Xiao-Bing Wang
China Pharmaceutical University
Chirality (chemistry)Circular dichroismInhibitory postsynaptic potentialOrganic chemistryChemistryIn vitroAbsolute configurationNeuroprotectionMoietyIC50AntioxidantAcetylcholinesteraseRing (chemistry)MeliaceaeCholinesteraseTerpeneBiochemistryNuclear magnetic resonance spectroscopyStereochemistryPharmacology
236Publications
31H-index
3,387Citations
Publications 213
Newest
#1Peng-Ran Cao (CPU: China Pharmaceutical University)
#2Yi-Lei Zheng (CPU: China Pharmaceutical University)
Last. Ling-Yi Kong (CPU: China Pharmaceutical University)H-Index: 58
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Two novel natural products, beetleane A (1) and epicoane A (2), were obtained from the metabolites of an endophytic Epicoccum nigrum. Compound 1 has a unique beetlelike structure that is constructed by the fusion and further fold of an unusual [5.5.5.6]trioxafenestrane with a cycloheptane ring. Compound 2 possesses a compact cagelike structure with a unique 6/5/5/5/6/6/5 heptacyclic ring system. Both 1 and 2 showed strong antiliver fibrosis activity in vitro.
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#1Lai-Liang Qu (CPU: China Pharmaceutical University)H-Index: 2
#2Limei Ji (CPU: China Pharmaceutical University)H-Index: 1
Last. Xiao-Bing Wang (CPU: China Pharmaceutical University)H-Index: 31
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Abstract Cumulative evidence suggests that β-amyloid and oxidative stress are closely related with each other and play key roles in the process of Alzheimer’s disease (AD). Multitarget regulation of both pathways might represent a promising therapeutic strategy. Here, a series of selenium-containing compounds based on ebselen and verubecestat were designed and synthesized. Biological evaluation showed that 13f exhibited good BACE-1 inhibitory activity (IC50 = 1.06 μΜ) and potent GPx-like activit...
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#1Wan PengH-Index: 1
#2Qiao-Hong LiuH-Index: 7
Last. Xiao-Bing WangH-Index: 31
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1 CitationsSource
#1Hua-Li Yang (SPU: Shenyang Pharmaceutical University)H-Index: 6
#1Hua-Li Yang (SPU: Shenyang Pharmaceutical University)H-Index: 1
Last. Ling-Yi Kong (SPU: Shenyang Pharmaceutical University)H-Index: 58
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Abstract NUAK, the member of AMPK (AMP-activated protein kinase) family of protein kinases, is phosphorylated and activated by the LKB1 (liver kinase B1) tumor suppressor protein kinase. Recent work has indicated that NUAK1 is a key component of the antioxidant stress response pathway, and the inhibition of NUAK1 will suppress the growth and survival of colorectal tumors. As a promising target for anticancer drugs, few inhibitors of NUAK were developed. With this goal in mind, based on NUAK inhi...
1 CitationsSource
#1Limei Ji (CPU: China Pharmaceutical University)H-Index: 1
#2Lai-Liang Qu (CPU: China Pharmaceutical University)H-Index: 2
Last. Xiao-Bing Wang (CPU: China Pharmaceutical University)H-Index: 31
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Abstract Oxidative stress and inflammation are significant risk factors for neurodegenerative disease. The Keap1-Nrf2-ARE pathway is one of the most promising defensive systems against oxidative stress. Here, dozens of piperlongumine analogues were designed, synthesized, and tested on PC12 cells to examine neuroprotective effects against H2O2 and 6-OHDA induced damage. Among them, 6d was found to be able to alleviate the accumulation of ROS, inhibit the production of NO and downregulate the leve...
2 CitationsSource
#1Wenxiu Cao (CPU: China Pharmaceutical University)H-Index: 2
#2Canping Chen (CPU: China Pharmaceutical University)H-Index: 2
Last. Xiao-Bing Wang (CPU: China Pharmaceutical University)H-Index: 31
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2 CitationsSource
#1Cheng WangH-Index: 3
#1Cheng Wang (CPU: China Pharmaceutical University)H-Index: 8
Last. Ling-Yi KongH-Index: 58
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The thioredoxin system plays an important role in cancer cells. Inhibiting thioredoxin reductase (TrxR) has emerged as an effective strategy to selectively target cancer cells. Withangulatin A (WA)...
4 CitationsSource
#1Jinhua ZhaoH-Index: 3
#2Fucheng YinH-Index: 4
Last. Ling-Yi Kong (CPU: China Pharmaceutical University)H-Index: 58
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Alzheimer's disease (AD) is a widespread and burdensome neurodegenerative disease; effective diagnostic methods are lacking, and it remains incurable. The clinical applications of nanoscale metal-organic frameworks (NMOFs) have mainly focused on disease diagnosis and treatment of cancer. A multifunctional NMOF-based nanoplatform was successfully developed for the application in AD diagnosis and therapy. The magnetic nanomaterial Fe-MIL-88B-NH2 was selected to encapsulate methylene blue (MB, a ta...
5 CitationsSource
#1Lin Wu (CPU: China Pharmaceutical University)H-Index: 8
#2Xin Xie (CPU: China Pharmaceutical University)H-Index: 2
Last. Ling-Yi Kong (CPU: China Pharmaceutical University)H-Index: 58
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Abstract Leumelaleucols A-L (1-12), twelve new 5-methoxy-4-methyl-benzyl phloroglucinol-terpenoid hybrids were isolated from the fruits of Melaleuca leucadendron L. The structures were elucidated by analyses of spectral data, and the absolute configurations were determined by the circular dichroism (CD) exciton chirality method. The neuroprotective effects of the isolated compounds were assessed.
2 CitationsSource
#1Yang-Yang Liu (CPU: China Pharmaceutical University)H-Index: 2
#2Zhen Ao (CPU: China Pharmaceutical University)H-Index: 2
Last. Ling-Yi Kong (CPU: China Pharmaceutical University)H-Index: 58
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