Ryuji Kiyama
Hokkaido University
OsseointegrationPenetration (firestop)Composite numberSelf-healing hydrogelsMorphology (linguistics)MicroelectrodeUltimate tensile strengthElectrostaticsSoft lithographyBiophysicsBiomedical engineeringBrittlenessDeformation (engineering)Poisson's ratioCharge densityComposite materialPoromechanicsIsotropyChemistryIsotopes of calciumScatteringMaterials scienceModulusFlatteningSurface layerLithographyHybrid materialSurface (mathematics)X-ray microtomographyTougheningBone tissueLayer (electronics)Surface chargeCartilageMechanism (sociology)Flexibility (anatomy)CoatingOsteoid tissueImmature BoneSoft materialsFatigue resistanceOsteoblast adhesionSoft solidsGel matrixBone bondingVideo microscopyDouble networkAcid gelElongationThermal diffusivityElastomerSubstrate (electronics)Chemical engineeringDeformation (mechanics)Tissue engineeringPolymerAmorphous solidBiofoulingMineralization (biology)Absorption (chemistry)Surface stressAdhesionAnisotropyFixation (histology)ToughnessDissipative system
14Publications
6H-index
189Citations
Publications 16
Newest
#1Ryuji Kiyama (Hokkaido University)H-Index: 6
#2Takayuki Nonoyama (Hokkaido University)H-Index: 24
Last. Jian Ping Gong (Hokkaido University)H-Index: 81
view all 5 authors...
Hydrogels are promising materials for several applications, including cell scaffolds and artificial load-bearing substitutes (cartilages, ligaments, tendons, etc.). Direct observation of the nanoscale polymer network of hydrogels is essential in understanding its properties. However, imaging of individual network strands at the molecular level is not achieved yet due to the lack of suitable methods. Herein, for the first time, we developed a novel mineral-staining method and network fixation met...
Source
#1Takayuki Nonoyama (Hokkaido University)H-Index: 24
#2Lei Wang (Hokkaido University)H-Index: 19
Last. Jian Ping Gong (Hokkaido University)H-Index: 81
view all 8 authors...
Source
#1Zezhou Liu (Cornell University)H-Index: 8
#2Chung-Yuen Hui (Hokkaido University)H-Index: 74
Last. Ryuji Kiyama (Hokkaido University)H-Index: 6
view all 5 authors...
When a poroelastic gel is released from a patterned mold, surface stress drives deformation and solvent migration in the gel and flattens its surface profile in a time-dependent manner. Specifically, the gel behaves like an incompressible solid immediately after removal from the mold, and becomes compressible as the solvent is able to squeeze out of the polymer network. In this work, we use the finite element method (FEM) to simulate this transient surface flattening process. We assume that the ...
Source
#1Yong Zheng (Hokkaido University)H-Index: 3
#2Ryuji Kiyama (Hokkaido University)H-Index: 6
Last. Jian Ping Gong (Hokkaido University)H-Index: 81
view all 10 authors...
High modulus, toughness, and fatigue resistance are usually difficult to be obtained simultaneously in rubbery materials. Here, we report that by superimposing the nanophase separation structure in...
Source
#1Takayuki Nonoyama (Hokkaido University)H-Index: 24
#2Lei Wang (Hokkaido University)H-Index: 19
Last. Jian Ping Gong (Hokkaido University)H-Index: 81
view all 13 authors...
Tough double network (DN) hydrogels are promising substitutes of soft supporting tissues such as cartilage and ligaments. For such applications, it is indispensable to robustly fix the hydrogels to bones with medically feasible methods. Recently, robustly bonding the DN hydrogels to defected bones of rabbits in vivo has been proved successful. The low crystalline hydroxyapatite (HAp) of calcium-phosphate-hydroxide salt coated on the surface layer of the DN hydrogels induced spontaneous osteogene...
Source
#1Tomáš SedlačíkH-Index: 1
#2Takayuki NonoyamaH-Index: 24
Last. Jian Ping GongH-Index: 81
view all 8 authors...
Source
#1Chung-Yuen Hui (Hokkaido University)H-Index: 74
#2Zezhou Liu (Cornell University)H-Index: 8
Last. Jian Ping Gong (Hokkaido University)H-Index: 81
view all 8 authors...
The surface of soft solids carries a surface stress that tends to flatten surface profiles. For example, surface features on a soft solid, fabricated by moulding against a stiff-patterned substrate...
Source
#1Tomáš SedlačíkH-Index: 1
#2Takayuki NonoyamaH-Index: 24
Last. Jian Ping GongH-Index: 81
view all 8 authors...
Supermacroporous hydrogels, possessing sponge-like structure and permeability, have drawn significant attention for their bioengineering and biomedical applications. However, their mechanical weakn...
Source
#1Kazuki Fukao (Hokkaido University)H-Index: 4
#2Kazuki Tanaka (Hokkaido University)H-Index: 4
Last. Jian Ping Gong (Hokkaido University)H-Index: 81
view all 5 authors...
Inspired by bone tissues, hydrogels toughened by hydroxyapatite (HAp) working as energy-dissipative sacrifical bonds is created. The contribution of dissipated energy from HAp mineral was over 500 % higher than that from polymer in tensile deformation. This result implies that not only brittle polymer network but also mineral can work as sacrificial bond to toughen soft materials.
Source
#1Honglei Guo (SYSU: Sun Yat-sen University)H-Index: 1
#2Yuto Uehara (Hokkaido University)H-Index: 1
Last. Takayuki Kurokawa (Hokkaido University)H-Index: 58
view all 9 authors...
Soft tissue engineering requires antifouling materials that are biocompatible and mechanically flexible. Conventional hydrogels containing more than 70 wt% water are thus promising antifouling material candidates. However, some hydrogels are difficult to apply in internal body organs because of undesirable protein absorption on their surfaces. Due to the lack of an effective method for observing the true charge densities of hydrogels, the reason why electrostatic interactions dominate protein ab...
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