Hyun-Sung Lee
Baylor College of Medicine
CancerInternal medicineRadiologySurgeryOncologymicroRNACardiothoracic surgeryStage (cooking)Hazard ratioLung cancerSurvival rateEsophagectomyMesotheliomaCarcinomaPneumonectomyEsophageal cancerConfidence intervalCancer researchBioinformaticsMedicineBiologyGastroenterology
91Publications
25H-index
2,474Citations
Publications 77
Newest
#1Hee Jin Jang (BCM: Baylor College of Medicine)H-Index: 16
#2Cynthia Y. Truong (BCM: Baylor College of Medicine)H-Index: 2
Last. R. Taylor Ripley (BCM: Baylor College of Medicine)H-Index: 14
view all 12 authors...
Background null Despite the profound number of malignant pleural mesothelioma (MPM) patients now treated with PD-1 blockade, insight into the underpinnings of rational therapeutic strategies to treat resistance to checkpoint immunotherapy remain unrealized. Our objective was to develop a novel therapeutic approach to overcome primary resistance to PD-1 blockade in MPM. null Methods null We generated a transcriptome signature of resistance to PD-1 blockade in MPM patients treated with nivolumab (...
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#1Nihanth Palivela (BCM: Baylor College of Medicine)H-Index: 3
#2Hyun-Sung Lee (BCM: Baylor College of Medicine)H-Index: 25
Last. Bryan M. Burt (BCM: Baylor College of Medicine)H-Index: 21
view all 7 authors...
ABSTRACT null null Background null Robotic transthoracic first rib resection (R-FRR) has advantages over traditional approaches however its impact on post-operative nTOS outcomes is unknown. Our primary objective was to determine improvement of patient-reported outcome measures (PROMs) of pain and disability following R-FRR in neurogenic thoracic outlet syndrome (nTOS). Our secondary objective was to compare improvement of patient-reported pain between R-FRR and supraclavicular FRR (SC-FRR) in n...
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#1Deborah R. Surman (BCM: Baylor College of Medicine)H-Index: 4
#2Yuan Xu (BCM: Baylor College of Medicine)
Last. Robert T. Ripley (BCM: Baylor College of Medicine)H-Index: 1
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Approximately 20,000 patients per year are diagnosed with esophageal adenocarcinoma (EAC) and malignant pleural mesothelioma (MPM); fewer than 20% survive five years. Effective therapeutic strategies are limited even though patients receive a combination of chemotherapeutics. These tumors harbor thousands of mutations that contribute to tumor development. Downstream of oncogenic driving mutations, altered tumor mitochondria promote resistance to apoptosis. Dynamic Bcl-2 homology-3 profiling (DBP...
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#7R. Taylor Ripley (BCM: Baylor College of Medicine)H-Index: 14
#9Daniel Ying Wang (BCM: Baylor College of Medicine)H-Index: 2
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Interferons (IFNs) are a crucial component in the innate immune response. Especially the IFN-β signaling operates in most cell types and plays a key role in the first line of defense upon pathogen intrusion. The induction of IFN-β should be tightly controlled, because its hyperactivation can lead to tissue damage or autoimmune diseases. Activation of the IFN-β promoter needs Interferon Regulatory Factor 3 (IRF3), together with Nuclear Factor kappa-light-chain-enhancer of activated B cells (NF-κB...
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#1Hyun-Sung Lee (BCM: Baylor College of Medicine)H-Index: 25
#2Masatsugu Hamaji (Kyoto University)H-Index: 10
Last. Bryan M. Burt (BCM: Baylor College of Medicine)H-Index: 21
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Abstract Background The prognostic role of PD-L1 in malignant pleural mesothelioma (MPM) is incompletely understood. Our objectives were to evaluate the evidence for tumor PD-L1 as a prognostic biomarker in MPM through meta-analysis and to determine if tumor PD-L1 expression is associated with survival in MPM patients undergoing macroscopic complete resection. Methods Meta-analysis was performed to determine the association of PD-L1 with overall survival (OS) in MPM (n=1,655) from fourteen studi...
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#1Bryan M. Burt (BCM: Baylor College of Medicine)H-Index: 21
#2Nihanth Palivela (BCM: Baylor College of Medicine)H-Index: 3
Last. Miguel Montero (BCM: Baylor College of Medicine)H-Index: 1
view all 7 authors...
Abstract Objectives Robotic first rib resection (R-FRR) is an emerging approach in the field of thoracic outlet syndrome (TOS) that has technical advantages over traditional open approaches, including superior exposure of the first rib and freedom from retracting neurovascular structures. We set out to define the safety of R-FRR and compare it with that of the conventional supraclavicular approach (SC-FRR). Methods We queried a prospectively maintained, single-surgeon, single-institution databas...
7 CitationsSource
#1Bryan M. Burt (BCM: Baylor College of Medicine)H-Index: 21
#2Hyun-Sung Lee (BCM: Baylor College of Medicine)H-Index: 25
Last. David J. Sugarbaker (BCM: Baylor College of Medicine)H-Index: 101
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Abstract Objective Diffuse chest wall invasion (DCWI) is a common finding in patients undergoing intended resection for malignant pleural mesothelioma (MPM). Our objective was to determine the incidence and preoperative predictors of this finding, and to test our anecdotal impression that contraction of the ipsilateral hemithorax is associated with DCWI. Methods This is a single institution retrospective study of 170 patients undergoing intended macroscopic complete resection (MCR) for MPM from ...
8 CitationsSource
#1Hee Jin Jang (SNU: Seoul National University)H-Index: 16
#2Hyun-Sung Lee (BCM: Baylor College of Medicine)H-Index: 25
Last. Young Tae Kim (SNU: Seoul National University)H-Index: 79
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Abstract Objective We set out to investigate whether transcriptome-based molecular subtypes in lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) are predictive of response to PD-1 blockade. Methods Molecular classification of non-small cell lung cancer (NSCLC) was performed by unsupervised clustering of mRNA sequencing data from 87 LUAD and 101 LUSC specimens, and molecular subtypes were characterized according to their immunogenomic determinants. A prediction algorithm of molec...
8 CitationsSource
#1Wonkyun Ronny ImH-Index: 2
#2Hyun-Sung Lee (BCM: Baylor College of Medicine)H-Index: 25
Last. Yong Sun LeeH-Index: 19
view all 13 authors...
Nc886 is a regulatory non-coding RNA (ncRNA) whose expression is frequently silenced in malignancies. In the case of esophageal squamous cell carcinoma (ESCC), nc886 silencing is associated with shorter survival of patients, suggesting nc886′s tumor suppressor role in ESCC. However, this observation has not been complemented by an in-detail study about nc886′s impact on gene expression and cellular phenotypes. Here we have shown that nc886 inhibits AKT, a key protein in a renowned pro-survival p...
4 CitationsSource