Christiane Gasperi
Technische Universität München
GeneGenome-wide association studyInterleukin 6Internal medicineOncologyMolecular biologyOdds ratioIntrathecalAntibodyHeritabilityGenetic associationHuman leukocyte antigenDNA methylationHaplotypeImmunologyMajor histocompatibility complexT cellB cellDiseaseCerebrospinal fluidAutoimmunityMultiple sclerosisPriming (immunology)Immunoglobulin GClinically isolated syndromePopulationInterferon betaLinkage disequilibriumAmbulatoryGeneticsEpistasisGenetic predispositionMedicineCohortBiologyImmune system
22Publications
10H-index
559Citations
Publications 24
Newest
#1Matthias Bussas (TUM: Technische Universität München)H-Index: 6
#2Sophia Grahl (TUM: Technische Universität München)H-Index: 4
Last. Claus Zimmer (TUM: Technische Universität München)H-Index: 59
view all 12 authors...
Background null Lesions of brain white matter (WM) and atrophy of brain gray matter (GM) are well-established surrogate parameters in multiple sclerosis (MS), but it is unclear how closely these parameters relate to each other. null Objective null To assess across the whole cerebrum whether GM atrophy can be explained by lesions in connecting WM tracts. null Methods null GM images of 600 patients with relapsing-remitting MS (women = 68%; median age = 33.0 years, median expanded disability status...
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#1Michael Hiltensperger (TUM: Technische Universität München)H-Index: 5
#2Eduardo Beltrán (LMU: Ludwig Maximilian University of Munich)H-Index: 9
Last. Kilian Schober (TUM: Technische Universität München)H-Index: 10
view all 30 authors...
Multidimensional single-cell analyses of T cells have fueled the debate about whether there is extensive plasticity or 'mixed' priming of helper T cell subsets in vivo. Here, we developed an experimental framework to probe the idea that the site of priming in the systemic immune compartment is a determinant of helper T cell-induced immunopathology in remote organs. By site-specific in vivo labeling of antigen-specific T cells in inguinal (i) or gut draining mesenteric (m) lymph nodes, we show th...
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#1Christiane Gasperi (TUM: Technische Universität München)H-Index: 10
#2Alexander Hapfelmeier (TUM: Technische Universität München)H-Index: 32
Last. Bernhard Hemmer (TUM: Technische Universität München)H-Index: 88
view all 6 authors...
Objective: To explore the occurrence of diseases and symptoms in the five years prior to diagnosis in patients with multiple sclerosis (MS) in a case-control study. Methods: Using ambulatory claims data we systematically assessed differences in the occurrence of diseases and symptoms in the five years prior to first diagnosis in patients with MS (n=10,262) as compared to patients with two other autoimmune diseases – Crohn’s disease (n=15,502) and psoriasis (n=98,432) - and individuals without th...
3 CitationsSource
#2Jenny Link (KI: Karolinska Institutet)H-Index: 15
#3Dorothea Martin (TUM: Technische Universität München)H-Index: 1
Last. Bernhard Hemmer (TUM: Technische Universität München)H-Index: 88
view all 21 authors...
Upon treatment with biopharmaceuticals, the immune system may produce anti-drug antibodies (ADA) that inhibit the therapy. Up to 40% of multiple sclerosis patients treated with interferon β (IFNβ) develop ADA, for which a genetic predisposition exists. Here, we present a genome-wide association study on ADA and predict the occurrence of antibodies in multiple sclerosis patients treated with different interferon β preparations. We analyzed a large sample of 2757 genotyped and imputed patients fro...
3 CitationsSource
Objective In this observational study, we investigated the impact of genetic factors at the immunoglobulin heavy chain constant locus on chromosome 14 and the major histocompatibility complex region on intrathecal immunoglobulin G, A, and M levels as well as on B cells and plasmablasts in the CSF and blood of patients with multiple sclerosis (MS). Methods Using regression analyses, we tested genetic variants on chromosome 14 and imputed human leukocyte antigen (HLA) alleles for associations with...
2 CitationsSource
#1Till F. M. Andlauer (TUM: Technische Universität München)H-Index: 24
#2Jenny Link (KI: Karolinska Institutet)H-Index: 15
Last. Bernhard Hemmer (TUM: Technische Universität München)H-Index: 88
view all 21 authors...
Background: Upon treatment with biopharmaceuticals, the immune system may produce anti-drug antibodies (ADA) that inhibit the therapy. Up to 40% of multiple sclerosis patients treated with interferon β (IFNβ) develop ADA, for which a genetic predisposition exists. Here, we present a genome-wide association study on ADA and predict the occurrence of antibodies in multiple sclerosis patients treated with different interferon β preparations. Methods: We analyzed a large sample of 2,757 genotyped an...
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#1Mitja MitrovicH-Index: 11
Last. Julia Y MescheriakovaH-Index: 10
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(Cell 175, 1679–1687.e1–e7; November 29, 2018) It has come to our attention that in preparing the final version of this article, the authors inadvertently misspelled the last name of author Charlotte E. Teunissen as “Charlotte E. Theunissen.” This error has been corrected in the article online. In the Editorial Note (Cell 178, 262, June 27, 2019), the editors refer to the original version of the published manuscript. That version contained a misspelled name, and as that has now been corrected, w...
#2Christiane Gasperi (National Association of Statutory Health Insurance Physicians)H-Index: 10
Last. Bernhard Hemmer (National Association of Statutory Health Insurance Physicians)H-Index: 88
view all 4 authors...
Objective To investigate the hypothesis that vaccination is a risk factor for multiple sclerosis (MS) by use of German ambulatory claims data in a case-control study. Methods Using the ambulatory claims data of the Bavarian Association of Statutory Health Insurance Physicians covering 2005–2017, logistic regression models were used to assess the relation between MS (n = 12,262) and vaccinations in the 5 years before first diagnosis. Participants newly diagnosed with Crohn disease (n = 19,296) or...
18 CitationsSource
Objective To identify CSF parameters at diagnosis of clinically isolated syndrome (CIS) and MS that are associated with early inflammatory disease activity as measured by standardized cerebral MRI (cMRI). Methods One hundred forty-nine patients with newly diagnosed CIS and MS were included in the retrospective study. cMRI at onset and after 12 months was analyzed for T2 and gadolinium-enhancing lesions. CSF was tested for oligoclonal bands and intrathecal synthesis of immunoglobulin G (IgG), A (...
6 CitationsSource
#1Christiane Gasperi (TUM: Technische Universität München)H-Index: 10
#2Anke Salmen (University of Bern)H-Index: 14
Last. Bernhard Hemmer (TUM: Technische Universität München)H-Index: 88
view all 21 authors...
Importance Reliable biomarkers associated with disability worsening in multiple sclerosis (MS) are still needed. Objective To determine a possible association of intrathecal IgG synthesis and early disability worsening as measured by Expanded Disability Status Scale (EDSS) scoring in patients with relapsing-remitting MS or clinically isolated syndrome. Design, Setting, and Participants Cerebrospinal fluid measurements and clinical data from the observational longitudinal German national multiple...
20 CitationsSource