Da Wang
Shenyang Pharmaceutical University
AnalyteTriterpenoidCytotoxicityPharmacokineticsCytotoxic T cellMass spectrometryAcid hydrolysisChemistryApoptosisGlycosideIn vitroIn vivoCalibration curveG1 phasePhenylpropanoidHeLaFormic acidXanthocerasOleananeNatural productAglyconeHemolysisOrbitraptert-Butyl hydroperoxideTriterpenoid saponinHydrolysateXanthocerasideLeptopus chinensisDoxorubicin Hydrochloride16-deoxybarringtogenol CCell cycleQuantitative structureEdible oilPentacyclic triterpenoidsHealth benefitsAnti tumourOxidative injuryCarbohydrate chainsChromatographyTerpeneBiosynthesisBiochemistryTraditional medicineMAPK/ERK pathwayBotanyCell growthADMEAbsorption (pharmacology)StereochemistryProtein kinase BHuskCell culturePharmacology
8Publications
4H-index
53Citations
Publications 8
Newest
#1Shizhou Qi (SPU: Shenyang Pharmaceutical University)H-Index: 4
#2Xinxin Zhang (SPU: Shenyang Pharmaceutical University)H-Index: 3
Last. Huiyuan Gao (SPU: Shenyang Pharmaceutical University)H-Index: 12
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Abstract Our present and previous phytochemical investigations on Leptopus lolonum have resulted in the isolation of almost 30 phenylpropanoid-conjugated pentacyclic triterpenoids (PCPTs). During the continuous study on PCPTs, this kind of triterpenoid ester is considered as a natural product with low toxicity because of it’s widely distribution in natural plants and edible fruits including kiwi fruit, durian, jujube, pawpaw, apple and pear. In the present work, we report the isolation, structur...
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#1Liping LongH-Index: 3
Last. Huiyuan GaoH-Index: 12
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#1Miao Wang (SPU: Shenyang Pharmaceutical University)H-Index: 9
#2Da Wang (SPU: Shenyang Pharmaceutical University)H-Index: 4
Last. Zhaohua WuH-Index: 2
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: Cassane diterpenoids (CA) are considered as the main active constituents of medicinal plants belonging to the Caesalpinia genus. Three cassane derivatives, bonducellpin G (BG), 7-O-acetyl-bonducellpin C (7-O-AC) and caesalmin E (CE), isolated from Caesalpinia minax Hance seeds, showed strong anti-inflammatory activity. In this paper, pharmacokinetics (BG, 7-O-AC, CE) and tissue distribution (7-O-AC, CE) properties were studied for the first time using a reliable, sensitive and rapid UHPLC-Q-Or...
1 CitationsSource
#1Yiren Yang (SPU: Shenyang Pharmaceutical University)H-Index: 4
#2Liping Long (SPU: Shenyang Pharmaceutical University)H-Index: 3
Last. Luping Sha (SPU: Shenyang Pharmaceutical University)H-Index: 2
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Barrigenol-like triterpenoids (BATs) showed promising anti-tumor, anti-inflammatory and anti-Alzheimer's activities, while, the inhibitory strength was usually affected by their states with aglycones or glycosides. In order to find more BATs as new anti-tumor agents with much more efficiency, the chemical and pharmaceutical studies were carried out on the acid hydrolysate product (AHP) of Semen Aesculi crude extract. Thirteen BATs, including three new aglycones (1–3), two new glycosides (4, 5) a...
1 CitationsSource
#1Xinxin Zhang (SPU: Shenyang Pharmaceutical University)H-Index: 3
#2Song Zhang (SPU: Shenyang Pharmaceutical University)H-Index: 1
Last. Huiyuan Gao (SPU: Shenyang Pharmaceutical University)H-Index: 12
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Abstract Barrigenol-like triterpenoids (BATs), which contain an unusual oleanane substituted by many hydroxyl groups as the skeleton, are subdivided into five subtypes: barrigenol A 1 , barrigenol A 2 , barrigenol R 1 , barringtogenol C, and 16-deoxybarringtogenol C. The variations in acyl derivatives, hydroxyl groups, and carbohydrate chains in their structures have enhanced the diversity of BATs. Moreover, the stable polyhydroxy-replaced pentacyclic skeleton provides an ideal platform for stru...
16 CitationsSource
#1Da Wang (SPU: Shenyang Pharmaceutical University)H-Index: 4
#2Bin Yu (SPU: Shenyang Pharmaceutical University)H-Index: 2
Last. Huiyuan Gao (SPU: Shenyang Pharmaceutical University)H-Index: 12
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AbstractThe Xanthoceras sorbifolia Bunge husks were known for their abundant triterpenoids resource, which contributed to many bioactivities, such as antitumor, antiinflammatory and neuroprotection. The present study has led to the purification of a new triterpenoid saponin, 21β-O-acetyl-xanthohuskiside A (1), together with six known barrigenol derivatives (2–7), whose structures were authenticated on the basis of NMR, HR-MS, IR spectrum and acid hydrolysis experiment. Compound 7 showed more not...
6 CitationsSource
#1Da Wang (SPU: Shenyang Pharmaceutical University)H-Index: 4
#2Dan Su (SPU: Shenyang Pharmaceutical University)H-Index: 7
Last. Xiaobo WangH-Index: 9
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Abstract The high edible oil content of Xanthoceras sorbifolia Bunge seeds contributes to its economic value. In this study, we analysed the barrigenol-like triterpenoids derived from X. sorbifolia husks. We also identified anti-tumour agents that could enhance the health benefits and medicinal value of X. sorbifolia. We isolated 10 barrigenol triterpenoids, including six new compounds (1–6) and four known compounds (7–10). New compounds 3 and 5 showed significant inhibitory activity against the...
12 CitationsSource
#1Da Wang (SPU: Shenyang Pharmaceutical University)H-Index: 4
#2Dan Su (SPU: Shenyang Pharmaceutical University)H-Index: 7
Last. Xiaobo WangH-Index: 9
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Barrigenol-like triterpenoids containing angeloyl residues in their structures are unusual natural products. To discover the chemical constituents responsible for the antitumor activity of Xanthoceras sorbifolia Bunge, the present study was carried out using the husk of this crop. Ten angeloyl barrigenol triterpenoids, including seven new (1–7) and three known compounds (8–10), were isolated from the active fraction via the bioassay-guided method. The structures of the compounds were established...
16 CitationsSource