Michael J. Paldino
Boston Children's Hospital
Correction for attenuationRadiologyPET-CTMagnetic resonance imagingDiffusion MRIMutual informationArtificial intelligencePsychologyNeurosciencePattern recognitionClustering coefficientPositron emission tomographyEpilepsyArcuate fasciculusWhite matterNuclear medicineComputer scienceMedicineCohortTractography
27Publications
12H-index
328Citations
Publications 26
Newest
#1Stephen F. Kralik (Boston Children's Hospital)H-Index: 12
#2M.K. Kukreja (Boston Children's Hospital)H-Index: 2
Last. Jesus G. Vallejo (BCM: Baylor College of Medicine)H-Index: 29
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BACKGROUND AND PURPOSE: Group B Streptococcus and Escherichia coli (E coli) are the 2 most common causes of bacterial meningitis in neonates. The purpose of this study was to determine whether CSF and/or MR imaging findings differ between infants with group B streptococcal or E coli meningitis. MATERIALS AND METHODS: A retrospective review was performed among neonates (younger than 28 days) and infants (younger than 120 days) with proved group B streptococcal (n = 57) or E coli meningitis (n = 5...
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#1Michael J. Paldino (Boston Children's Hospital)H-Index: 12
#2Farahnaz Golriz (Boston Children's Hospital)H-Index: 7
Last. Zili D. Chu (Boston Children's Hospital)H-Index: 3
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BACKGROUND AND PURPOSE: Architecture of the cerebral network has been shown to associate with IQ in children with epilepsy. However, subject-level prediction on this basis, a crucial step toward harnessing network analyses for the benefit of children with epilepsy, has yet to be achieved. We compared two network normalization strategies in terms of their ability to optimize subject-level inferences on the relationship between brain network architecture and brain function. MATERIALS AND METHODS: ...
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#1Robert Azencott (UH: University of Houston)H-Index: 20
#2Viktoria Muravina (UH: University of Houston)H-Index: 2
Last. Michael J. Paldino (Boston Children's Hospital)H-Index: 12
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To study large sets of interacting time series, we combine spectral analysis of graph Laplacians with simulated annealing to automatically generate optimized clustering of time series, by minimization of cost functions characterizing clustering quality. We apply these techniques to evaluation of connectivity between cortex regions, via analysis of cortex activity recordings by sequences of 3-dimensional fMRI images.
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#3Wei Zhang (Boston Children's Hospital)H-Index: 16
By computerized analysis of cortical activity recorded via fMRI for pediatric epilepsy patients, we implement algorithmic localization of epileptic seizure focus within one of eight cortical lobes. Our innovative machine learning techniques involve intensive analysis of large matrices of mutual information coefficients between pairs of anatomically identified cortical regions. Drastic selection of pairs of regions with significant inter-connectivity provide efficient inputs for our Multi-Layer P...
#1A. Hsu (Boston Children's Hospital)H-Index: 1
#2Nilesh K. Desai (Boston Children's Hospital)H-Index: 9
Last. Michael J. Paldino (Boston Children's Hospital)H-Index: 12
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BACKGROUND AND PURPOSE: Branchio-oto-renal syndrome is an important syndromic cause of hearing loss. Our aim was to determine the test characteristics of the unwound cochlea on temporal bone CT for the diagnosis of branchio-oto-renal syndrome in a cohort of children with hearing loss. MATERIALS AND METHODS: Patients were identified retrospectively with a clinical diagnosis of branchio-oto-renal syndrome and CT imaging of the temporal bones. Age-matched controls were also identified with sensorin...
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#1Nisha Gadgil (BCM: Baylor College of Medicine)H-Index: 7
#2Sandi Lam (BCM: Baylor College of Medicine)H-Index: 30
Last. Robert C. Dauser (BCM: Baylor College of Medicine)H-Index: 31
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OBJECTIVENumerous surgical procedures facilitate revascularization of the ischemic brain in patients with moyamoya disease. Dural inversion is a technique in which flaps of dura mater centered around the middle meningeal artery are inverted, encouraging the formation of a rich collateral blood supply. This procedure has been used in combination with encephaloduroarteriosynangiosis for more than 20 years at the authors’ institution for the treatment of pediatric moyamoya disease. The objective of...
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#1Wei Zhang (Boston Children's Hospital)H-Index: 16
#2Viktoria Muravina (UH: University of Houston)H-Index: 2
Last. Michael J. Paldino (Boston Children's Hospital)H-Index: 12
view all 5 authors...
Purpose. Metrics of the brain network architecture derived from resting-state fMRI have been shown to provide physiologically meaningful markers of IQ in children with epilepsy. However, traditional measures of functional connectivity (FC), specifically the Pearson correlation, assume a dominant linear relationship between BOLD time courses; this assumption may not be valid. Mutual information is an alternative measure of FC which has shown promise in the study of complex networks due to its abi...
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#5Wei Zhang (Boston Children's Hospital)H-Index: 85
BACKGROUND AND PURPOSE: Congenital aqueductal stenosis is a common cause of prenatal ventriculomegaly. An accurate diagnosis provides prognostic information and may guide obstetric management. The purpose of this study was to identify specific anatomic findings on prenatal MR imaging that can be used as predictors of congenital aqueductal stenosis. MATERIALS AND METHODS: Prenatal and postnatal MRIs of fetuses referred to our institution for ventriculomegaly between June 2008 and August 2015 were...
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#1Michael J. Paldino (Boston Children's Hospital)H-Index: 12
#2Zili D. Chu (Boston Children's Hospital)H-Index: 3
Last. Wei Zhang (Boston Children's Hospital)H-Index: 16
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Objective:To measure the repeatability of metrics that quantify brain network architecture derived from resting-state functional MRI in a cohort of paediatric patients with epilepsy.Methods:We identified patients with: (1) epilepsy; (2) brain MRI at 3 T; (3) two identical resting-state functional MRI acquisitions performed on the same day. Undirected, weighted networks were constructed based on the resting-state time series using a range of processing parameters including parcellation size and g...
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#1Michael J. Paldino (Boston Children's Hospital)H-Index: 12
#2Erica YangH-Index: 1
Last. Victor Seghers (Boston Children's Hospital)H-Index: 9
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Background There is great interest in positron emission tomography (PET)/magnetic resonance (MR) as a clinical tool due to its capacity to provide diverse diagnostic information in a single exam.
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