Greg Sadler
John Radcliffe Hospital
Internal medicineRadiologyEndocrinologySurgeryPathologyLoss of heterozygosityCardiothoracic surgeryProspective cohort studyHyperparathyroidismVascular surgeryParathyroidectomyCardiac surgeryPrimary hyperparathyroidismMEN1PheochromocytomaAdrenalectomyMultiple endocrine neoplasiaAbdominal surgeryParathyroid adenomaParathyroid neoplasmCost effectivenessCancer researchThyroidMedicineMissense mutationBiology
Publications 14
#1Georgia NtaliH-Index: 11
#2Paul J NeweyH-Index: 13
Last. Rajesh ThakkerH-Index: 3
view all 9 authors...
#1Tarek Ezzat Abdel-Aziz (Alexandria University)H-Index: 3
Last. Radu MihaiH-Index: 27
view all 5 authors...
Background Adrenocortical cancer (ACC) is a rare malignancy. In the absence of metastatic disease, the suspicion of ACC is based on size and radiological appearance. The aim of this study was to analyse the long-term outcome of patients with large adrenal cortical tumours (>8 cm).
10 CitationsSource
#1Auditi Naziat (Churchill Hospital)H-Index: 2
#2Niki Karavitaki (Churchill Hospital)H-Index: 38
Last. Brian Shine (University of Oxford)H-Index: 23
view all 10 authors...
19 CitationsSource
#1P J Newey (John Radcliffe Hospital)H-Index: 1
#2M A Nesbit (University of Oxford)H-Index: 4
Last. Rajesh V. Thakker (University of Oxford)H-Index: 95
view all 14 authors...
Context: Genetic abnormalities, such as those of multiple endocrine neoplasia type 1 (MEN1) and Cyclin D1 (CCND1) genes, occur in <50% of nonhereditary (sporadic) parathyroid adenomas. Objective: To identify genetic abnormalities in nonhereditary parathyroid adenomas by whole-exome sequence analysis. Design: Whole-exome sequence analysis was performed on parathyroid adenomas and leukocyte DNA samples from 16 postmenopausal women without a family history of parathyroid tumors or MEN1 and in whom ...
80 CitationsSource
#1Jordan S T Bowen (Wexham Park Hospital)H-Index: 1
#2Andrew ParkerH-Index: 4
view all 7 authors...
A 56-year-old man was found to have an adrenal incidentaloma on a CT scan of the abdomen. Clinically and biochemically, the mass was not functional. MRI scan revealed a heterogeneously enhancing, T2-hyperintense, right-sided adrenal mass (4.5×6.5 cm). Meta-iodo-benzylguanidine scan was normal, making a diagnosis of pheochromocytoma unlikely. As the mass was larger that 4 cm, it was excised and histopathological examination revealed a rare, composite tumour: benign adrenal adenoma with haemangiom...
3 CitationsSource
#2Greg SadlerH-Index: 8
#1Radu Mihai (John Radcliffe Hospital)H-Index: 27
#2Mary Weisters (John Radcliffe Hospital)H-Index: 2
Last. Greg Sadler (John Radcliffe Hospital)H-Index: 8
view all 5 authors...
Background Concordant parathyroid localization with sestamibi and ultrasound scans allows minimally invasive parathyroidectomy (MIP) to be performed in patients with non-familial primary hyperparathyroidism (PHPT).
11 CitationsSource
#1Radu Mihai (John Radcliffe Hospital)H-Index: 27
#2Fergus V. Gleeson (Churchill Hospital)H-Index: 58
Last. Greg Sadler (John Radcliffe Hospital)H-Index: 8
view all 5 authors...
Background Functional imaging using 123I-meta-iodo-benzyl-guanetidine (MIBG) scintigraphy has alleged 100% specificity for phaeochromocytoma (PHAEO). Its benefit in patients with biochemical diagnosis of PHAEO is arguable when cross-sectional radiology can demonstrate the side–size of the adrenal tumours.
16 CitationsSource
#1Fadil M. Hannan (University of Oxford)H-Index: 21
#2M. Andrew Nesbit (University of Oxford)H-Index: 28
Last. Rajesh V. Thakker (University of Oxford)H-Index: 95
view all 7 authors...
Primary hyperparathyroidism is hereditary in 10% of patients. This article describes a patient with familial isolated hyperparathyroidism (FIHP) caused by a novel MEN1 missense mutation. The genetics, differential diagnosis and management of hereditary hyperparathyroidism are illustrated.
76 CitationsSource
#1Radu MihaiH-Index: 27
Last. Greg SadlerH-Index: 8
view all 5 authors...