even further to improve the biocompatibility of this biomaterial, poly(sodium styrene sulfonate) (polyNaSS) was grafted onto its surface. Studies using sheep animal model showed improvement of knee functionalities with this grafted...
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#1S. Oughlis (University of Paris)H-Index: 4
#2S. Lessim (University of Paris)H-Index: 3
Last. Didier Lutomski (University of Paris)H-Index: 16
view all 9 authors...
It is known that protein adsorption is the initial interaction between implanted biomaterials and biological environment. Generally, a complex protein layer will be formed on material surfaces within a few minutes and the composition of this layer at the interface determines the biological response to the implanted material, and therefore the long-term compatibility of the biomaterial. Despite different techniques exist to observe protein adsorption on biomaterials, none of them led to the ident...
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