Joshua D. Simpson
University of Queensland
Ligand (biochemistry)BiophysicsAptamerCellNanomedicineNanotechnologyAvidityNanocarriersChemistryMaterials scienceEpitopeIn vivoBioconjugationEpidermal growth factor receptorDrug deliveryProstate cancerDoxorubicinHyperbranched polymersComputer scienceCancer researchPEG ratioRaftDistribution (pharmacology)
14Publications
7H-index
166Citations
Publications 13
Newest
The ability to predict the behaviour of polymeric nanomedicines can often be obfuscated by subtle modifications to the corona structure, such as incorporation of fluorophores or other entities. However, these interactions provide an intriguing insight into how selection of molecular components in multifunctional nanomedicines contributes to the overall biological fate of such materials. Here, we detail the internalisation behaviours of polymeric nanomedicines across a suite of cell types and ext...
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#1Joshua D. Simpson (UQ: University of Queensland)H-Index: 7
#2Patrícia F. Monteiro (University of Nottingham)H-Index: 3
Last. Kristofer J. Thurecht (UQ: University of Queensland)H-Index: 38
view all 9 authors...
Improving our understanding of how design choices in materials synthesis impact biological outcomes is of critical importance in the development of nanomedicines. Here, we show that fluorophore lab...
1 CitationsSource
#1Gayathri R. Ediriweera (UQ: University of Queensland)H-Index: 2
#2Joshua D. Simpson (UQ: University of Queensland)H-Index: 7
Last. Kristofer J. Thurecht (UQ: University of Queensland)H-Index: 38
view all 12 authors...
There remain several key challenges to existing therapeutic systems for cancer therapy, such as quantitatively determining the true, tissue-specific drug release profile in vivo, as well as reducing side-effects for an increased standard of care. Hence, it is crucial to engineer new materials that allow for a better understanding of the in vivo pharmacokinetic/pharmacodynamic behaviours of therapeutics. We have expanded on recent “click-to-release” bioorthogonal pro-drug activation of antibody-d...
7 CitationsSource
#1Dewan T. Akhter (UQ: University of Queensland)H-Index: 2
#1Dewan T. Akhter (UQ: University of Queensland)H-Index: 2
Last. Kristofer J. Thurecht (UQ: University of Queensland)H-Index: 38
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Nanomaterials for targeted delivery of chemotherapeutics have received significant attention owing to their potential to enhance the accumulation of therapeutics in diseased tissue. However, in diseases with poor vascularization, such as colorectal cancer (CRC), intravenously injected materials have reduced access to the site of interest. To overcome this challenge, oral administration of targeted nanomedicines is highly desirable. Here, a multicomponent drug delivery system incorporating a degr...
5 CitationsSource
#1Joshua D. Simpson (UQ: University of Queensland)H-Index: 7
#2Gayathri R. Ediriweera (UQ: University of Queensland)H-Index: 2
Last. Kristofer J. Thurecht (UQ: University of Queensland)H-Index: 38
view all 6 authors...
As polymeric nanomedicines grow increasingly complex in design, an effective therapeutic release is often inherently tied to localisation to specific intracellular compartments or microenvironments. The inclusion of environmentally-sensitive moieties links the functionality of such materials to the trafficking behaviours exhibited once materials have obtained access to the cellular milieu. In order to perform their designed function, such materials often need to encounter specific biological cue...
5 CitationsSource
#1Joshua D. Simpson (UQ: University of Queensland)H-Index: 7
#2Samuel A Smith (University of Melbourne)H-Index: 3
Last. Georgina K. Such (University of Melbourne)H-Index: 44
view all 4 authors...
Nanomedicine has generated significant interest as an alternative to conventional cancer therapy due to the ability for nanoparticles to tune cargo release. However, while nanoparticle technology has promised significant benefit, there are still limited examples of nanoparticles in clinical practice. The low translational success of nanoparticle research is due to the series of biological roadblocks that nanoparticles must migrate to be effective, including blood and plasma interactions, clearan...
12 CitationsSource
#1Nicholas L. Fletcher (UQ: University of Queensland)H-Index: 14
#2Zachary H. Houston (UQ: University of Queensland)H-Index: 12
Last. Kristofer J. Thurecht (UQ: University of Queensland)H-Index: 38
view all 5 authors...
We report a novel multifunctional hyperbranched polymer based on polyethylene glycol (PEG) as a nanomedicine platform that facilitates longitudinal and quantitative 89Zr-PET imaging, enhancing knowledge of nanomaterial biodistribution and pharmacokinetics/pharmacodynamics both in vivo and ex vivo. Anti-VEGF-A DNA aptamer functionalization increased tumour accumulation by >2-fold in a breast cancer model.
16 CitationsSource
#1Liyu ChenH-Index: 6
#2Joshua D. SimpsonH-Index: 7
Last. Kristofer J. ThurechtH-Index: 38
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Nanoscaled polymeric materials are increasingly being investigated as pharmaceutical products, drug/gene delivery vectors, or health-monitoring devices. Surface charge is one of the dominant parameters that regulates nanomaterial behavior in vivo. In this paper, we demonstrated how control over chemical synthesis allowed manipulation of nanoparticle surface charge, which in turn greatly influenced the in vivo behavior. Three methacrylate/methacrylamide-based monomers were used to synthesize well...
30 CitationsSource
#1Amanda K. Pearce (UQ: University of Queensland)H-Index: 11
#2Joshua D. Simpson (UQ: University of Queensland)H-Index: 7
Last. Kristofer J. Thurecht (UQ: University of Queensland)H-Index: 38
view all 8 authors...
Abstract The therapeutic potential of hyperbranched polymers targeted to prostate cancer and loaded with doxorubicin was investigated. Polyethylene glycol hyperbranched polymers were synthesised via RAFT polymerisation to feature glutamate urea targeting ligands for PSMA on the periphery. The chemotherapeutic, doxorubicin, was attached to the hyperbranched polymers through hydrazone formation, which allowed controlled release of the drug from the polymers in vitro endosomal conditions, with 90% ...
34 CitationsSource
#1Yongmei Zhao (UQ: University of Queensland)H-Index: 5
#2Zachary H. Houston (UQ: University of Queensland)H-Index: 12
Last. Kristofer J. Thurecht (UQ: University of Queensland)H-Index: 38
view all 8 authors...
Theranostics is a strategy that combines multiple functions such as targeting, stimulus-responsive drug release, and diagnostic imaging into a single platform, often with the aim of developing personalized medicine.1,2 Based on this concept, several well-established hyperbranched polymeric theranostic nanoparticles were synthesized and characterized as model nanomedicines to investigate how their properties affect the distribution of loaded drugs at both the cell and whole animal levels. An 8-me...
25 CitationsSource