Xiaorong Zhou
Nantong University
GeneEnhancerInternal medicineDownregulation and upregulationInterleukin 21EndocrinologyCytotoxic T cellGene knockdownChemistryInterleukin 4ImmunologyIn vivoT cellInflammationVascular endothelial growth factorArthritisRheumatoid arthritisPancreatic tumorDendritic cellPancreatic cancerTriptolideEpigeneticsCancer researchCarcinogenesisCell growthMedicineCell cultureBiologyImmune systemCell biology
14Publications
4H-index
66Citations
Publications 14
Newest
#1Xiaoling Ding (Nantong University)H-Index: 3
#2Jie Zhang (Nantong University)H-Index: 7
Last. Xiaorong Zhou (Nantong University)H-Index: 2
view all 5 authors...
In colorectal cancer (CRC), miR-137-3p downregulation is associated with disease progression, but the mechanism is not fully understood. KDM1A, also known as LSD1, is upregulated in various cancer and promotes tumor metastasis. Interestingly, miR-137-3p is downregulated by hypoxia, which plays critical roles in tumor metastasis, and KDM1A is a miR-137-3p target gene in brain tumors. To study if CRC metastasis is regulated by a hypoxia/miR-137-3p/KDM1A axis and if the epithelial–mesenchymal trans...
4 CitationsSource
#1Yu Zhao (Nantong University)H-Index: 10
#2Yuejiao Cao (Nantong University)H-Index: 1
Last. Xiaorong Zhou (Nantong University)H-Index: 4
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Loss of the B2M gene is associated with tumor immune escape and resistance to immunotherapy. However, genetic alterations of the B2M gene are rare. We performed an integrative analysis of the mutational and transcriptional profiles of large cohorts of non-small-cell lung cancer (NSCLC) patients and found that epigenetic downregulation of B2M is common. B2M-low tumors exhibit a suppressive immune microenvironment characterized by reduced infiltration of immune cells of various lineages; in B2M-hi...
Source
#1Xiaoling Ding (Nantong University)H-Index: 3
#2Xiao-Ying Wang (Nantong University)H-Index: 5
Last. Xiaorong Zhou (Nantong University)H-Index: 2
view all 7 authors...
In Burkitt lymphoma (BL), a chromosomal translocation by which the MYC gene is fused to an immunoglobulin (Ig) gene locus is frequently found. The translocated MYC gene is overexpressed, which is the major driver of BL tumorigenesis. Studies have shown that Ig enhancers are essential for MYC overexpression, but the involved mechanisms are not fully understood. In addition, the survival of BL cells relies on B-cell receptor (BCR) signaling, which is determined by the levels of Ig molecules expres...
6 CitationsSource
#1Xiaorong Zhou (Nantong University)H-Index: 2
#1Xiaorong Zhou (Nantong University)H-Index: 4
Last. Xiao-Ying Wang (Nantong University)H-Index: 5
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: The rearrangement and expression of immunoglobulin genes are regulated by enhancers and their binding transcriptional factors that activate or suppress the activities of the enhancers. The immunoglobulin κ (Igκ) gene locus has three important enhancers: the intrinsic enhancer (Ei), 3' enhancer (E3'), and distal enhancer (Ed). Ei and E3' are both required for Igκ gene rearrangement during early stages of B-cell development, whereas optimal expression of the rearranged Igκ gene relies on both E3...
4 CitationsSource
#1Xiao-Ling Ding (Nantong University)H-Index: 8
#2Xiaorong Zhou (Nantong University)H-Index: 4
Last. Guo-Xiong Zhou (Nantong University)H-Index: 8
view all 5 authors...
: Triptolide (TL) is known to suppress the proliferation of a number of pancreatic cancer cell lines in vitro. Marked antitumor effects were also observed in a xenograft model of pancreatic cancer. Hypoxia‑inducible factor‑1α (HIF‑1α) is highly expressed in pancreatic cancer cells lines. The present study therefore tested the hypothesis that suppression of HIF‑1α is associated with the antitumor activity of TL. Quantitative polymerase chain reaction and western blot analysis were used to determi...
22 CitationsSource
Abstract Pancreatic cancer is characterized as a type of gastrointestinal tumor with a poor prognosis and high degree of malignancy. CIITA gene was found highly methylated in pancreatic carcinoma cell line PANC-1 and responsible for the low expression of MHC-II that may lead to immune evasion. Here, we tried to prepare pancreatic cancer vaccine with PANC-1 cells via epigenetic modification to enhance the MHC-II expression. Then the vaccine was injected into C57BL/6J mice and the effect was exami...
#1Dan-ping Pu (Nantong University)
#2Xiao-Ying Wang (Nantong University)H-Index: 5
Last. Xiaorong Zhou (Nantong University)H-Index: 4
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Objective To examine the therapeutic effect of C Ⅱ TA inhibition in collagen-induced arthritis(CIA),using a delivery system tailored to target C ⅡTA gene by small interfering RNA (siRNA).Methods Mice with collagen-induced arthritis were injected intravenously with C Ⅱ TA siRNA.The clinical score was monitored for up to 4 weeks after treatment.The severity of inflammation of mouse joint was evaluated by histological examination.Real-time PCR was used to determine the cytokine mRNA expression.Cyto...
Source
#1Xiao-Ling Ding (Nantong University)H-Index: 8
#2Xiaorong Zhou (Nantong University)H-Index: 4
Last. Guo-Xiong Zhou (Nantong University)H-Index: 8
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Purpose Pancreatic cancer has one of the highest fatality rates of all cancers, and new strategies or reagents to tackle this disease are needed. Triptolide (TL) is able to potently inhibit the growth of pancreatic tumor cells in vitro. On the other hand, blockage of 5-LOX pathway might be useful for treatment of pancreatic cancer. In the current study, we tested the effects of 5-LOX RNA interference and TL individually or in combination in suppressing human pancreatic tumor growth in xenograft ...
4 CitationsSource
#1Xiao-Ling Ding (Nantong University)H-Index: 8
#2Chen Zhu (Nantong University)H-Index: 1
Last. Guo-Xiong Zhou (Nantong University)H-Index: 8
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Abstract Cyclooxygenase (COX)-2 and lipoxygenase (LOX)-5 are involved in carcinogenesis of pancreatic cancer. COX-2 inhibitor celecoxib displays inhibitory effects in pancreatic cancer cell growth. Recently, it has been reported that COX-2 inhibitor may not be able to suppress pancreatic tumor growth in vivo and its application is further limited by untoward side effects. The present study provides evidence that combined use of celecoxib and 5-LOX inhibitor MK886 markedly suppresses pancreatic t...
18 CitationsSource
#2Chen ZhuH-Index: 1
Last. Guo-Xiong ZhouH-Index: 8
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