Andrea Ferrero
Mayo Clinic
Imaging phantomOpticsPhysicsRadiologyPET-CTBiomedical engineeringIterative reconstructionArtificial intelligenceTomographyProjection (set theory)Materials scienceImage resolutionPositron emission tomographyScannerNuclear medicinePhoton counting detectorComputer visionMathematicsComputer scienceComputed tomographyResolution (electron density)MedicineFragilityDetector
41Publications
8H-index
215Citations
Publications 41
Newest
#1Roy P. Marcus (Mayo Clinic)H-Index: 14
#1Roy P. Marcus (Mayo Clinic)H-Index: 2
Last. Cynthia H. McColloughH-Index: 76
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The evaluated photon-counting–detector CT system has the potential to improve the automatic characterization of small stones (≤3 mm).
19 CitationsSource
#1Wei Zhou (Mayo Clinic)H-Index: 13
#2Rachel Schornak (Mayo Clinic)H-Index: 1
Last. Shuai Leng (Mayo Clinic)H-Index: 53
view all 9 authors...
Photon counting detector (PCD) based multi-energy CT is able to generate different types of images such as virtual monoenergetic images (VMIs) and material specific images (e.g., iodine maps) in addition to the conventional single energy images. The purpose of this study is to determine the image type that has optimal iodine detection and to determine the lowest detectable iodine concentration using a PCD-CT system. A 35 cm body phantom with iodine inserts of 4 concentrations and 2 sizes was sca...
5 CitationsSource
#1Andrea Ferrero (Mayo Clinic)H-Index: 8
#2Ken Fetterly (Mayo Clinic)H-Index: 1
Last. Beth A. Schueler (Mayo Clinic)H-Index: 32
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Our institution routinely uses limited-angle cone-beam CT (CBCT) from a C-arm with 3D capabilities to diagnose and treat cardiovascular and orthopedic diseases in both adult and pediatric patients. While CBCT contributes to qualitative and quantitative assessment of both normal and abnormal patient anatomy, it also contributes substantially to patient radiation dose. Reducing the dose associated with CBCT exams while maintaining clinical utility can be considered to be of benefit to patients for...
2 CitationsSource
#1Andrea Ferrero (Mayo Clinic)H-Index: 8
#2Ralf Gutjahr (TUM: Technische Universität München)H-Index: 7
Last. Cynthia H. McCollough (Mayo Clinic)H-Index: 76
view all 5 authors...
Rational and Objectives This study aims to investigate the performance of a whole-body, photon-counting detector (PCD) computed tomography (CT) system in differentiating urinary stone composition. Materials and Methods Eighty-seven human urinary stones with pure mineral composition were placed in four anthropomorphic water phantoms (35–50 cm lateral dimension) and scanned on a PCD-CT system at 100, 120, and 140 kV. For each phantom size, tube current was selected to match CTDIvol (volume CT dose...
8 CitationsSource
#1Wei Zhou (Mayo Clinic)H-Index: 13
#2J. Montoya (Mayo Clinic)H-Index: 4
Last. Shuai Leng (Mayo Clinic)H-Index: 53
view all 8 authors...
An ultra-high resolution (UHR) mode, with a detector pixel size of 0.25 mm×0.25 mm relative to isocenter, has been implemented on a whole body research photon-counting detector (PCD) computed tomography (CT) system. Twenty synthetic lung nodules were scanned using UHR and conventional resolution (macro) modes and reconstructed with medium and very sharp kernels. Linear regression was used to compare measured nodule volumes from CT images to reference volumes. The full-width-at-half-maximum of th...
11 CitationsSource
#1Christopher P. Favazza (Mayo Clinic)H-Index: 24
#2Andrea Ferrero (Mayo Clinic)H-Index: 8
Last. Cynthia H. McCollough (Mayo Clinic)H-Index: 76
view all 6 authors...
The use of iterative reconstruction (IR) algorithms in CT generally decreases image noise and enables dose reduction. However, the amount of dose reduction possible using IR without sacrificing diagnostic performance is difficult to assess with conventional image quality metrics. Through this investigation, achievable dose reduction using a commercially available IR algorithm without loss of low contrast spatial resolution was determined with a channelized Hotelling observer (CHO) model and used...
6 CitationsSource
#1Andrea Ferrero (Mayo Clinic)H-Index: 8
#2Baiyu Chen (Mayo Clinic)H-Index: 13
Last. Cynthia H. McCollough (Mayo Clinic)H-Index: 76
view all 5 authors...
Purpose To compare algorithms performing material decomposition and classification in dual-energy CT, it is desirable to know the ground truth of the lesion to be analyzed in real patient data. In this work, we developed and validated a framework to insert digital lesions of arbitrary chemical composition into patient projection data acquired on a dual-source, dual-energy CT system. Methods A model that takes into account beam-hardening effects was developed to predict the CT number of objects w...
2 CitationsSource
#1Andrea Ferrero (Mayo Clinic)H-Index: 8
#2Christopher P. Favazza (Mayo Clinic)H-Index: 24
Last. Cynthia H. McCollough (Mayo Clinic)H-Index: 76
view all 5 authors...
Fundamental to the development and application of channelized Hotelling observer (CHO) models is the selection of the region of interest (ROI) to evaluate. For assessment of medical imaging systems, reducing the ROI size can be advantageous. Smaller ROIs enable a greater concentration of interrogable objects in a single phantom image, thereby providing more information from a set of images and reducing the overall image acquisition burden. Additionally, smaller ROIs may promote better assessment...
5 CitationsSource
#1Wei Zhou (Mayo Clinic)H-Index: 13
#2J. Montoya (Mayo Clinic)H-Index: 4
Last. Shuai Leng (Mayo Clinic)H-Index: 53
view all 8 authors...
A new ultra high-resolution (UHR) mode has been implemented on a whole body photon counting-detector (PCD) CT system. The UHR mode has a pixel size of 0.25 mm by 0.25 mm at the iso-center, while the conventional (macro) mode is limited to 0.5 mm by 0.5 mm. A set of synthetic lung nodules (two shapes, five sizes, and two radio-densities) was scanned using both the UHR and macro modes and reconstructed with 2 reconstruction kernels (4 sets of images in total). Linear regression analysis was perfor...
2 CitationsSource
#1Andrea Ferrero (Mayo Clinic)H-Index: 8
#2Ralf Gutjahr (TUM: Technische Universität München)H-Index: 7
Last. C McCollough (Mayo Clinic)H-Index: 5
view all 10 authors...
In addition to the standard-resolution (SR) acquisition mode, a high-resolution (HR) mode is available on a research photon-counting-detector (PCD) whole-body CT system. In the HR mode each detector consists of a 2x2 array of 0.225 mm x 0.225 mm subpixel elements. This is in contrast to the SR mode that consists of a 4x4 array of the same subelements, and results in 0.25 mm isotropic resolution at iso-center for the HR mode. In this study, we quantified ex vivo the capabilities of the HR mode to...
4 CitationsSource