G. Bruno
Sapienza University of Rome
Internal medicineFecal bacteriotherapyPediatricsProspective cohort studyImmunologyBreath testHelicobacter pyloriEnemaDiseaseCrohn's diseaseMalabsorptionUlcerative colitisGastrointestinal tractPopulationGastric emptying timeMucosal healingHost responseClostridium difficileIn patientGut floraMedicineBiologyMicrobiologyGastroenterology
44Publications
12H-index
433Citations
Publications 46
Newest
#1Alfonso Piciocchi (ISS: Istituto Superiore di Sanità)
#2Elena A.P. Germinario (ISS: Istituto Superiore di Sanità)H-Index: 11
Last. Fabio Accarpio (Sapienza University of Rome)H-Index: 10
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Colorectal cancer (CRC) is a leading cause of cancer death worldwide, and its incidence is correlated with infections, chronic inflammation, diet, and genetic factors. An emerging aspect is that microbial dysbiosis and chronic infections triggered by certain bacteria can be risk factors for tumor progression. Recent data suggest that certain bacterial toxins implicated in DNA attack or in proliferation, replication, and death can be risk factors for insurgence and progression of CRC. In this stu...
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#1Francesca Aprile (Sapienza University of Rome)H-Index: 2
#2G. Bruno (Sapienza University of Rome)H-Index: 12
Last. Stefano Pontone (Sapienza University of Rome)H-Index: 13
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Gut microbiota plays an important role in human health. It may promote carcinogenesis and is related to several diseases of the gastrointestinal tract. This study of microbial dysbiosis in the etiology of colorectal adenoma aimed to investigate the possible causative role of microbiota in the adenoma-carcinoma sequence and its possible preventive role. A systematic, PRISMA-guided review was performed. The PubMed database was searched using "adenoma microbiota" and selecting original articles bet...
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#1G. BrunoH-Index: 12
Last. Carola SeveriH-Index: 24
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#1Piera ZaccariH-Index: 3
#2E. RibichiniH-Index: 1
Last. Carola SeveriH-Index: 24
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#2Alessandra OlivaH-Index: 23
Last. Carola SeveriH-Index: 24
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The aim of this study was to evaluate the secondary resistance in Helicobacter pylori (Hp) infected patients who had failed a first-line therapy, and to compare the genotypic tests performed directly on gastric samples with phenotypic tests performed on culture media. The eradication rate of patients treated with bismuth quadruple therapy (BQT) is also evaluated. A total of 80 positive specimens were retrospectively examined. Antibiotic susceptibility testing of Hp strains was performed by E-tes...
4 CitationsSource
#1Alessandra Oliva (Sapienza University of Rome)H-Index: 23
#2Lucia Aversano (Sapienza University of Rome)H-Index: 1
Last. Vincenzo Vullo (Sapienza University of Rome)H-Index: 53
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Background: Clostridioides difficile infection (CDI) might be complicated by the development of nosocomial bloodstream infection (n-BSI). Based on the hypothesis that alteration of the normal gut integrity is present during CDI, we evaluated markers of microbial translocation, inflammation, and intestinal damage in patients with CDI. Methods: Patients with documented CDI were enrolled in the study. For each subject, plasma samples were collected at T0 and T1 (before and after CDI therapy, respec...
4 CitationsSource
#1G. Bruno (Sapienza University of Rome)H-Index: 12
#2Antonella Gagliardi (Sapienza University of Rome)H-Index: 8
Last. Serena SchippaH-Index: 26
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: This short communication reports the preliminary results of Fecal Microbial Transplantation (FMT) impact on microbiota, microbial translocation (MT), and immune activation in four recurrent Clostridium difficile infection (R-CDI) patients. After FMT a restore of gut microbiota composition with a significant increase of fecal acetyl-putrescine and spermidine and fecal acetate and butyrate, a decrease of immune activation of T cells CD4+ and CD8+levels, and of LPS binding protein (LBP) level, we...
5 Citations
#1Emanuela Ribichini (Sapienza University of Rome)H-Index: 1
#1E. Ribichini (Sapienza University of Rome)H-Index: 1
Last. Carola Severi (Sapienza University of Rome)H-Index: 24
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The role of fibre intake in the management of patients with pancreatic disease is still controversial. In acute pancreatitis, a prebiotic enriched diet is associated with low rates of pancreatic necrosis infection, hospital stay, systemic inflammatory response syndrome and multiorgan failure. This protective effect seems to be connected with the ability of fibre to stabilise the disturbed intestinal barrier homeostasis and to reduce the infection rate. On the other hand, in patients with exocrin...
3 CitationsSource
#1G. Bruno (Sapienza University of Rome)H-Index: 12
#2Piera Zaccari (Sapienza University of Rome)H-Index: 3
Last. Carola Severi (Sapienza University of Rome)H-Index: 24
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: Proton pump inhibitors (PPIs) are common medications within the practice of gastroenterology. These drugs, which act through the irreversible inhibition of the hydrogen/potassium pump (H+/K+-ATPase pump) in the gastric parietal cells, are used in the treatment of several acid-related disorders. PPIs are generally well tolerated but, through the long-term reduction of gastric acid secretion, can increase the risk of an imbalance in gut microbiota composition (i.e., dysbiosis). The gut microbiot...
45 CitationsSource