Shadi Yaqoubi
Tabriz University of Medical Sciences
ParticleHausner ratioBiomedical engineeringDeposition (phase transition)NanotechnologyVolumetric flow rateChemistryParticle sizeMaterials scienceInhalationDry-powder inhalerSpray dryingDrug deliveryInhalerSolventDifferential scanning calorimetryChemical engineeringChromatographyActive ingredientAerosolizationPharmacology
14Publications
5H-index
41Citations
Publications 15
Newest
#1Ali Akbar Alizadeh (Tabriz University of Medical Sciences)H-Index: 8
#2Michael B. Morris (USYD: University of Sydney)H-Index: 21
Last. Siavoush Dastmalchi (NEU: Near East University)H-Index: 25
view all 5 authors...
TNFα participates in a variety of physiological processes, but at supra-physiological concentrations it has been implicated in the pathology of inflammatory and autoimmune diseases. Therefore, much attention has been devoted to the development of strategies that overcome the effects of aberrant TNFα concentration. Promising strategies include drugs that destabilize the active (trimeric) form of TNFα and antagonists of TNFα receptor type I. Underpinning these strategies is the successful applicat...
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#1Shadi Yaqoubi (Tabriz University of Medical Sciences)H-Index: 5
#2Hak-Kim Chan (USYD: University of Sydney)H-Index: 76
Last. Hamed Hamishehkar (Tabriz University of Medical Sciences)H-Index: 44
view all 8 authors...
Abstract Dry powder inhalers (DPI) are widely used systems for pulmonary delivery of therapeutics. The inhalation performance of DPIs is influenced by formulation features, inhaler device and inhalation pattern. The current review presents the affecting factors with great focus on powder characteristics which include particle size, shape, surface, density, hygroscopicity and crystallinity. The properties of a formulation are greatly influenced by a number of physicochemical factors of drug and a...
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#1Elahehnaz Parhizkar (Shiraz University of Medical Sciences)H-Index: 6
#2Delaram Sadeghinia (Shiraz University of Medical Sciences)
Last. Shohreh AlipourH-Index: 10
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Purpose: Pulmonary Tuberculosis (TB) is a worldwide life-threatening infection. The recommended anti-TB regimen contains oral administration of classical first-line drugs such as rifampin for 6-24 months which often leads to low patient compliance due to high adverse effects; therefore, lung localized pulmonary delivery of anti-TB agents may be a suitable alternative. Proliposomes free-flowing powders are well-known carriers for lung delivery since they can form liposomes by hydration. Liposomes...
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#1Shadi Yaqoubi (Tabriz University of Medical Sciences)H-Index: 5
#2Khosro Adibkia (Tabriz University of Medical Sciences)H-Index: 31
Last. Mohammad Barzegar-Jalali (Tabriz University of Medical Sciences)H-Index: 35
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Abstract In the current study electrospraying methodology was used for particle engineering of montelukast and budesonide to prepare a combined inhalable dry powder formulation applicable as a smart regimen in asthma treatment. For this, electrospraying was carried out using different solvents and drug concentrations. No carrier was added for the formulation of montelukast-budesonide combination as montelukast played the role of both active ingredient and carrier. Scanning electron microscopy, p...
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#1Kaveh Ahookhosh (University of Tabriz)H-Index: 4
#2Maysam Saidi (Razi University)H-Index: 10
Last. Shadi Yaqoubi (Tabriz University of Medical Sciences)H-Index: 5
view all 6 authors...
Abstract Effective drug delivery into the lungs plays an important role in management of pulmonary diseases that affect millions all around the world. The main objective of this investigation is to study airflow structure, as well as transport and deposition of micron-size particles at different inhalation flow rates in a realistic model of human tracheobronchial airways. The airway model was developed based on computed tomography (CT) images of a healthy 48-years-old female, which includes extr...
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#1Fariba Azari (Tabriz University of Medical Sciences)H-Index: 1
#2Saeed Ghanbarzadeh (Zanjan University of Medical Sciences)H-Index: 20
Last. Hamed Hamishehkar (Tabriz University of Medical Sciences)H-Index: 44
view all 6 authors...
Background Pulmonary drug delivery route is gaining much attention because it enables to target the active ingredients directly to lung both for local and systemic treatments, which maximize the therapeutic effect and minimize unwanted systemic toxicity. Dry powder inhaler (DPI) systems for asthma therapy have shown several merits to the other pulmonary delivery systems such as nebulizers and metered dose inhalers. Purpose The present study aims to develop and optimize a DPI formulation for Keto...
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#9Ali Mohammadi (University of Southern Denmark)H-Index: 11
Purpose: This study was aimed to evaluate the site-specific drug delivery of 5-FU with chitosan (CS) as a carrier and quercetin (Qu) against induced colon cancer in Wistar rats. Methods : Cross-linked CS-Qu nanoparticles (NPs) were prepared by ionotropic gelation method. Physicochemical characterization of NPs was performed by Fourier-transform infrared (FTIR) spectroscopy, dynamic light scattering (DLS), in vitro drug release, and drug loading efficiency (LE). 1, 2-Dimethylhydrazine (DMH) and d...
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#1Kaveh Ahookhosh (University of Tabriz)H-Index: 4
#2Shadi Yaqoubi (Tabriz University of Medical Sciences)H-Index: 5
Last. Habib Aminfar (University of Tabriz)H-Index: 16
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Abstract Purpose In the present work, a comparison between MDI and DPI for evaluating performance of the devices were carried out by experimentally investigating the deposition parameters through a realistic airway replica. Methods Computed tomography (CT) images of the respiratory airway of a healthy subject were used to develop the realistic model. The airway replica was included extrathoracic, trachea, and tracheobronchial tree up to fourth generations which was fabricated by rapid prototypin...
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#1Sepideh MardaniH-Index: 1
#2Maryam MaghsoodiH-Index: 12
Last. Hamed HamishehkarH-Index: 44
view all 6 authors...
Background: Celecoxib is a non-steroidal anti-inflammatory drug used extensively in the treatment of pain, arthritis, and cancers. However, its administration is limited due to its several disadvantages including gastric irritation and hepatic first pass metabolism. Among numerous methods for pulmonary drug delivery, dry powder inhalation systems show the promising approach to be used as alternative routes for oral drug delivery. This study was conducted to develop agglomerated nanocrystals and ...
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#1Saeed Ghanbarzadeh (Zanjan University of Medical Sciences)H-Index: 20
#2Hadi Valizadeh (Tabriz University of Medical Sciences)H-Index: 39
Last. Hamed Hamishehkar (Tabriz University of Medical Sciences)H-Index: 44
view all 5 authors...
Background Tablets and capsules are the most accepted and widely used solid dosage forms in the medical therapy. Flow property of the powders is playing a key role in the various pharmaceutical fields especially in the fomulation of tablets and capsules. The high hygroscopic crystalline structure of anhydrous Divalproex sodium (DVX) makes it to be appear as waxy white flakes with almost no powder flowability which cause serious problems during the tabletting and capsule filling procedures. Purpos...
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