Matthias Taupitz
RadiologyPathologyMagnetic resonance imagingNanoparticleChemistryMaterials scienceIn vivoProstateContrast (vision)Magnetic resonance angiographyVSOPContrast mediumProstate cancerMr imagingNuclear medicineSuperparamagnetic iron oxideBlood poolNuclear magnetic resonanceImage qualityMedicine
Publications 162
#4Jan O. Kaufmann (BAM: Bundesanstalt für Materialforschung und -prüfung)H-Index: 3
Atherosclerosis is a progressive inflammatory vascular disease characterized by endothelial dysfunction and plaque burden. Extracellular matrix (ECM)-associated plasma proteins play an important role in disease development. Our magnetic resonance imaging (MRI) study investigates the feasibility of using two different molecular MRI probes for the simultaneous assessment of ECM-associated intraplaque albumin deposits caused by endothelial damage and progressive inflammation in atherosclerosis. Mal...
#1Chie-Hee Cho (Charité)H-Index: 1
#2Grosse-Siestrup C (Charité)H-Index: 8
Last. Peter SchlattmannH-Index: 52
view all 8 authors...
Exposure to radiofrequency (RF) power deposition during magnetic resonance imaging (MRI) induces elevated body-tissue temperatures and may cause changes in heart and breathing rates, disturbing thermoregulation. Eleven temperature sensors were placed in muscle tissue and one sensor in the rectum (measured in 10 cm depth) of 20 free-breathing anesthetized pigs to verify temperature curves during RF exposure. Tissue temperatures and heart and breathing rates were measured before, during, and after...
#1Patrick Asbach (Charité)H-Index: 26
#2Matthias Taupitz (Charité)H-Index: 40
Die Magnetresonanztomographie nimmt bei der Therapieplanung des Rektumkarzinoms eine Schlusselrolle ein, da sie prazise nicht nur die lokale Ausdehnung und die anatomische Lagebeziehung des Rektumkarzinoms zu Schlusselstrukturen abbilden kann, sondern auch prognoserelevante Information generieren kann und damit direkt die Wahl des optimalen therapeutischen Prozedere fur den jeweiligen Patienten beeinflusst. Dabei mussen zwei Regimen gegeneinander abgewogen werden. Wird eine eher radikale Therapi...
#1Wolfgang Poller (Charité)H-Index: 55
#2Carsten Skurk (Charité)H-Index: 22
Last. Ulf Landmesser (Charité)H-Index: 104
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Abstract Cardiac amyloidosis is associated with very high morbidity and mortality. Only if treated early, cardiac amyloidosis responds well to therapy, and early recognition with a full differential diagnostic workup including multimodality imaging is therefore critical at first presentation. Closely meshed clinical monitoring and imaging are indispensable to ensure optimal individualized treatment. (Level of Difficulty: Beginner.)
1 CitationsSource
#1Shuangqing Wang (Humboldt University of Berlin)H-Index: 2
#2Bernhard Hesse (European Synchrotron Radiation Facility)H-Index: 16
Last. Carmen Infante-Duarte (Humboldt University of Berlin)H-Index: 5
view all 14 authors...
ObjectivesThe aim of this study was to determine in vivo if brain inflammation leads to increased gadolinium (Gd) retention in brain tissue after repeated applications of Gd-based contrast agents (GBCAs).Materials and MethodsExperimental autoimmune encephalomyelitis (EAE) was induced in female SJL/J
17 CitationsSource
#1Katharina Erb-Eigner (Charité)H-Index: 7
#2Patrick Asbach (Charité)H-Index: 26
Last. Rüdiger Lawaczeck (Bayer AG: Bayer HealthCare Pharmaceuticals)H-Index: 3
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BackgroundDifferentiating benign from malignant orbital lesions by imaging and clinical presentation can be challenging.PurposeTo differentiate benign from malignant orbital masses using dynamic co...
5 CitationsSource
#1Wolfram C. Poller (Humboldt University of Berlin)H-Index: 11
#2Melanie Pieber (Humboldt University of Berlin)H-Index: 1
Last. Antje Ludwig (Humboldt University of Berlin)H-Index: 14
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Abstract We investigated the biotransformation of very small superparamagnetic iron oxide nanoparticles (VSOP) in atherosclerotic LDLR−/− mice. Transmission electron microscopy revealed an uptake of VSOP not only by macrophages but also by endothelial cells in liver, spleen, and atherosclerotic lesions and their accumulation in the lysosomal compartment. Using magnetic particle spectroscopy (MPS), we show that the majority of VSOP's superparamagnetic iron was degraded within 28 days. MPS spectru...
21 CitationsSource
#1G Jörn (Charité)
#2Florian Nino Loch (Charité)H-Index: 2
Last. Martin E. Kreis (Charité)H-Index: 18
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#1Harald Kratz (Charité)H-Index: 8
#2Matthias Taupitz (Charité)H-Index: 40
Last. Jörg Schnorr (Charité)H-Index: 23
view all 9 authors...
Synthesis of novel magnetic multicore particles (MCP) in the nano range, involves alkaline precipitation of iron(II) chloride in the presence of atmospheric oxygen. This step yields green rust, which is oxidized to obtain magnetic nanoparticles, which probably consist of a magnetite/maghemite mixed-phase. Final growth and annealing at 90°C in the presence of a large excess of carboxymethyl dextran gives MCP very promising magnetic properties for magnetic particle imaging (MPI), an emerging medic...
32 CitationsSource
#1Angela Ariza de Schellenberger (Charité)H-Index: 7
#2Judith W.J. Bergs (Charité)H-Index: 11
Last. Matthias Taupitz (Charité)H-Index: 40
view all 4 authors...
All tissues and organs are composed of cells and extracellular matrix (ECM). The components of the ECM have important functional and structural roles in tissues. On the one hand, the ECM often dominates the biomechanical properties of soft tissues and provides mechanical support to the tissue. On the other hand, ECM components maintain tissue homeostasis, pH, and hydration of the micromilieu and, via signal transduction, also play a key role in ECM-cell interactions which in turn control cell mi...
2 CitationsSource