Hisanori Umehara
Kanazawa Medical University
Internal medicineEndocrinologySurgeryPathologyAntibodyApoptosisRheumatologyImmunologyBiopsyRheumatoid arthritisCeramideAutoimmune pancreatitisDiseaseLymphomaIgG4-related diseaseSjogren sSphingomyelinMedicineBiologyGastroenterologyCell biology
157Publications
56H-index
11.4kCitations
Publications 153
Newest
#1Yoshiya TanakaH-Index: 91
#2Tsutomu Takeuchi (Keio: Keio University)H-Index: 84
Last. Toshio ImaiH-Index: 58
view all 13 authors...
Objective To evaluate the efficacy and safety of E6011, a humanized IgG2 monoclonal antibody against human fractalkine (FKN), in a phase II, double-blind, placebo-controlled study in rheumatoid arthritis (RA) patients. Methods Patients with moderate-to-severe RA who had an inadequate response to methotrexate were randomly assigned to a placebo group or to E6011 100-mg, 200-mg, or 400/200-mg groups at a 2:1:2:2 ratio. During the 24-week period, patients received the study drug subcutaneously at w...
1 CitationsSource
#1Yoshiya Tanaka (University of Occupational and Environmental Health Japan)H-Index: 91
#2Tsutomu Takeuchi (Keio: Keio University)H-Index: 84
Last. Toshio ImaiH-Index: 58
view all 13 authors...
OBJECTIVES To evaluate the safety and efficacy of E6011, a novel humanized anti-fractalkine monoclonal antibody, in patients with active rheumatoid arthritis (RA) with an inadequate response to biological disease-modifying antirheumatic drugs (DMARDs). METHODS Active RA patients inadequately responding to biological DMARDs were randomly assigned to placebo or E6011 400-mg group at a 1:1 ratio, and administered E6011 at weeks 0, 1, 2, and subsequently every 2 weeks. Primary endpoint was American ...
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#1Hisanori UmeharaH-Index: 56
#2Kazuichi Okazaki (Kansai Medical University)H-Index: 85
Last. Mitsuhiro Kawano (Kanazawa University)H-Index: 34
view all 10 authors...
IgG4-related disease (IgG4-RD) is a fascinating clinical entity first reported in this century in Japan, and includes a wide variety of diseases, such as formerly named Mikulicz's disease (MD), autoimmune pancreatitis (AIP), interstitial nephritis, prostatitis and retroperitoneal fibrosis. The Japanese IgG4 team organized by the Ministry of Health, Labor and Welfare (MHLW) of Japan has published the first criteria, comprehensive diagnostic (CD) criteria for IgG-RD 2011. Thereafter, IgG4-RD has b...
2 CitationsSource
#1Takuji Nakamura (Kanazawa Medical University)H-Index: 9
#1Takuji NakamuraH-Index: 47
Last. Hisanori Umehara (Kanazawa Medical University)H-Index: 56
view all 28 authors...
AbstractBackground: IgG4-related disease (IgG4-RD) is characterized by elevated serum IgG4 and tissue infiltration by IgG4-positive plasma cells. The pathogenesis of this disease is not clear. Tran...
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#1Zachary S. Wallace (Harvard University)H-Index: 27
#2Ray NadenH-Index: 7
Last. John H. Stone (Harvard University)H-Index: 94
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OBJECTIVE: IgG4-related disease (IgG4-RD) can cause fibroinflammatory lesions in nearly any organ. Correlation among clinical, serologic, radiologic, and pathologic data is required for diagnosis. This work was undertaken to develop and validate an international set of classification criteria for IgG4-RD. METHODS: An international multispecialty group of 86 physicians was assembled by the American College of Rheumatology (ACR) and the European League Against Rheumatism (EULAR). Investigators use...
54 CitationsSource
#1Zachary S. Wallace (Harvard University)H-Index: 27
#2Ray Naden (McMaster University)H-Index: 7
Last. John H. Stone (Harvard University)H-Index: 94
view all 20 authors...
IgG4-related disease (IgG4-RD) can cause fibroinflammatory lesions in nearly any organ. Correlation among clinical, serological, radiological and pathological data is required for diagnosis. This work was undertaken to develop and validate an international set of classification criteria for IgG4-RD. An international multispecialty group of 86 physicians was assembled by the American College of Rheumatology (ACR) and the European League Against Rheumatism (EULAR). Investigators used consensus exe...
109 CitationsSource
#1Chikashi Terao (Kyoto University)H-Index: 32
#2Masao Ota (Shinshu University)H-Index: 1
Last. Chiharu KawanamiH-Index: 21
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Summary Background IgG4-related disease is a newly recognised immunopathological entity that includes autoimmune pancreatitis, IgG4-related sialadenitis, and IgG4-related kidney disease. To understand the genetic landscape of IgG4-related disease, we did a genome-wide association study. Methods We did a genome-wide association study of Japanese individuals, initially screening 857 patients with IgG4-related disease at 50 Japanese research institutions and DNA samples from 2082 healthy control pa...
10 CitationsSource
We appreciate the interest shown by Dr S Fukui and colleagues1 in our recent paper, ‘How to diagnose IgG4-related disease (IgG4-RD)’.2 IgG4-RD is characterised by increased serum IgG4 concentrations and number of IgG4-positive plasma cells in affected lesions.3 However, its diagnosis can be difficult, because clinical signs vary depending on the organs affected. A Japanese team established comprehensive diagnostic criteria for IgG4-RD, 2011 focusing on the concentration of serum IgG4 (>135 mg/dL...
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#1Yoshiya Tanaka (University of Occupational and Environmental Health Japan)H-Index: 91
#2Tsutomu Takeuchi (Keio: Keio University)H-Index: 84
Last. Toshio ImaiH-Index: 58
view all 13 authors...
Background Fractalkine (CX3CL1, designated as FKN hereafter) is the sole member of the CX3C-chemokine which leads to dual actions, chemotaxis and cell adhesion for leukocytes expressing the cognate receptor, CX3CR1, during their migration. We have conducted clinical trials of E6011, a novel humanized anti-FKN monoclonal antibody, for patients with rheumatoid arthritis (RA) in Japan1. This is the first report of a Phase 2, multicenter, randomized, double-blind, placebo-controlled, parallel-group ...
2 CitationsSource
#1Yoshiya Tanaka (University of Occupational and Environmental Health Japan)H-Index: 91
#2Tsutomu Takeuchi (Keio: Keio University)H-Index: 84
Last. Toshio ImaiH-Index: 58
view all 13 authors...
Background Fractalkine (CX3CL1, designated as FKN hereafter) is the sole member of the CX3C-chemokine which leads to dual actions, chemotaxis and cell adhesion for leukocytes expressing the cognate receptor, CX3CR1, during their migration. We have conducted clinical trials of E6011, a novel humanized anti-FKN monoclonal antibody, for patients with rheumatoid arthritis (RA) in Japan 1 . This is the first report of efficacy and safety results of E6011 from a Phase 2, multicenter, randomized, doubl...
4 CitationsSource