Guangxi Zhai
Shandong University
MicellePharmacokineticsTargeted drug deliveryDrug carrierNuclear chemistrySolubilityNanoparticleNanotechnologyBioavailabilityNanocarriersChemistryMaterials scienceIn vivoCurcuminDrug deliveryDrugChromatographyCancer researchZeta potentialPharmacology
153Publications
45H-index
5,742Citations
Publications 152
Newest
#1Qiu Na (SDU: Shandong University)
#2Du Xiyou (SDU: Shandong University)
Last. Guangxi Zhai (SDU: Shandong University)H-Index: 45
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Despite a potential drug with multiple pharmacological activities, curcumin has disadvantages of the poor water solubility, rapid metabolism, low bioavailability, which considerably limit its clinical application. Currently, polymeric micelles (PMs) have gained widespread concern due to their advantageous physical and chemical properties, easy preparation, and biocompatibility. They can be used to improve drug solubility, prolong blood circulation time, and allow passive targeted drug delivery t...
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#1Hang Wu (SDU: Shandong University)
#2Xianglei Fu (SDU: Shandong University)
Last. Guangxi Zhai (SDU: Shandong University)H-Index: 45
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To solve the problems of high toxicity and poor efficacy of existing tumor treatment methods, researchers have developed a variety of tumor immunotherapies. Among them, tumor vaccines activate antigen-presenting cells and T lymphocytes upstream of the cancer-immunity cycle are considered the most promising therapy to activate the immune system. Nanocarriers are considered the most promising tumor vaccine delivery vehicles, including polymer nanocarriers, lipid nanocarriers, inorganic nanocarrier...
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#1Shangui Liu (SDU: Shandong University)
#2Abdur Rauf Khan (SDU: Shandong University)H-Index: 9
Last. Guangxi Zhai (SDU: Shandong University)H-Index: 45
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Multidrug resistance (MDR) of cancer is a persistent problem in chemotherapy. Scientists have considered the overexpressed efflux transporters responsible for MDR and chemotherapy failure. MDR extremely limits the therapeutic effect of chemotherapy in cancer treatment. Many strategies have been applied to solve this problem. Multifunctional nanoparticles may be one of the most promising approaches to reverse MDR of tumor. These nanoparticles can keep stability in the blood circulation and select...
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#1Xinru Kong (SDU: Shandong University)
#2Jiangkang Xu (SDU: Shandong University)H-Index: 5
Last. Guangxi Zhai (SDU: Shandong University)H-Index: 45
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Since the discovery of cell-penetrating peptides (CPP) in the 1980s, they have played a unique role in various fields owing to their excellent and unique cell membrane penetration function. In particular, in the treatment of tumours, CPPS have been used to deliver several types of 'cargos' to cancer cells. To address the insufficient targeting ability, non-selectivity, and blood instability, activatable cell-penetrating peptides, which can achieve targeted drug delivery in tumour treatment, enha...
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#1Yimu LiH-Index: 1
#1Yimu Li (SDU: Shandong University)H-Index: 4
Last. Guangxi ZhaiH-Index: 45
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#1Yanan ZhangH-Index: 4
#2Na QiuH-Index: 1
Last. Guangxi ZhaiH-Index: 45
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Sonodynamic therapy (SDT) is a promising non-invasive approach for cancer therapy. However, tumor hypoxia, a pathological characteristic of most solid tumor types, poses a major challenge in the application of SDT. In this study, a novel CD44 receptor-targeted and redox/ultrasound-responsive oxygen-carrying nanoplatform was constructed using chondroitin sulfate (CS), reactive oxygen species (ROS)-generating sonosensitizer Rhein (Rh), and perfluorocarbon (PFC). Perfluoroalkyl groups introduced in...
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#1Rong Wang (SDU: Shandong University)H-Index: 1
#2Huixian Yan (SDU: Shandong University)H-Index: 1
Last. Guangxi Zhai (SDU: Shandong University)H-Index: 45
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Abstract Till now, cancer is one of the most serious diseases causing a high death ratio and a huge challenge to human health. Nanocarriers with the advantages of improved bioavailability and targeting property are one of the safe and effective approaches for cancer treatment. However, the traditional nanocarriers still face various challenges in clinical applications, such as strong cytotoxicity, easy to be recognized and removed by the immune system, and poor ability to penetrate cell membrane...
1 CitationsSource
#1Rujuan Wang (SDU: Shandong University)H-Index: 2
#2Haotong Yang (SDU: Shandong University)H-Index: 3
Last. Guangxi Zhai (SDU: Shandong University)H-Index: 45
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Abstract Specific cellular uptake and sufficient drug release in tumor tissues are important for effective cancer therapy. Hyaluronic acid (HA), a skeleton material, could specifically bind to cluster determinant 44 (CD44) receptors highly expressed on the surface of tumor cells to realize active targeting. Cystamine (cys) is sensitive highly reductive environment inside tumor cells and was used as a connecting arm to connect docosahexaenoic acid (DHA) and chlorin e6 (Ce6) to the HA skeleton to ...
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#1Yuelin Fang (SDU: Shandong University)
#2Aihua Yu (SDU: Shandong University)H-Index: 1
Last. Guangxi Zhai (SDU: Shandong University)H-Index: 45
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INTRODUCTION Compared with traditional cancer treatment methods, tumor-targeted immunotherapy can combine targeted therapy and immunotherapy with long-lasting responses to achieve synergistic therapy, which brings hope to the complete cure of cancer. AREAS COVERED This review summarizes the newest and most up-to-date advances in tumor-targeted immunotherapy, including tumor-associated macrophages (TAMs) targeted immunotherapy, regulatory T (Treg) cells targeted immunotherapy, tumor-associated fi...
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#1Yimu Li (Fudan University)H-Index: 1
#2Xuling Chen (SDU: Shandong University)H-Index: 1
Last. Guangxi Zhai (SDU: Shandong University)H-Index: 45
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Abstract In this paper, a novel redox-responsive nanoparticles has been designed for targeted delivery of docetaxel (DTX). Chondroitin sulfate (CS) was used to construct the nanoparticles due to the ability of tumor targeting through binding with CD44 receptor that overexpresses on the surfaces of various tumor cells. A redox-responsive small-molecular DTX prodrug was prepared through modifying with cystamine containing disulfide bonds (Cys-DTX). Then the DTX prodrug was grafted to the CS to con...
1 CitationsSource