Junji Inoue
Osaka Medical College
Enteroendocrine cellGeneMessenger RNAAnatomyRNA-SeqGlycoproteinEye developmentMutation (genetic algorithm)Visual phototransductionGenomeMolecular biologyMedullaGene knockdownDevelopmental biologyPrimordiumChemistryImmunohistochemistryTranscriptional regulationRetinal dysplasiaRetinaGADD45GOptic vesicleAnophthalmiaAdrenal medullaRetinal pigment epitheliumTumor suppressor geneLactoferrinLens (anatomy)ForebrainGastrointestinal tractAmyotrophic lateral sclerosisAdrenal glandEntorhinal cortexRetinalJUNBEmbryonic eyeEye abnormalitySomatic mosaicismEye ProteinsOpsinNon canonicalMorphogenesisEndocrine systemGermline mosaicismPAX6Central nervous systemGeneticsBrainstemGene dosageGene familyChromogranin AIn situ hybridizationBiologyNeuropeptide Y receptorCell biologyOptic cup (embryology)CRISPR
9Publications
4H-index
46Citations
Publications 9
Newest
#2Hitomi HamaokaH-Index: 3
Last. Yoichi Kondo (Shiga University of Medical Science)
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Lactoferrin (Lf) is an iron-binding glycoprotein mainly found in exocrine secretions and the secondary granules of neutrophils. In the central nervous system (CNS), expression of the Lf protein has been reported in the lesions of some neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis, as well as in the aged brain. Lf is primarily considered an iron chelator, protecting cells from potentially toxic iron or iron-requiring microorganisms...
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#1Munenori Habuta (Okayama University)H-Index: 2
#2Hirofumi Fujita (Okayama University)H-Index: 23
Last. Hideyo Ohuchi (Okayama University)H-Index: 56
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REIC (reduced expression in immortalized cells) has been identified as a gene whose expression was reduced in immortalized cultured cells. The REIC gene is identical to Dickkopf-3 (Dkk3), which encodes a secreted glycoprotein belonging to the Dkk family. Previously, we showed that Dkk3 protein is present in the mouse adrenal medulla. However, its role in this tissue has not been elucidated. To explore it, we performed electron microscopic (EM) studies and RNA-sequencing (RNA-seq) analysis on Dkk...
2 CitationsSource
#1Akihiro YasueH-Index: 13
#2Hitomi KonoH-Index: 1
Last. Hideyo OhuchiH-Index: 56
view all 10 authors...
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#1Junji Inoue (Okayama University)H-Index: 4
#2Hirofumi Fujita (Okayama University)H-Index: 23
Last. Hideyo Ohuchi (Okayama University)H-Index: 56
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Dickkopf-related protein 3 (Dkk3) is the third member of the Dkk gene family and identical to the gene, whose expression was reduced in immortalized cells. Therefore, its another name is reduced expression in immortalized cells. Since the intratumoral introduction of Dkk3 inhibits tumor growth in mouse models of cancers, Dkk3 is likely a tumor suppressor gene. However, the functions of Dkk3 in vivo remain unclear. As the first step to decipher the physiological roles of this gene, we examined th...
5 CitationsSource
#1Akihiro Yasue (University of Tokushima)H-Index: 13
#2Hitomi Kono (Okayama University)H-Index: 1
Last. Hideyo Ohuchi (Okayama University)H-Index: 56
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The clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated protein (Cas) system is a rapid gene-targeting technology that does not require embryonic stem cells. To demonstrate dosage effects of the Pax6 gene on eye formation, we generated Pax6-deficient mice with the CRISPR/Cas system. Eyes of founder embryos at embryonic day (E) 16.5 were examined and categorized according to macroscopic phenotype as class 1 (small eye with distinct pigmentation), class 2 (pigmentat...
20 CitationsSource
#1Junji Inoue (Okayama University)H-Index: 4
#2Yuuki Ueda (University of Tokushima)H-Index: 1
Last. Hideyo Ohuchi (Okayama University)H-Index: 56
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Elucidating the mechanisms underlying eye development is essential for advancing the medical treatment of eye-related disorders. The primordium of the eye is an optic vesicle (OV), which has a dual potential for generation of the developing neural retina and retinal pigment epithelium. However, the factors that regulate the differentiation of the retinal primordium remain unclear. We have previously shown that overexpression of Lhx1 and Lhx5, members of the LIM-homeobox genes, induced the format...
11 CitationsSource
#1Takumi Kawaue (University of Tokushima)H-Index: 8
#1Takumi Kawaue (University of Tokushima)H-Index: 1
Last. Hideyo Ohuchi (Okayama University)H-Index: 56
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How the eye forms has been one of the fundamental issues in developmental biology. The retinal anlage first appears as the optic vesicle (OV) evaginating from the forebrain. Subsequently, its distal portion invaginates to form the two-walled optic cup, which develops into the outer pigmented and inner neurosensory layers of the retina. Recent work has shown that this optic-cup morphogenesis proceeds as a self-organizing activity without any extrinsic molecules. However, intrinsic factors that re...
11 CitationsSource
#1Hideyo Ohuchi (University of Tokushima)H-Index: 56
#2Junji Inoue (University of Tokushima)H-Index: 4
Last. Sumihare Noji (University of Tokushima)H-Index: 68
view all 4 authors...
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