Barbara Vischioni
European Institute of Oncology
Relative biological effectivenessInternal medicineRadiologySurgeryOncologyChemistryMaterials scienceMedical physicsParticle therapyProton therapyProstate cancerChordomaCarbon Ion RadiotherapyCarbon ionNuclear medicineIn patientRadiation therapyClinical trialProtonMedicine
Publications 96
#1Raffaella CambriaH-Index: 16
#2Delia CiardoH-Index: 15
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Objective:To compare different stereotactic body techniques—intensity-modulated radiotherapy with photons and protons, applied to radiotherapy of prostatic cancer—with simultaneous integrated boost...
PURPOSE OF REVIEW To give an overview of recent advances in therapeutic approaches of radiation-induced salivary gland cancers (ri-SGCs). RECENT FINDINGS Reirradiation with protons and carbon ions demonstrated to be feasible, safe and to offer good local control rates, with the possibility of overcoming radioresistance and dosimetric issues in previously irradiated cancer patients. Chromosomal rearrangements, gene fusions and expression profiles are important to identify specific cancer subtypes...
Clinical data of ri-SGCs patients treated between 2015 and 2019 at a tertiary cancer center and a national hadron therapy facility were reviewed. Latent time (LT) from first RT to ri-SGCs diagnosis, overall (OS), and disease-free survival (DFS) were assessed. Thirteen patients developed 14 ri-SGCs (one patient had 2 synchronous ri-SCGs), after a median LT of 23 years (range 16–34). Parotid was the primary site in 8 cases (57%) and salivary duct carcinoma was the most frequent histotype (29%). Ni...
#1M. FischettiH-Index: 5
#2Guido Baroni (Polytechnic University of Milan)H-Index: 28
Last. Alessio SartiH-Index: 119
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The high dose conformity and healthy tissue sparing achievable in Particle Therapy when using C ions calls for safety factors in treatment planning, to prevent the tumor under-dosage related to the possible occurrence of inter-fractional morphological changes during a treatment. This limitation could be overcome by a range monitor, still missing in clinical routine, capable of providing on-line feedback. The Dose Profiler (DP) is a detector developed within the INnovative Solution for In-beam Do...
1 CitationsSource
#1J.E. Dale (University of Bergen)H-Index: 1
#1Jon Espen Dale (University of Bergen)H-Index: 4
Last. Piero FossatiH-Index: 18
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Background and Purpose The Italian National Center of Oncological Hadrontherapy (CNAO) has applied dose constraints for carbon ion RT (CIRT) as defined by Japan's National Institute of Radiological Sciences (NIRS). However, these institutions use different models to predict the relative biological effectiveness (RBE). CNAO applies the Local Effect Model I (LEM I), which in most clinical situations predicts higher RBE than NIRS's Microdosimetric Kinetic Model (MKM). Equal constraints therefore be...
#1Daniela AlterioH-Index: 21
#2Irene Turturici (IEO: European Institute of Oncology)H-Index: 3
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Abstract Aim To provide a literature review on risk factors and strategies to prevent acute carotid blowout (CBO) syndrome in patients who underwent reirradiation (reRT) for recurrent head and neck (HN) malignancies. Patients and Methods Inclusion criteria were: 1) CBO following reRT in the HN region, 2) description on patient-, tumor- or treatment-related risk factors, 3) clinical or radiological signs of threatened or impending CBO, and 4) CBO prevention strategies. Results Thirty-five studies...
#1Barbara VischioniH-Index: 14
#2Alfredo MirandolaH-Index: 15
Last. Francesca ValvoH-Index: 15
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#1Sara RonchiH-Index: 10
#2Barbara VischioniH-Index: 14
Last. Francesca ValvoH-Index: 15
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#1Alberto IannalfiH-Index: 11
#2E. D’IppolitoH-Index: 4
Last. Roberto Orecchia (IEO: European Institute of Oncology)H-Index: 71
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BACKGROUND: The aim of this study is to evaluate results in terms of local control (LC), overall survival (OS) and toxicity profile and to better identify factors influencing clinical outcome of skull base chordoma treated with proton therapy (PT) and carbon ion therapy (CIRT). METHODS: We prospectively collected and analyzed data of 135 patients treated between 11/2011 and 12/2018. Total prescription dose in PT group (70 patients) and CIRT group (65 patients) was 74 Gy(RBE) delivered in 37 frac...
6 CitationsSource