Euteum Park
Chosun University
Internal medicineEndocrinologyUnfolded protein responsemicroRNAGene expressionMolecular biologyEndoplasmic reticulumTumor necrosis factor alphaChemistryApoptosisOxidative stressNitric oxide synthaseCurcuminCytokineLipopolysaccharideNeurotoxicitySodium nitroprussideDopaminergic CellProgrammed cell deathReactive oxygen speciesCancer researchNitric oxideViability assayGlutathioneTransfectionBiochemistryBiologyCell biologyCancer cellProtein kinase APharmacology
Publications 15
#1Euteum ParkH-Index: 7
#2Do Kyung KimH-Index: 13
Last. Hong Sung ChunH-Index: 18
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Fusidic acid, a steroidal antibiotic, possesses antimicrobial, antioxidant, and anti-inflammatory properties, but the effect of fusidic acid against neurodegenerative disease-related cell death has not been studied. Here, we investigated the protective effects of fusidic acid on sodium nitroprusside (SNP)-induced toxicity in C6 glial cells. Fusidic acid (5-20 muM) prevented SNP (100 muM)-induced cell death dose dependently, and effectively attenuated SNP-induced generation of nitric oxide (NO), ...
1 CitationsSource
#1Euteum Park (Chosun University)H-Index: 7
#2Jungsoo Gim (Chosun University)H-Index: 9
Last. Hong Sung Chun (Chosun University)H-Index: 18
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: Glutamate-mediated cytotoxicity has been implicated in the pathogenesis of neurological diseases, including Parkinson's disease, Alzheimer's disease, and stroke. In this study, we investigated the protective effects of alpha-lipoic acid (ALA), a naturally occurring thiol antioxidant, on glutamate-induced cytotoxicity in cultured C6 astroglial cells. Exposure to high-dose glutamate (10 mM) caused oxidative stress and mitochondrial dysfunction through the elevation of reactive oxygen species, de...
8 CitationsSource
#1Euteum Park (Chosun University)H-Index: 7
#2Hong Sung Chun (Chosun University)H-Index: 18
: Curcumin, a bioactive component in tumeric, has been shown to exert antioxidant, anti-inflammatory, anticarcinogenic, hepatoprotective, and neuroprotective effects, but the effects of curcumin against manganese (Mn)-mediated neurotoxicity have not been studied. This study examined the protective effects of curcumin on Mn-induced cytotoxicity in BV-2 microglial cells. Curcumin (0.1-10 µM) dose-dependently prevented Mn (250 µM)-induced cell death. Mn-induced mitochondria-related apoptotic charac...
9 CitationsSource
#1Euteum Park (Chosun University)H-Index: 7
#2Hong Sung Chun (Chosun University)H-Index: 18
Melatonin, a naturally occurring neurohormone in the pineal gland, has been shown to exert antioxidant and anti-inflammatory effects. This study examined the effects of melatonin on manganese (Mn) and/or lipopolysaccharide (LPS)-induced microglial activation. Melatonin (10 μM) inhibited Mn (100 μM) and/or LPS (0.5 μg/ml)-induced phagocytotic activity of activated BV2 microglia. It also inhibited the lipid peroxidation and intracellular reduced glutathione (GSH) depletion induced by Mn and/or LPS...
19 CitationsSource
Dieldrin, an organochlorine pesticide still used in several developing countries, has been proposed as a risk factor for Parkinson's disease. Quercetin is one of the potent bioactive flavonoids present in numerous plants. In this study, we investigated the protective effects of quercetin on neurotoxicity induced by dieldrin in cultured dopaminergic SN4741 cells. Our initial experiments showed that quercetin (10-40 μM) dose dependently prevented dieldrin (20 μM)-induced cytotoxicity in SN4741 cel...
8 CitationsSource
#1Euteum Park (Chosun University)H-Index: 7
#2Kyoung Hwan Yu (Chosun University)H-Index: 1
Last. Hong Sung Chun (Chosun University)H-Index: 18
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Monosodium glutamate (MSG) is a flavor enhancer, largely used in the food industry and it was reported to have excitotoxic effects. Higher amounts of MSG consumption have been related with increased risk of many diseases, including Chinese restaurant syndrome and metabolic syndromes in human. This study investigated the protective effects of N-acetylcysteine (NAC) on MSG-induced cytotoxicity in C6 astrocytic cells. MSG (20 mM)-induced reactive oxygen species (ROS) generation and apoptotic cell d...
17 CitationsSource
#1Jae-Sung Kim (Chosun University)H-Index: 24
#2Sun-Kyoung Yu (Chosun University)H-Index: 10
Last. Do Kyung Kim (Chosun University)H-Index: 23
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MicroRNA (miRNA) is a form of small noncoding RNA that regulates the expression of genes either by inhibiting mRNA translation or by inducing its degradation. Small microRNA play important roles in regulating a large number of cellular processes, including development, proliferation and apoptosis. This study examined the biological functions of miR-205 as a tumor suppressor in KB oral cancer cells. The results showed that miR-205 expression was significantly lower in KB oral cancer cells than in...
45 CitationsSource
#1Hyun-Sang Jeon (Chosun University)H-Index: 2
#2Myung-Hun Jo (Chosun University)H-Index: 1
Last. Do Kyung Kim (Chosun University)H-Index: 23
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Effects of diphenyl difluoroketone (EF-24) and curcumin on cell growth and apoptosis induction in KB human oral cancer cells were examined. EF-24 and curcumin inhibited the growth of KB cells in a dose-dependent manner, and the potency of EF-24 was 30 times greater than that of curcumin. Treatment with EF-24 or curcumin resulted in nuclear condensation and fragmentation. EF-24 and curcumin promoted the proteolytic cleavage of procaspases-3, -7, and -9. Activities of caspases-3 and -7 were detect...
6 CitationsSource
#1Min-Gyeong ParkH-Index: 6
#2Myoung-Hwa LeeH-Index: 7
Last. Do Kyung KimH-Index: 13
view all 10 authors...