Arihiko Kanehiro
Okayama University
AirwayInternal medicineChemokineEndocrinologyPathologyReceptorImmunologyAllergyAsthmaInflammationOvalbuminEosinophilEosinophiliaLungBronchoalveolar lavageCytokineAllergic inflammationElastaseMethacholineMedicineBiologyGastroenterology
103Publications
25H-index
1,997Citations
Publications 104
Newest
#1Satoru Senoo (Okayama University)H-Index: 5
#2Akihiko Taniguchi (Okayama University)H-Index: 10
Last. Fumiaki TokiokaH-Index: 1
view all 14 authors...
Acute exacerbation of idiopathic pulmonary fibrosis has a poor prognosis associated with neutrophilic inflammation. Interleukin-23 is a proinflammatory cytokine involved in neutrophilic inflammation. However, little is known about its role in acute exacerbation of pulmonary fibrosis. This study was performed to determine the role of interleukin-23 in acute exacerbation of pulmonary fibrosis. For assessment of acute exacerbation of pulmonary fibrosis, mice were intratracheally administered bleomy...
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#1Daisuke Morichika (Okayama University)H-Index: 8
#2Akihiko Taniguchi (Okayama University)H-Index: 10
Last. Masayuki Hanaoka (Shinshu University)H-Index: 28
view all 15 authors...
Background IL-33, which is known to induce type 2 immune responses via group 2 innate lymphoid cells, has been reported to contribute to neutrophilic airway inflammation in chronic obstructive pulmonary disease. However, its role in the pathogenesis of emphysema remains unclear. Methods We determined the role of interleukin (IL)-33 in the development of emphysema using porcine pancreas elastase (PPE) and cigarette smoke extract (CSE) in mice. First, IL-33-/- mice and wild-type (WT) mice were giv...
1 CitationsSource
#1Satoru Senoo (Okayama University)H-Index: 5
#2Nobuaki Miyahara (RMIT: RMIT University)H-Index: 33
Last. Katsuyuki Kiura (Okayama University)H-Index: 68
view all 20 authors...
BACKGROUND Nintedanib is a multi-kinase inhibitor approved for idiopathic pulmonary fibrosis (IPF); however, its efficacy and safety for patients with IPF and restricted pulmonary function remain unclear. Therefore, the objective of this study was to determine the efficacy and safety of nintedanib for patients with IPF and forced vital capacity (FVC) ≤ 50%. METHODS This was a multi-center retrospective study performed by the Okayama Respiratory Disease Study Group. Patients were allocated into F...
2 CitationsSource
#1Hisao Higo (Okayama University)H-Index: 6
#2Nobuaki Miyahara (RMIT: RMIT University)H-Index: 33
Last. Katsuyuki Kiura (Okayama University)H-Index: 68
view all 15 authors...
Abstract Background Pirfenidone suppresses the decline of forced vital capacity (FVC) in patients with idiopathic pulmonary fibrosis (IPF). However, IPF progresses in some patients despite treatment. We analyzed patients with meaningful FVC declines during pirfenidone treatment and explored the factors predictive of disease progression after FVC decline. Methods This study was a retrospective, multicenter, observational study conducted by the Okayama Respiratory Disease Study Group. We defined i...
1 CitationsSource
#1Naohiro Oda (Okayama University)H-Index: 8
#2X. Nobuaki Miyahara (RMIT: RMIT University)H-Index: 1
Last. Yoshinobu Maeda (Okayama University)H-Index: 29
view all 11 authors...
Neuropeptide Y (NPY) is a neurotransmitter that is widely expressed in the brain and peripheral nervous system. Various immune cells express the NPY Y1 receptor. NPY modulates these cells via its Y...
8 CitationsSource
#8K. Kiura (Okayama University)
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#1Daisuke Morichika (Okayama University)H-Index: 8
#2Nobuaki Miyahara (Okayama University)H-Index: 33
Last. Arihiko Kanehiro (Okayama University)H-Index: 25
view all 12 authors...
Retinoid X receptors (RXRs) are members of the nuclear receptor (NR) superfamily that mediate signalling by 9-cis retinoic acid, a vitamin A derivative. RXRs play key roles not only as homodimers but also as heterodimeric partners, e.g., for retinoic acid receptors, vitamin D receptors, and peroxisome proliferator-activated receptors. The NR family may also play important roles in the development of emphysema. However, the role of RXRs in the pathogenesis of emphysema is not well defined. We dev...
12 CitationsSource
#1Naohiro Oda (Okayama University)H-Index: 8
#2Nobuaki Miyahara (RMIT: RMIT University)H-Index: 33
Last. Arihiko Kanehiro (Okayama University)H-Index: 25
view all 10 authors...
12 CitationsSource
Source
#1Akihiko TaniguchiH-Index: 10
#2Nobuaki Miyahara (RMIT: RMIT University)H-Index: 33
Last. Katsuyuki KiuraH-Index: 68
view all 12 authors...
Although recent retrospective studies suggested that the use of β-blockers appears to help improve the mortality rate and decrease the rate of exacerbation in chronic obstructive pulmonary disease (COPD) patients with heart failure, the effects of β-blockers on COPD patients without heart failure have not been established. Based on previous reports, we have launched a multicenter, prospective, single-arm phase II study to evaluate the preventive effect of the cardioselective β-blocker bisoprolol...
3 CitationsSource