Inbal Egoz
Israel Institute for Biological Research
Q-switchingOpticsPathologyChemistryAtropineOrganophosphateCorneaRetinaMiosisNd:YAG laserMidazolamNerve agentHomatropineSarinTropicamideRetinalOptic nervePupillary light reflexBrain damageToxicityCholinesteraseAnesthesiaLaserMedicinePharmacology
28Publications
7H-index
173Citations
Publications 28
Newest
#1Vered Horwitz (Israel Institute for Biological Research)H-Index: 10
#2Inbal Egoz (Israel Institute for Biological Research)H-Index: 7
Last. Ariel Gore (Israel Institute for Biological Research)H-Index: 6
view all 8 authors...
#1Merav Blanca (Israel Institute for Biological Research)H-Index: 3
#2Avital Shifrovitch (Israel Institute for Biological Research)H-Index: 2
Last. Avi Weissberg (Israel Institute for Biological Research)H-Index: 7
view all 13 authors...
Long-term retrospective monitoring of exposure to organophosphorus nerve agents is challenging. We recently developed two highly sensitive analytical methods for regenerated sarin (GB) nerve agent in blood and its primary metabolite, isopropyl-methylphosphonic acid (IMPA), in urine. These methods were implemented in a toxicokinetics study carried out with sarin injected (i.v.) to rabbits at doses corresponding to 0.1, 0.5 or 0.9 LD50. The time frame for monitoring regenerated sarin from blood wa...
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#1Ariel GoreH-Index: 6
#2Adi Neufeld-CohenH-Index: 1
Last. Shlomi LazarH-Index: 11
view all 12 authors...
Abstract The development of refractory status epilepticus (SE) induced by sarin intoxication presents a therapeutic challenge. In our current research we evaluate the efficacy of a delayed combined triple treatment in ending the abnormal epileptiform seizure activity (ESA) and the ensuing of long-term neuronal insult. SE was induced in male Sprague-Dawley rats by exposure to 1.2LD50 sarin insufficiently treated by atropine and TMB4 (TA) 1 min later. Triple treatment of ketamine, midazolam and va...
1 CitationsSource
#1Ariel Gore (Israel Institute for Biological Research)H-Index: 6
#2Adi Neufeld-Cohen (Israel Institute for Biological Research)H-Index: 1
Last. Shlomi Lazar (Israel Institute for Biological Research)H-Index: 11
view all 8 authors...
Abstract Background Sarin is an irreversible organophosphate cholinesterase inhibitor. Following toxic signs, an extensive long-term brain damage is often reported. Thus, we evaluated the efficacy of a novel anticonvulsant drug retigabine, a modulator of neuronal voltage gated K+ channels, as a neuroprotective agent following sarin exposure. Methods Rats were exposed to 1 LD50 or 1.2 LD50 sarin and treated at onset of convulsions with retigabine (5 mg/kg, i.p.) alone or in combination with 5 mg/...
6 CitationsSource
#1Merav Blanca (Israel Institute for Biological Research)H-Index: 3
#2Avital Shifrovitch (Israel Institute for Biological Research)H-Index: 2
Last. Avi Weissberg (Israel Institute for Biological Research)H-Index: 7
view all 12 authors...
The highly toxic nerve agent sarin (o-isopropyl methyl-phosphonofluoridate, GB) has been used in several armed conflicts and terror attacks in recent decades. Due to its inherent high sensitivity, liquid chromatography–mass spectrometry (LC–MS/MS) has the potential to detect ultratrace levels of fluoride-regenerated G and V agents after appropriate chemical derivatization. A new method for the retrospective determination of exposure to sarin was developed. The method is based on sarin regenerati...
5 CitationsSource
#1Ariel Gore (Israel Institute for Biological Research)H-Index: 6
#2Shlomi Lazar (Israel Institute for Biological Research)H-Index: 11
Last. Tamar Kadar (Israel Institute for Biological Research)H-Index: 26
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Abstract Eye exposure to organophosphate (OP) chemical warfare irreversible acetylcholinesterase inhibitors, results in long-term miosis and impaired visual function. In contrast to the well-documented miotic and ciliary muscle spasm observed following chemical warfare, OP ocular exposure, little is known regarding the ocular surface histopathological insult. The aim of the present study was to determine the degree of the ocular surface insult following sarin or VX ocular exposure and to evaluat...
3 CitationsSource
#1Vered Horwitz (Israel Institute for Biological Research)H-Index: 10
#2Inbar Cohen-Gihon (Israel Institute for Biological Research)H-Index: 5
Last. Ofir Israeli (Israel Institute for Biological Research)H-Index: 10
view all 14 authors...
Abstract Exposure to sulfur mustard (SM) may result in severe ocular injuries. While some of the eyes show a clinical resolution of the injury (defined as clinically non-impaired), part of the eyes develop irreversible late ocular pathologies (defined as clinically impaired) that may lead to corneal blindness. Understanding the pathological mechanisms underlying the development of the late pathology may lead to improved treatment options. Therefore, this study aimed to investigate the mRNA expre...
4 CitationsSource
#1Shira Chapman (Israel Institute for Biological Research)H-Index: 16
#2Ettie Grauer (Israel Institute for Biological Research)H-Index: 15
Last. Shlomi Lazar (Israel Institute for Biological Research)H-Index: 11
view all 5 authors...
Abstract A common consequence of exposure to organophosphate nerve agents is the centrally mediated seizure activity that appears even after conventional treatment with atropine and oximes. We have previously demonstrated a major inflammatory response with subsequent brain damage which was correlated with the duration of the sarin-induced seizures (Chapman et al., 2006). In the present work seizures were induced by the nerve agent sarin (1.2 LD50) insufficiently treated 1 min later by atropine a...
2 CitationsSource
#1Eugenia Bloch-Shilderman (Israel Institute for Biological Research)H-Index: 6
#2Guy Yacov (Israel Institute for Biological Research)H-Index: 4
Last. Uri Nili (Israel Institute for Biological Research)H-Index: 4
view all 8 authors...
Exposure to the chemical warfare nerve agent VX is extremely toxic, causing severe cholinergic symptoms. If not appropriately treated, death ultimately ensues. Based on our previously described whole-body vapor exposure system, we characterized in detail the clinical outcome, including respiratory dynamics, typical of whole-body exposure to lethal doses of VX vapor in freely moving rats. We further evaluated the efficacy of two different antidotal regimens, one comprising a single and the other ...
3 CitationsSource
#1Eugenia Bloch-Shilderman (Israel Institute for Biological Research)H-Index: 6
#2Ishai Rabinovitz (Israel Institute for Biological Research)H-Index: 14
Last. Uri Nili (Israel Institute for Biological Research)H-Index: 4
view all 6 authors...
VX, a potent inhibitor of cholinesterase (ChE), is considered as one of the most toxic, persistent and least volatile nerve agents. VX is absorbed in various environmental surfaces and is gradually released long after its initial dispersal. Its toxicity is mainly caused by disrupting central and peripheral cholinergic nervous system activity, leading to potential long-term detrimental effects on health. The primary objective of the present study was to assess the threshold VX dose leading to min...
6 CitationsSource