Madoka Fujisawa
University of Tokyo
PathophysiologyGeneEpidemiologyComplement systemInternal medicineGenotypePathologyMagnetic resonance imagingFactor HRecombinationAntibodyAutoantibodyCardiologyMortality rateImmunologyFibrin degradation productSkin ulcerFibrinolysisCongenital cytomegalovirus infectionPosterior reversible encephalopathy syndromeAtypical hemolytic uremic syndromePerforation (oil well)Thrombotic microangiopathyEculizumabPartial thromboplastin timeKidney diseaseDisseminated intravascular coagulationPolyarthritisAntithrombinFibrinogenMEDLINECongenital disorderEnteritisGlomerulopathyImmunosuppressionGastrointestinal perforationThrombosisPathogenesisAbdominal painComplement (complexity)Genomic Structural VariationIn patientBrain edemaGene clusterInfectious disease (medical specialty)GeneticsNephrologyAnti-SSA/Ro autoantibodiesComputational biologyMedicineCohortMicrobiologyPlateletGastroenterology
9Publications
3H-index
28Citations
Publications 9
Newest
#1Madoka Fujisawa (UTokyo: University of Tokyo)H-Index: 3
#2Atsushi Yasumoto (UTokyo: University of Tokyo)H-Index: 14
Last. Masaomi Nangaku (UTokyo: University of Tokyo)H-Index: 84
view all 7 authors...
Atypical haemolytic uremic syndrome (aHUS) is associated with complement system abnormality, such as production of complement factor H (CFH) autoantibodies. The growing evidence indicates complement overactivation on platelets is intimately involved in aHUS pathogenesis, besides endothelial injury. We here showed plasma from patients with anti-CFH antibodies induced aggregation of washed platelets, while purified anti-CFH antibodies suppressed aggregation. This suggested anti-CFH antibody itself...
Source
#1Satoko Sakurai (UTokyo: University of Tokyo)H-Index: 3
#2Hideki Kato (UTokyo: University of Tokyo)H-Index: 24
Last. Masaomi Nangaku (UTokyo: University of Tokyo)H-Index: 84
view all 10 authors...
AIM: Atypical hemolytic uremic syndrome (aHUS), characterized by thrombotic microangiopathy (TMA), is a genetic, life-threatening disease which needs many differential diagnoses. This study aimed to reveal coagulation and fibrinolysis profiles in aHUS and secondary TMA patients. Furthermore, we investigated whether aHUS patients progress to, and meet, disseminated intravascular coagulation (DIC) criteria. METHODS: The acute phase samples were available in 15 aHUS and 20 secondary TMA patients. W...
Source
#1Yuka Sugawara (UTokyo: University of Tokyo)H-Index: 2
#2Hideki Kato (UTokyo: University of Tokyo)H-Index: 24
Last. Masaomi Nangaku (UTokyo: University of Tokyo)H-Index: 84
view all 10 authors...
Source
#1Madoka Fujisawa (UTokyo: University of Tokyo)H-Index: 3
#2Hideki Kato (UTokyo: University of Tokyo)H-Index: 24
Last. Masaomi Nangaku (UTokyo: University of Tokyo)H-Index: 84
view all 13 authors...
Source
#1Yuka SugawaraH-Index: 2
#2Hideki KatoH-Index: 24
Last. Masaomi NangakuH-Index: 84
view all 7 authors...
Source
#1Madoka Fujisawa (UTokyo: University of Tokyo)H-Index: 3
#2Hideki Kato (UTokyo: University of Tokyo)H-Index: 24
Last. Masaomi Nangaku (UTokyo: University of Tokyo)H-Index: 84
view all 13 authors...
Background Atypical hemolytic uremic syndrome (aHUS) is caused by complement overactivation, and its presentation and prognosis differ according to the underlying molecular defects. The aim of this study was to characterize the genetic backgrounds of aHUS patients in Japan and to elucidate the associations between their genetic backgrounds, clinical findings, and outcomes.
Source
#1Kahori Nasu (UTokyo: University of Tokyo)H-Index: 2
#2Madoka Fujisawa (UTokyo: University of Tokyo)H-Index: 3
Last. Masaomi Nangaku (UTokyo: University of Tokyo)H-Index: 84
view all 4 authors...
: Posterior reversible encephalopathy syndrome (PRES) is a clinical and radiological condition with diverse neurological manifestations. Many clinical factors are known causes of PRES, but only a few cases of PRES have been reported in patients with chronic kidney disease (CKD) and infectious disease. We describe three cases of PRES in patients with CKD triggered by various infectious diseases. Characteristic hyperintense signals on magnetic resonance imaging (MRI) indicating reversible vasogeni...
Source
#1Yoko Yoshida (UTokyo: University of Tokyo)H-Index: 16
#2Hideki Kato (UTokyo: University of Tokyo)H-Index: 24
Last. Masaomi Nangaku (UTokyo: University of Tokyo)H-Index: 84
view all 9 authors...
Source
#1Yuichi Tachikawa (UTokyo: University of Tokyo)H-Index: 1
#2Hiroaki Nozawa (UTokyo: University of Tokyo)H-Index: 22
Last. Toshiaki Watanabe (UTokyo: University of Tokyo)H-Index: 71
view all 19 authors...
Abstract Introduction Cytomegalovirus (CMV) infection of the gastrointestinal tract is an uncommon illness, but can be observed in immunocompromised patients. Systemic lupus erythematosus (SLE) patients are generally at high risk of CMV infection. Here we report a subacute progressive case of colitis in SLE accompanied by cytomegalovirus infection. Presentation of case The patient, a 79-year-old woman, was hospitalized complaining of fever, polyarthritis, and skin ulcer that had lasted seven day...
Source
This website uses cookies.
We use cookies to improve your online experience. By continuing to use our website we assume you agree to the placement of these cookies.
To learn more, you can find in our Privacy Policy.