Ronald J. Ellis
University of California, San Diego
PsychiatryInternal medicineNeuropsychologyViral loadPathologyOdds ratioPsychologyVirologyCognitionNeurocognitiveImmunologyDiseaseDementiaCerebrospinal fluidAcquired immunodeficiency syndrome (AIDS)PopulationHuman immunodeficiency virus (HIV)MedicineCohortBiology
Publications 404
#1Ni Sun-Suslow (UCSD: University of California, San Diego)H-Index: 3
#2Emily Balon (University of Cincinnati Academic Health Center)
Last. David J. Moore (UCSD: University of California, San Diego)H-Index: 46
view all 8 authors...
Older people with HIV (PWH) experience heightened risk for the acquisition of cumulative, multisystem decline, i.e., frailty syndrome. Frailty relates to poorer sleep quality in the general older adult population; however, this association has yet to be explored among PWH. A cross-sectional analysis of 285 PWH ≥50 years old (mean age 60.5 ± 7.0) examined the relationship between frailty (Fried frailty phenotype) and self-reported sleep quality (Pittsburgh Sleep Quality Index; PSQI). Three separa...
#1Irina A. Strigo (Veterans Health Administration)H-Index: 35
#2John R. Keltner (Veterans Health Administration)H-Index: 5
Last. Alan N. Simmons (Veterans Health Administration)H-Index: 67
view all 4 authors...
#1Ronald J. EllisH-Index: 90
Last. Rob KnightH-Index: 214
view all 9 authors...
People with human immunodeficiency virus (HIV) (PWH) have reduced gut barrier integrity (“leaky gut”) that permits diffusion of microbial antigens (microbial translocation) such as lipopolysaccharide (LPS) into the circulation, stimulating inflammation. A potential source of this disturbance, in addition to gut lymphoid tissue CD4+ T-cell depletion, is the interaction between the gut barrier and gut microbes themselves. We evaluated the relationship of gut barrier integrity, as indexed by plasma...
#1Asante R. Kamkwalala (Johns Hopkins University)H-Index: 2
#2Ankita Garg (UGA: University of Georgia)H-Index: 12
Last. Angela R. Kamer (NYU: New York University)H-Index: 20
view all 18 authors...
The number of people with HIV (PWH) aged 50 years or older continues to steadily increase. The convergence of age- and HIV-related complications in these individuals presents a challenge for both p...
#1Ronald J. Ellis (UCSD: University of California, San Diego)H-Index: 90
#2Robert K. HeatonH-Index: 127
Last. Rob Knight (UCSD: University of California, San Diego)H-Index: 214
view all 5 authors...
Abstract null null Objective: Gut dysbiosis, defined as pathogenic alterations in the distribution and abundance of different microbial species, is associated with neuropathic pain in a variety of clinical conditions, but this has not been explored in the context of neuropathy in people with HIV (PWH). Methods. We assessed gut microbial diversity and dysbiosis in PWH and people without HIV (PWoH), some of whom reported distal neuropathic pain (DNP). DNP was graded on a standardized, validated se...
#1Mary Clare MastersH-Index: 3
#2Jeremiah Perez (Harvard University)H-Index: 5
Last. Kristine M. Erlandson (Anschutz Medical Campus)H-Index: 30
view all 13 authors...
BACKGROUND Neurocognitive impairment (NCI) and frailty are more prevalent among persons with HIV (PWH) compared to those without HIV. Frailty and NCI often overlap with one another. Whether frailty precedes declines in neurocognitive function among PWH or vice versa has not been well-established. SETTING AIDS Clinical Trials Group (ACTG) A5322 is an observational cohort study of older PWH. Participants undergo annual assessments for NCI and frailty. METHODS ACTG A5322 participants who developed ...
#1Monica M. Diaz (UCSD: University of California, San Diego)H-Index: 4
#8Benjamin B. Gelman (UTMB: University of Texas Medical Branch)H-Index: 24
OBJECTIVE Distal sensory polyneuropathy (DSP) is a disabling consequence of HIV, leading to poor quality of life and more frequent falls in older age. Neuropathic pain and paresthesia are prevalent symptoms, however there are currently no known curative treatments and the longitudinal course of pain in HIV-associated DSP is poorly characterized. METHODS This was a prospective longitudinal study of 265 PWH enrolled in the CNS HIV Antiretroviral Therapy Effects Research (CHARTER) study with baseli...
BACKGROUND Neurocognitive impairment (NCI) is associated with monocyte activation in people with HIV (PWH). Activated monocytes increase glycolysis, reduce oxidative phosphorylation and accumulate citrate and succinate, tricarboxylic acid (TCA) cycle metabolites that promote inflammation-this metabolic shift may contribute to NCI and slowed gait speed in PWH. METHODS Plasma citrate and succinate were assayed by liquid chromatography-mass spectrometry from 957 participants upon entry to a multice...
#1Ronald J. Ellis (UCSD: University of California, San Diego)H-Index: 90
#2Natalie L. Wilson (UCSF: University of California, San Francisco)H-Index: 1
Last. Scott N. Peterson (DI: Discovery Institute)H-Index: 40
view all 3 authors...
Persistent inflammation occurs in people with HIV (PWH) and has many downstream adverse effects including myocardial infarction, neurocognitive impairment and death. Because the proportion of people with HIV who use cannabis is high and cannabis may be anti-inflammatory, it is important to characterize the impact of cannabis use on inflammation specifically in PWH. We performed a selective, non-exhaustive review of the literature on the effects of cannabis on inflammation in PWH. Research in thi...
#1Ronald J. Ellis (UCSD: University of California, San Diego)H-Index: 90
#2Emily W Paolillo (UCSD: University of California, San Diego)H-Index: 12
Last. Robert K. Heaton (UCSD: University of California, San Diego)H-Index: 127
view all 4 authors...
BACKGROUND Age-related comorbidities accumulate faster in people with HIV (PWH) than in those without (PWoH). We evaluated whether a validated multimorbidity scale, the Charlson Index, predicted neurocognitive trajectories in PWH. METHODS Scaled scores a comprehensive neuropsychological battery were averaged across all visits. Multilevel modeling examined between- and within-person predictors of global neurocognition. At the between-person level, averaged Charlson scores were examined as a predi...
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