Yu Li
Anhui Agricultural University
Messenger RNAInternal medicineDownregulation and upregulationEndocrinologyAntigenMolecular biologyProinflammatory cytokineTumor necrosis factor alphaKinaseChemistryBasal (phylogenetics)ApoptosisInflammationIleumNF-?Bp38 mitogen-activated protein kinasesMAPK/ERK pathwaySignal transductionBiologyCell biologyPharmacology
40Publications
18H-index
315Citations
Publications 59
Newest
#1Hongyan Ding (AAU: Anhui Agricultural University)H-Index: 10
Sirtuin 1 (SIRT1), an NAD-dependent protein deacetylase, plays a central role in the control of lipid metabolism in nonruminants. However, the role of SIRT1 in hepatic lipid metabolism in dairy cows with fatty liver is not well known. Thus, we used isolated primary bovine hepatocytes to determine the role of SIRT1 in protecting cells against oleic acid (OA)-induced steatosis. Recombinant adenoviruses to overexpress (AD-GFP-SIRT1-E) or knockdown (AD-GFP-SIRT1-N) SIRT1 were used for transduction o...
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#1Li Cao (AAU: Anhui Agricultural University)H-Index: 4
#2Jie Zhao (AAU: Anhui Agricultural University)H-Index: 3
Last. Xichun Wang (AAU: Anhui Agricultural University)H-Index: 13
view all 10 authors...
Zearalenone (ZEA) has an estrogenic effect and often causes reproductive damage. Pigs are particularly sensitive to it. Lycopene (LYC) is a type of fat-soluble natural carotenoid that has antioxidant, anti-inflammatory, anti-cancer, anti-cardiovascular and detoxifying effects. In this study, piglet sertoli cells (SCs) were used as research objects to investigate the mechanism of ZEA induced damage to piglet SCs and to evaluate the protective effect of LYC on ZEA induced toxic damage to piglet SC...
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#1Li Cao (AAU: Anhui Agricultural University)H-Index: 4
#2Jie Zhao (AAU: Anhui Agricultural University)H-Index: 3
Last. Xichun WangH-Index: 13
view all 9 authors...
Zearalenone (ZEA) and Deoxynivalenol (DON) are two mycotoxins highly detected in agricultural products and feed. Both mycotoxins produce reproductive toxicity and pose a serious threat to human and animal health, among which pigs are the most sensitive animals. Sertoli cells (SCs) play an important role in spermatogenesis; however, the combined toxicity of ZEA and DON and the screening of effective protective agents remains to be determined. By studying the effects of N-acetylcysteine (NAC) on t...
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OBJECTIVE Glucose transporter 9 (GLUT9) is a uric acid transporter that is associated with uric absorption in mice and humans; but it is unknown whether GLUT9 involves in chicken uric acid regulation. This experiment aimed to investigate the chicken GLUT9 expression and serum uric acid (SUA) level. METHODS Sixty chickens were divided into 4 groups (n = 15): a control group (NC); a sulfonamide-treated group (SD) supplemented with sulfamonomethoxine sodium via drinking water (8 mg/L); a fishmeal g...
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#1Li Cao (AAU: Anhui Agricultural University)H-Index: 4
#2Yunjing Jiang (AAU: Anhui Agricultural University)H-Index: 4
Last. Xichun Wang (AAU: Anhui Agricultural University)H-Index: 13
view all 11 authors...
Deoxynivalenol (DON) is a common trichothecene mycotoxin found worldwide. DON has broad toxicity towards animals and humans. However, the mechanism of DON-induced neurotoxicity in vitro has not been fully understood. This study investigated the hypothesis that DON toxicity in neurons occurs via the mitochondrial apoptotic pathway. Using piglet hippocampal nerve cells (PHNCs), we evaluated the effects of different concentrations of DON on typical indicators of apoptosis. The obtained results demo...
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#1Hongyan Ding (AAU: Anhui Agricultural University)H-Index: 10
#2Yu Li (AAU: Anhui Agricultural University)H-Index: 18
Last. Jinjie Wu (AAU: Anhui Agricultural University)H-Index: 12
view all 11 authors...
Epigallocatechin-3-gallate (EGCG) plays a crucial role in hepatic lipid metabolism. However, the underlying regulatory mechanism of hepatic lipid metabolism by EGCG in canine is unclear. Primary canine hepatocytes were treated with EGCG (0.01, 0.1, or 1 μM) and BML-275 (an AMP-activated protein kinase [AMPK] inhibitor) to study the effects of EGCG on the gene and protein expressions associated with AMPK signaling pathway. Data showed that treatment with EGCG had greater activation of AMPK, as we...
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#1Shibin Feng (AAU: Anhui Agricultural University)H-Index: 12
#2Hongyan Ding (AAU: Anhui Agricultural University)H-Index: 10
Last. Jinjie Wu (AAU: Anhui Agricultural University)H-Index: 12
view all 12 authors...
The aim of the present study was to investigate the immunoregulatory effects of Astragalus polysaccharide (APS) on RAW264.7 cells. The production of cytokines by RAW264.7 cells was analyzed using ELISA, while cell viability and optimal concentration of APS were assessed using the Cell Counting Kit-8 assay. In addition, the mRNA levels of IL-6, inducible nitric oxide synthase (iNOS) and TNF-α were determined by reverse transcription-quantitative PCR analysis. The levels of co-stimulatory molecule...
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#1Xichun Wang (AAU: Anhui Agricultural University)H-Index: 13
#2Xiaoyan Chu (AAU: Anhui Agricultural University)H-Index: 6
Last. Jinjie Wu (AAU: Anhui Agricultural University)H-Index: 12
view all 11 authors...
Abstract Deoxynivalenol (DON), a type B trichothecene mycotoxin mainly affects the health status of pigs and reduced their growth. This study aimed to determine the effects of PI3K/Akt/mTOR pathway on DON-induced autophagy of piglet hippocampal nerve cells (PHNCs), and the relationship between autophagy and apoptosis. The effects of DON on autophagy of PHNCs were examined by cell morphology, cell viability, apoptosis rate, electron microscopy, transient transfection of GFP-LC3 plasmid, immunoflu...
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#1Sajid Ur Rahman (AAU: Anhui Agricultural University)H-Index: 9
#2Yingying Huang (AAU: Anhui Agricultural University)H-Index: 6
Last. Xichun Wang (AAU: Anhui Agricultural University)H-Index: 13
view all 11 authors...
BACKGROUND Tea polyphenols (TPs) attenuate obesity related liver inflammation; however, the anti-obesity effects and anti-inflammatory mechanisms are not clearly understood. This study aimed to determine whether the anti-obesity and anti-inflammatory TPs mechanisms associated with cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) expression levels, and obesity-related gene response in dogs. RESULTS Dogs fed TPs displayed significantly decreased (p < 0.01) mRNA expression of tum...
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#1Xichun Wang (AAU: Anhui Agricultural University)H-Index: 13
#2Xiaofang Chen (AAU: Anhui Agricultural University)H-Index: 6
Last. Jinjie Wu (AAU: Anhui Agricultural University)H-Index: 12
view all 12 authors...
Abstract Deoxynivalenol(DON) has broad toxicity in livestock, but we know little about its neurotoxic mechanisms. We investigated DON neurotoxicity in the cerebral cortex, cerebellum, and hippocampus of “Duroc × Landrace × Yokshire” piglets. Control piglets were fed a basal diet, while those in low- and high-treatment groups were fed diets with 1.3 mg/kg and 2.2 mg/kg DON, respectively. After a 60 d trial, scanning electron microscopy revealed the destruction of hippocampal cell ultrastructure. ...
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