Kenkichi Shinkai
HMG-CoA reductasePenicillinChemistrySplenocyteImmunologyAllergyStreptomycinAmpicillinSimvastatinBenzylpenicillinSubcutaneous injectionHumoral immunityAdjuvantCefazolinGuinea pigAntigenicityArthus reactionPravastatinCarbenicillinImmunopathologyBALB/c MouseCellular immunityDelayed hypersensitivityPlaque forming cellIgm antibodyAntibacterial agentAntibioticsStrain (chemistry)Inbred strainBiologyImmune systemMicrobiologyPharmacology
8Publications
4H-index
39Citations
Publications 8
Newest
#1Kenkichi ShinkaiH-Index: 4
#1Kanade ShinkaiH-Index: 26
Last. Eiji MakiH-Index: 5
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In the present collaborative study, popliteal lymph node (PLN) responses to penicillin G (an allergenic chemical), D-penicillamine (an autoimmunity-inducing chemical), and barbital (a negative reference chemical) were investigated in three different mouse strains by ten pharmaceutical companies. Two inbred mouse strains (BALB/c and A/J) and one outbred strain (ICR) were subcutaneously injected with saline solutions containing penicillin G (1.25, 2.5 and 5 mg/mouse), D-penicillamine (0.5, 1 and 2...
9 CitationsSource
#1Tetsuo AidaH-Index: 6
#2Tsutomu KimuraH-Index: 2
Last. Kenkichi ShinkaiH-Index: 4
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In the present study, the correlation between mouse PLNA and those obtained from GP-PCA and from GP-ASA reactions fro sodium 2, 4, 6-trinitrobenzenesulfonate dihydrate (TNBS), penicillin G and cephalothin was investigated. Next, variou drugs were tested using the mouse PLNA to study whether PLN reactivity could be related to the potential of the compounds to induce allergic and autoimmune disorders in humans. The parameter of the PLNA was determined by the PLN cellularity index in BALB/c and A/J...
13 CitationsSource
#1Naohisa TsutsuiH-Index: 4
#1N. TsutsuiH-Index: 2
Last. E. MakiH-Index: 2
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2 Citations
#1Kanade ShinkaiH-Index: 26
#1Kenkichi ShinkaiH-Index: 4
Last. Eiji MakiH-Index: 5
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1 Citations
Guinea pigs of two strains, outbred Hartley and inbred Strain 2, were immunized sub-cutaneously with cephalothin (CET, 20 mg/body) alone, without adjuvant. Immune responses to the antibiotic were assessed by guinea-pig passive cutaneous anaphylaxis (GP-PCA) and active systemic anaphylaxis (GP-ASA) reactions. The immune response to CET in the female Hartley guinea pigs was higher than that in the males. In contrast, no difference in response to CET in Strain 2 guinea pigs was observed between mal...
4 CitationsSource
The present experiments were undertaken to clarify the differences in humoral immune response to two β-lactam antibiotics, benzylpenicillin potassium (PcG) and cephalothin sodium (CET), in guinea-pig strains. Guinea pigs of three different strains, Hartley, Strain 2 and Strain 13, were immunized subcutaneously with PcG (10mg/body) 1 or 3 times a week, 10 times in total, or with CET (20 mg/body) 3 times a week, 12 times in total. Humoral immune responses to the two antibiotics were assessed by pa...
3 CitationsSource
: The present experiments were undertaken to clarify the differences in humoral and cellular immune responses to a low-molecular compound, sodium 2,4,6-trinitrobenznnesul fonate dihydrate (TNBS) in guinea-pig strains. Guinea pigs of three different strains, Hartley, Strain 2 and Strain 13, were immunized subcutaneously with TNBS (3 mg/body) 2 or 3 times a week, 9 times in total. Humoral immune responses to TNBS were assessed by passive cutaneous anaphylaxis (PCA) and Arthus reaction, and cellula...
5 CitationsSource
#1Tsutomu KimuraH-Index: 1
#2Kenkichi ShinkaiH-Index: 4
Last. Kikuo NomotoH-Index: 62
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Effects of pravastatin and simvastatin on the humoral immune response were studied using Cunningham's method of the IgM plaque-forming cell (PFC) assay system in mice. The vehicle (0.5% CMC), pravastatin (1 mg/body : about 50 mg/kg) or simvastatin (0.5 mg/body : about 25 mg/kg) were given orally for 14 days in experiment (Exp)-I and Exp-II. The vehicle, pravastatin (0.5 mg/body : about 25 mg/kg) or simvastatin (0.25 mg/body : about 12.5 mg/kg) were given orally 29 times for 32 days in Exp-III. T...
2 CitationsSource