Lu Lan
Boston University
Photoacoustic tomographyTemporal resolutionOpticsPhysicsRadiologyDielectricBiomedical engineeringUltrasoundMicroscopyNeuromodulation (medicine)Photoacoustic effectPhotothermal therapyElectrophysiologyMaterials scienceImage resolutionCloakLumpectomyBreast tumorComputer scienceOptoelectronicsLaserBreast cancerTransducerCloakingMicroscopeMedicineTransformation optics
41Publications
12H-index
565Citations
Publications 33
Newest
#1Linli Shi (BU: Boston University)H-Index: 1
#2Ying Jiang (BU: Boston University)H-Index: 4
Last. Chen Yang (BU: Boston University)H-Index: 69
view all 9 authors...
Neuromodulation at high spatial resolution poses great significance in advancing fundamental knowledge in the field of neuroscience and offering novel clinical treatments. Here, we developed a tapered fiber optoacoustic emitter (TFOE) generating an ultrasound field with a high spatial precision of 39.6 µm, enabling optoacoustic activation of single neurons or subcellular structures, such as axons and dendrites. Temporally, a single acoustic pulse of sub-microsecond converted by the TFOE from a s...
Source
#1Jiaze Yin (BU: Boston University)
#2Lu Lan (BU: Boston University)H-Index: 12
Last. Ji-Xin Cheng (BU: Boston University)H-Index: 83
view all 6 authors...
Mid-infrared photothermal (MIP) microscopy overcomes the resolution and huge water background limits in conventional mid-infrared imaging by probing the mid-infrared absorption induced photothermal effect. However, to detect the subtle MIP signal, large probe power and lock-in detection are needed, which limit the imaging speed of current MIP systems. To overcome this limitation, we develop a single-pixel pump-probe camera that leverages the large well-depth capacity of photodiode to achieve hig...
Source
#1Ying Jiang (BU: Boston University)H-Index: 4
#2Yimin Huang (BU: Boston University)H-Index: 10
Last. Lu Lan (BU: Boston University)H-Index: 12
view all 15 authors...
Summary Neuromodulation is an invaluable approach for the study of neural circuits and clinical treatment of neurological diseases. Here, we report semiconducting polymer nanoparticles based photoacoustic nanotransducers (PANs) for neural stimulation in vitro and in vivo. Our PANs strongly absorb the nanosecond pulsed laser in the near-infrared second window (NIR-II) and generate localized acoustic waves. PANs are shown to be surface modified and selectively bind onto neurons. PAN-mediated activ...
1 CitationsSource
#1Linli Shi (BU: Boston University)H-Index: 1
#2Ying Jiang (BU: Boston University)H-Index: 4
Last. Chen Yang (BU: Boston University)H-Index: 69
view all 9 authors...
As an emerging technology, transcranial focused ultrasound has been demonstrated to successfully evoke motor responses in mice, rabbits, and sensory/motor responses in humans. Yet, the spatial resolution of ultrasound does not allow for high-precision stimulation. Here, we developed a tapered fiber optoacoustic emitter (TFOE) for optoacoustic stimulation of neurons with an unprecedented spatial resolution of 20 microns, enabling selective activation of single neurons or subcellular structures, s...
#1Linli Shi (BU: Boston University)H-Index: 1
#2Ying Jiang (BU: Boston University)H-Index: 4
Last. Chen Yang (BU: Boston University)H-Index: 69
view all 7 authors...
Abstract Focused ultrasound has attracted great attention in minimally invasive therapeutic and mechanism studies. Frequency below 1 MHz is identified preferable for high-efficiency bio-modulation. However, the poor spatial confinement of several millimeters and large device diameter of ∼25 mm of typical sub-MHz ultrasound technology suffered from the diffraction limit, severely hindering its further applications. To address it, a fiber-based optoacoustic emitter (FOE) is developed, serving as a...
4 CitationsSource
#1Lu Lan (BU: Boston University)H-Index: 12
#2Yueming Li (BU: Boston University)H-Index: 1
Last. Ji-Xin Cheng (BU: Boston University)H-Index: 83
view all 6 authors...
Microwaves, which have a ∼10-cm wavelength, can penetrate deeper into tissue than photons, heralding exciting deep tissue applications such as modulation or imaging via the thermoacoustic effect. Thermoacoustic conversion efficiency is however very low, even with an exogenous contrast agent. We break this low-conversion limit, using a split ring resonator to effectively collect and confine the microwaves into a submillimeter hot spot for ultrasound emission and achieve a conversion efficiency ov...
2 CitationsSource
#1Ying Jiang (BU: Boston University)H-Index: 4
#2Hyeon Jeong LeeH-Index: 10
Last. Ji-Xin ChengH-Index: 83
view all 8 authors...
Low-intensity ultrasound is an emerging modality for neuromodulation. Yet, transcranial neuromodulation using low-frequency piezo-based transducers offers poor spatial confinement of excitation volume, often bigger than a few millimeters in diameter. In addition, the bulky size limits their implementation in a wearable setting and prevents integration with other experimental modalities. Here, we report spatially confined optoacoustic neural stimulation through a miniaturized Fiber-Optoacoustic C...
15 CitationsSource
#1Delong Zhang (ZJU: Zhejiang University)H-Index: 21
#2Lu Lan (BU: Boston University)H-Index: 12
Last. Ji-Xin Cheng (BU: Boston University)H-Index: 83
view all 7 authors...
Phase-contrast microscopy converts the phase shift of light passing through a transparent specimen, e.g., a biological cell, into brightness variations in an image. This ability to observe structures without destructive fixation or staining has been widely utilized for applications in materials and life sciences. Despite these advantages, phase-contrast microscopy lacks the ability to reveal molecular information. To address this gap, we developed a bond-selective transient phase (BSTP) imaging ...
30 CitationsSource
#1Lu LanH-Index: 12
#2Yueming LiH-Index: 1
Last. Ji-Xin Cheng (BU: Boston University)H-Index: 83
view all 5 authors...
Thermo-elastic conversion of electromagnetic wave into ultrasound wave has enabled diverse biomedical applications such as photoacoustic imaging. Microwave, which has ~10 cm long wavelength, can penetrate deeper into tissue than photons, heralding exciting applications such as deep tissue imaging via thermo-acoustic tomography. However, the thermo-acoustic conversion efficiency is very low even with an exogenous contrast agent such as carbon nanotube. Here, we break this low conversion limit thr...
#1Linli ShiH-Index: 1
#2Ying JiangH-Index: 4
Last. Chen YangH-Index: 69
view all 7 authors...
Focused ultrasound has attracted great attention in minimally invasive therapy, gene delivery, brain stimulation, etc. Frequency below 1 MHz has been identified preferable for high-efficacy drug delivery, gene transfection and neurostimulation due to minimized tissue heating and cell fragmentation. However, the poor spatial resolution of several millimeters and the large device diameter of ~25 mm of current sub-MHz ultrasound technology severely hinders its further applications for effective, pr...