Janusz Dembowski
Wrocław Medical University
CancerInternal medicineUrologyGenotypeSurgeryPathologyOncologyRetrospective cohort studyAlleleStage (cooking)Physical therapyProspective cohort studyHaplotypeImmunologyCystectomyRenal cell carcinomaElectromyographyCarcinomaPyeloplastyImmunotherapyUrinary incontinencePregnancyUrineLaparoscopyProstate cancerNephrectomyBladder cancerPelvic floorTransplantationIn patientCancer researchMedicineUrinary systemBiologyGastroenterology
49Publications
11H-index
256Citations
Publications 50
Newest
#1Beata SzymańskaH-Index: 4
Last. Agnieszka PiwowarH-Index: 21
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#1Wojciech Krajewski (Wrocław Medical University)H-Index: 12
#2Łukasz Nowak (Wrocław Medical University)H-Index: 3
Last. Romuald Zdrojowy (Wrocław Medical University)H-Index: 14
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Background: Cisplatin-based neoadjuvant chemotherapy (NAC) followed by radical cystectomy (RC) with pelvic lymph-node dissection is the standard treatment for cT2-4a cN0 cM0 muscle-invasive bladder cancer (MIBC). Despite the significant improvement of primary-tumor downstaging with NAC, up to 50% of patients are eventually found to have advanced residual disease (pT3–T4 and/or histopathologically confirmed nodal metastases (pN+)) at RC. Currently, there is no established standard of care in such...
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#1Beata Szymańska (Wrocław Medical University)H-Index: 4
#2Ewa Sawicka (Wrocław Medical University)H-Index: 8
Last. Agnieszka Piwowar (Wrocław Medical University)H-Index: 21
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During the last decade, a significant increase in the incidence of bladder cancer (BC) has been observed. Angiogenesis plays a key role in the process of tumor growth and metastasis. Additionally, the participation of oxidative stress and chronic inflammation in BC pathogenesis is indicated. The aim of the study was to evaluate the urinary levels of parameters of angiogenesis, stimulating angiogenin (ANG) and inhibiting angiostatin (ANGST), 8-iso-prostaglandin F2α (8-iso-PGF2α) as a marker of ox...
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Introduction: Bladder cancer is one of the most common malignancies worldwide. Aim: To analyse the influence of restaging transurethral resection of bladder tumour (reTURB) on outcomes in patients treated with BCG immunotherapy. Material and methods: We analysed a database of 491 patients who were treated in a Bacillus Calmette-Guerin (BCG) outpatient department between 1998 and 2016. A minimum of 12 months of follow-up was required. The study included 235 patients with a history of the reTURB p...
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#1Wojciech Krajewski (Wrocław Medical University)H-Index: 12
#2Romuald Zdrojowy (Wrocław Medical University)H-Index: 14
Last. Anna Kołodziej (Wrocław Medical University)H-Index: 11
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Introduction: The study aimed to analyze the influence of restaging transurethral resection of bladder tumor (reTURB) timing on outcomes in patients receiving Bacillus Calmette-Guerin (BCG) immunotherapy. Material and Methods: This retrospective study enrolled 491 patients with bladder cancer receiving BCG intravesical therapy between 1998 and 2016. All patients were followed up for at least 12 months and received at least 7 BCG instillations. The patients were analyzed in terms of recurrence fr...
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#1Michał Matuszewski (Wrocław Medical University)H-Index: 5
#2Beata Szymańska (Wrocław Medical University)H-Index: 4
Last. Agnieszka Piwowar (Wrocław Medical University)H-Index: 21
view all 6 authors...
Background. Urothelial carcinoma is the most common type of bladder cancer (BC). It makes up more than 90% of all bladder cancers. Uroplakins are tissue-specific, glycoproteins, playing a role in the construction and function of urothelium. The emergence of uroplakins in the urine and/or plasma may be of potential importance in the early detection of BC. In our study, the diagnostic value of plasma and urine uroplakin 2 (UP2) concentration in bladder cancer was investigated, with an assessment o...
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#1Zofia Marchewka (Wrocław Medical University)H-Index: 10
#2Beata Szymańska (Wrocław Medical University)H-Index: 4
Last. Agnieszka Piwowar (Wrocław Medical University)H-Index: 21
view all 5 authors...
Introduction A steady increase in cases of bladder cancer (BC) has been observed. Detection of unfavorable changes, especially in the early stages of disease, is crucial to medical procedure. There is still a need to search for new, non-invasive biomarkers of BC. The aim of this study was to estimate the levels of selected low molecular weight proteins (LMWP) and enzymes in the urine of patients at different BC stages and grades.
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#1Beata Szymańska (Wrocław Medical University)H-Index: 4
#2Michał Matuszewski (Wrocław Medical University)H-Index: 5
Last. Anna Długosz (Wrocław Medical University)H-Index: 10
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Background. Uroplakins are glycoproteins investigated as potential markers of urothelial carcinoma. However, their role in chemical carcinogenesis is uncertain. In this study the diagnostic value of plasma and urine uroplakin IIIa (UPIIIa) levels in bladder cancer (BC) was investigated, particularly in the aspect of environmental exposure to chemical carcinogens, measured by DNA damage and detoxification ability in the BC smoking group. The correlation between uroplakin, 8-OHdG, and GSTπ was inv...
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#1Mateusz Dzięgała (Wrocław Medical University)H-Index: 4
#2Wojciech Krajewski (Wrocław Medical University)H-Index: 12
Last. Romuald Zdrojowy (Wrocław Medical University)H-Index: 14
view all 5 authors...
Introduction Extracorporeal shock wave lithotripsy (ESWL) is one of the most useful methods available for the treatment of urolithiasis. However, despite its significant benefits, adverse effects can occur. Oxidative stress mediated by ischemia-reperfusion might contribute to kidney injury after ESWL. Moreover, an acute kidney injury (AKI) may develop. AKI is typically diagnosed by measuring serum creatinine level, yet serum creatinine does not allow for early detection of sub-clinical AKI. The ...
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#1Wojciech Krajewski (Wrocław Medical University)H-Index: 12
#2Joanna Wojciechowska (Wrocław Medical University)H-Index: 5
Last. Tomasz SzydełkoH-Index: 9
view all 5 authors...
: Ureteropelvic junction obstruction (UPJO) causes a reduction in the urine flow from the renal pelvis into the ureter. Untreated UPJO may cause hydronephrosis, chronic infection or urolithiasis and will often result in progressive deterioration of renal function. Most cases of UPJO are congenital; however, the disease can be clinically silent until adulthood. Other causes, both intrinsic and extrinsic, are acquired and include urolithiasis, post-operative/inflammatory/ischemic stricture, fibroe...
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