Maryam Kavousi
Erasmus University Rotterdam
Genome-wide association studyEpidemiologyFramingham Risk ScoreInternal medicineEndocrinologyCardiologyProspective cohort studyCohort studyRotterdam StudyHazard ratioDiseaseIntima-media thicknessBody mass indexPopulationProportional hazards modelStrokeMedicineBlood pressureMeta-analysis
311Publications
65H-index
17.3kCitations
Publications 329
Newest
#1Peitao Wu (BU: Boston University)H-Index: 5
#2Jee-Young Moon (Albert Einstein College of Medicine)H-Index: 15
Last. Jordi MerinoH-Index: 19
view all 52 authors...
OBJECTIVE null LDL cholesterol (LDLc)-lowering drugs modestly increase body weight and type 2 diabetes risk, but the extent to which the diabetogenic effect of lowering LDLc is mediated through increased BMI is unknown. null RESEARCH DESIGN AND METHODS null We conducted summary-level univariable and multivariable Mendelian randomization (MR) analyses in 921,908 participants to investigate the effect of lowering LDLc on type 2 diabetes risk and the proportion of this effect mediated through BMI. ...
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#1Andy B Castaneda (University of Texas Health Science Center at Houston)
#2Lauren E. Petty (VUMC: Vanderbilt University Medical Center)H-Index: 11
Last. Paul S. de VriesH-Index: 26
view all 47 authors...
Carotid intima media thickness (cIMT) is a biomarker of subclinical atherosclerosis and a predictor of future cardiovascular events. Identifying associations between gene expression levels and cIMT may provide insight to atherosclerosis etiology. Here, we use two approaches to identify associations between mRNA levels and cIMT: differential gene expression analysis in whole blood and S-PrediXcan. We used microarrays to measure genome-wide whole blood mRNA levels of 5647 European individuals from...
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#1William J. Young (QMUL: Queen Mary University of London)H-Index: 4
#2Najim Lahrouchi (Broad Institute)H-Index: 11
Last. Patricia B. Munroe (QMUL: Queen Mary University of London)H-Index: 91
view all 166 authors...
The QT interval is an electrocardiographic measure representing the sum of ventricular depolarization (QRS duration) and repolarization (JT interval). Abnormalities of the QT interval are associated with potentially fatal ventricular arrhythmia. We conducted genome-wide multi-ancestry analyses in >250,000 individuals and identified 177, 156 and 121 independent loci for QT, JT and QRS, respectively, including a male-specific X-chromosome locus. Using gene-based rare-variant methods, we identified...
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#2Daniel Bos (Harvard University)H-Index: 26
Abstract null null Background and aims null The sex-specific contributions of arterial calcification to ASCVD risk prediction and stratification in the light of recent modifications by cardiovascular prevention guidelines remain unclear. We assessed the sex-specific value of calcification in different arteries, beyond the Pooled Cohort Equations (PCE) risk factors, for 10-year atherosclerotic cardiovascular disease (ASCVD) risk prediction. null null null Methods null From 2003 to 2006, participa...
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#1Kan Wang (EUR: Erasmus University Rotterdam)H-Index: 1
#2Fariba Ahmadizar (EUR: Erasmus University Rotterdam)H-Index: 15
Last. Maryam Kavousi (EUR: Erasmus University Rotterdam)H-Index: 65
view all 6 authors...
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#1Z Lu (EUR: Erasmus University Rotterdam)
#2M.J Tilly (EUR: Erasmus University Rotterdam)
Last. Maryam Kavousi (EUR: Erasmus University Rotterdam)H-Index: 65
view all 8 authors...
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#1M.J Tilly (EUR: Erasmus University Rotterdam)
#2Z Lu (EUR: Erasmus University Rotterdam)
Last. Maryam Kavousi (EUR: Erasmus University Rotterdam)H-Index: 65
view all 8 authors...
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#1M.J Tilly (EUR: Erasmus University Rotterdam)
#2S Geurts (EUR: Erasmus University Rotterdam)H-Index: 1
Last. Maryam Kavousi (EUR: Erasmus University Rotterdam)H-Index: 65
view all 7 authors...
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#1Negin Soroush (EUR: Erasmus University Rotterdam)H-Index: 1
Last. Bruno H. Stricker (EUR: Erasmus University Rotterdam)H-Index: 102
view all 8 authors...
Digoxin is characterized by a small therapeutic window and a QT-interval shortening effect. Moreover, it has been shown that the genetic variants of the nitric oxide synthase-1 adaptor protein (NOS1AP) gene are associated with QT-interval prolongation. We investigated whether the rs10494366 variant of the NOS1AP gene decreases the QT-interval shortening effect of digoxin in patients using this drug. We included 10,057 individuals from the prospective population-based cohort of the Rotterdam Stud...
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