Ding Yuan
China Three Gorges University
Downregulation and upregulationEndocrinologyMolecular biologyAndrologyTumor necrosis factor alphaChemistryApoptosisSuperoxide dismutaseOxidative stressWestern blotInflammationMalondialdehydeAgeingSenescenceBiochemistrySignal transductionMedicineCell cultureBiologyPharmacology
73Publications
10H-index
239Citations
Publications 51
Newest
#1Yue Shi (CTGU: China Three Gorges University)H-Index: 1
#2Liu Zhengtai (CTGU: China Three Gorges University)
Last. Chengfu Yuan (CTGU: China Three Gorges University)H-Index: 11
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Abstract We aimed to investigate the effects of total saponins from Panax japonicus (TSPJ) on adipocyte inflammation and insulin resistance induced by a high-fat diet (HFD). Moreover, its underlying mechanism was further explored. In vivo, we found that TSPJ inhibited the activation of NF-κB and increase the transcription of p-AKT, leading to reduced inflammation and improved sensitivity of adipocytes to insulin. In vitro evaluation revealed that palmitic acid (PA) induced inflammation by activa...
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#1Jie Zheng (CTGU: China Three Gorges University)H-Index: 1
#2Shanshan Hu (CTGU: China Three Gorges University)H-Index: 1
Last. Zhou Zhiyong (CTGU: China Three Gorges University)H-Index: 9
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Icariin (ICA) is the main active ingredient of Epimedium brevicornu Maxim (Berberidaceae), which is used in the immune, reproductive, neuroendocrine systems, and anti-aging. To evaluate the effect ...
1 CitationsSource
#1Yuhui Guo (CTGU: China Three Gorges University)H-Index: 1
#2Zhihao Cheng (CTGU: China Three Gorges University)
Last. Changcheng Zhang (CTGU: China Three Gorges University)H-Index: 12
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AIM The enteric nervous system degenerates gradually with age, and α-synuclein (α-syn) is a suitable marker of enteric nervous system degeneration, which is intimately related with endoplasmic reticulum stress and unfolded protein response (UPRER ). Saponins from Panax japonicus (SPJ) have obvious protective effects on neurons in several degenerative disease models. Here, the study was designed to investigate whether SPJ could reverse the neuron degeneration through regulating the UPRER in the c...
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#1Yu‐e Qin (CTGU: China Three Gorges University)
#2Li Duan (CTGU: China Three Gorges University)
Last. Liu Chaoqi (CTGU: China Three Gorges University)H-Index: 11
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SCOPE Obesity increases intracellular lipid accumulation in hepatocytes, which can induce non-alcoholic fatty liver disease (NAFLD). With progression of NAFLD, a sizable fraction of patients develop non-alcoholic steatohepatitis (NASH), eventually leading to cirrhosis and hepatocellular carcinoma (HCC). The mechanism involved in obesity-induced NAFLD remains unclear. Free fatty acids and high-fat diets, which induce hepatocyte senescence, are major risk factors for NAFLD. Therefore in this study...
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#1Junhao Zeng (CTGU: China Three Gorges University)H-Index: 1
#2Dengqing Zhang (CTGU: China Three Gorges University)H-Index: 2
Last. Liu Chaoqi (CTGU: China Three Gorges University)H-Index: 11
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SCOPE The over-activation of the nucleotide-binding domain like receptor protein 3 (NLRP3) inflammasome plays an important role in the pathogenesis of ulcerative colitis (UC). Chlorogenic acid (CGA) exposure is identified as an effective strategy for repressing inflammatory responses. METHODS AND RESULTS In this study, the NLRP3 inflammasome model with LPS/ATP-induced RAW264.7 cells in vitro and dextran-sulfate-sodium (DSS)-induced colitis in mice are used to evaluate the effect of CGA on NLRP3 ...
5 CitationsSource
#1Zhou Zhiyong (CTGU: China Three Gorges University)H-Index: 9
#2Menghan He (CTGU: China Three Gorges University)
Last. Ting Wang (WUST: Wuhan University of Science and Technology)
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#1Yuan Yang (CTGU: China Three Gorges University)
#2Changcheng Zhang (CTGU: China Three Gorges University)H-Index: 12
Last. Haixia Zhao (CTGU: China Three Gorges University)H-Index: 7
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#1Yi Xin (CTGU: China Three Gorges University)H-Index: 1
#2Qin Yuan (CTGU: China Three Gorges University)H-Index: 3
Last. Ding Yuan (CTGU: China Three Gorges University)H-Index: 10
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1 CitationsSource
#2Ding YuanH-Index: 10
Last. Chengfu YuanH-Index: 11
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#1Haixia Zhao (CTGU: China Three Gorges University)H-Index: 7
#2Xu You (CTGU: China Three Gorges University)H-Index: 1
Last. Ding Yuan (CTGU: China Three Gorges University)H-Index: 10
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Sertoli cells play crucial roles in spermatogenesis and are impaired by aging. Icariin, a flavonoid from Epimedium, has been reported to exhibit anti-aging effects and improve testicular dysfunction in the clinical setting. However, whether icariin improves age-related degeneration of testicular function via protection from Sertoli cell injury remains unclear. In the present study, we evaluated the protective effect of icariin on Sertoli cell injury and explored the possible mechanism(s) in vivo...
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