Jose Serrano
National Institutes of Health
Internal medicineEndocrinologySurgeryPathologyReceptorIntensive care medicineProspective cohort studyImmunohistochemistryPancreatitisLiver injuryLiver diseaseZollinger-Ellison syndromePancreasInsulinLiver transplantationDrugGastrinomaIn patientCancer researchMedicineBiologyGastroenterology
Publications 108
#1Raj Vuppalanchi (IU: Indiana University)H-Index: 43
#2Herbert L. Bonkovsky (Wake Forest University)H-Index: 31
Last. Christopher Koh (NIH: National Institutes of Health)H-Index: 26
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ABSTRACT null null Background null Garcinia cambogia, either alone or with green tea, is commonly promoted for weight loss. Sporadic cases of liver failure from G. cambogia have been reported, but its role in liver injury is controversial. null null null Methods null Among 1418 patients enrolled in the Drug-Induced Liver Injury Network (DILIN) from 2004 to 2018, we identified 22 cases (adjudicated with high confidence) of liver injury from G. cambogia either alone (n=5) or in combination with gr...
#1Phil A. Hart (The Ohio State University Wexner Medical Center)H-Index: 29
#2David Bradley (The Ohio State University Wexner Medical Center)H-Index: 15
Last. Jose Serrano (NIH: National Institutes of Health)H-Index: 49
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Summary null null Diabetes represents a group of diseases involving persistent hyperglycaemia. Exocrine disorders of the pancreas are increasingly recognised to cause or precede the onset of diabetes, which in this context is referred to as pancreatogenic or type 3c diabetes. Diabetes, as a sequela of acute pancreatitis, is observed across the spectrum of severity in acute pancreatitis and can be associated with other clinical complications. The pathophysiology of acute pancreatitis-related diab...
#1Jay H. HoofnagleH-Index: 138
#2Herbert L. Bonkovsky (Wake Forest University)H-Index: 31
Last. Victor J. NavarroH-Index: 19
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BACKGROUND AND AIMS Herbal supplements, and particularly multi-ingredient products, have become increasingly common causes of acute liver injury. Green tea is a frequent component in implicated products, but its role in liver injury is controversial. The aim of this study was to better characterize the clinical features, outcomes, and pathogenesis of green tea-associated liver injury. APPROACH AND RESULTS Among 1,414 patients enrolled in the U.S. Drug-Induced Liver Injury Network who underwent f...
3 CitationsSource
#1Jose Serrano (NIH: National Institutes of Health)H-Index: 49
#2Jo Ann RinaudoH-Index: 14
Last. Dana K. AndersenH-Index: 21
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PURPOSE OF REVIEW Diseases of the pancreas are a broad spectrum of conditions resulting from metabolic, inflammatory, and neoplastic processes (pancreatitis, pancreatogenic diabetes, and pancreatic cancers). Pancreatic diseases cause significant morbidity, mortality, and cost. RECENT FINDINGS Research progress in diseases of the exocrine pancreas (chronic pancreatitis [CP], pancreatogenic diabetes mellitus, and pancreatic cancer) has been hampered by the disorders' heterogeneity, the limitations...
#1Zobeida Cruz-Monserrate (The Ohio State University Wexner Medical Center)H-Index: 21
#2Kristyn Gumpper (The Ohio State University Wexner Medical Center)H-Index: 9
Last. Darwin L. Conwell (The Ohio State University Wexner Medical Center)H-Index: 53
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Abstract Background Chronic pancreatitis (CP) does not have diagnostic or prognostic biomarkers. CP is the end stage of a progressive inflammatory syndrome that is diagnosed at late stages by morphologic features. To diagnose earlier stages of the disease, a new mechanistic definition was established based on identifying underlying pathogenic processes and biomarker evidence of disease activity and stage. Although multiple risk factors are known, the corresponding biomarkers needed to make a hig...
1 CitationsSource
#2Amy L. RoeH-Index: 16
Last. Richard KoH-Index: 7
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Abstract As part of the United States Pharmacopeia’s ongoing review of dietary supplement safety data, a new comprehensive systematic review on green tea extracts (GTE) has been completed. GTEs may contain hepatotoxic solvent residues, pesticide residues, pyrrolizidine alkaloids and elemental impurities, but no evidence of their involvement in GTE-induced liver injury was found during this review. GTE catechin profiles vary significantly with manufacturing processes. Animal and human data indica...
31 CitationsSource
#1Tonya M. Palermo (Seattle Children's Research Institute)H-Index: 66
#2Caitlin B. Murray (Seattle Children's Research Institute)H-Index: 13
Last. Aliye Uc (Boston Children's Hospital)H-Index: 27
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Abstract Introduction Abdominal pain is common and is associated with high disease burden and health care costs in pediatric acute recurrent and chronic pancreatitis (ARP/CP). Despite the strong central component of pain in ARP/CP and the efficacy of psychological therapies for other centralized pain syndromes, no studies have evaluated psychological pain interventions in children with ARP/CP. The current trial seeks to 1) evaluate the efficacy of a psychological pain intervention for pediatric ...
7 CitationsSource
#1Gregory A. CoteH-Index: 42
#2Valerie Durkalski-Mauldin (MUSC: Medical University of South Carolina)H-Index: 6
Last. Dhiraj Yadav (University of Pittsburgh)H-Index: 52
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OBJECTIVES: In patients with acute recurrent pancreatitis (ARP), pancreas divisum, and no other etiologic factors, endoscopic retrograde cholangiopancreatography (ERCP) with minor papilla endoscopic sphincterotomy (miES) is often performed to enlarge the minor papillary orifice, based on limited data. The aims of this study are to describe the rationale and methodology of a sham-controlled clinical trial designed to test the hypothesis that miES reduces the risk of acute pancreatitis. METHODS: T...
7 CitationsSource
#1Temel Tirkes (IU: Indiana University)H-Index: 15
#2Dhiraj Yadav (University of Pittsburgh)H-Index: 52
Last. Evan L. Fogel (IU: Indiana University)H-Index: 54
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Characteristic features of chronic pancreatitis (CP) may be absent on standard imaging studies. Quantitative Magnetic Resonance Imaging (MRI) techniques such as T1 mapping, extracellular volume (ECV) fraction, diffusion-weighted imaging (DWI) with apparent diffusion coefficient map (ADC), MR elastography (MRE), and T1-weighted signal intensity ratio (SIR) have shown promise for the diagnosis and grading severity of CP. However, radiologists still use the Cambridge classification which is based o...
20 CitationsSource
#1Herbert L. Bonkovsky (Wake Forest University)H-Index: 31
#2Tyler J Severson (Wake Forest University)H-Index: 2
Last. US Dilin InvestigatorsH-Index: 1
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: With the application of genetic testing to contemporary medical diagnostics and practice, it has become apparent that the phenotypes of many disorders are modulated by host genetic factors. The aim of the current study was to determine whether selected single nucleotide polymorphisms (SNPs) unrelated to the human leukocyte antigen region or other immune pathways, including those associated with nonalcoholic fatty liver disease (NAFLD), may influence development, severity, or outcomes of drug-i...
2 CitationsSource