Prachi Tewari
Academy of Scientific and Innovative Research
Environmental chemistryCyclin DHaCaTInternal medicineDownregulation and upregulationEndocrinologyFunction (biology)AntigenMolecular biologyCyclin AReceptorKinaseChemistryAcquired immune systemCell surface receptorImmunologySystemic administrationSuperoxide dismutaseTLR4Oxidative stressSystemic inflammationBALB/cEpidemic dropsyInflammationLymphocyteTumor initiationCytokineMixed lymphocyte reactionBenzanthroneSpleenPopulationReactive oxygen speciesp38 mitogen-activated protein kinasesNitric oxidePollutantBiologyImmune systemCyclin ECell biologyPharmacology
9Publications
3H-index
44Citations
Publications 6
Newest
#1Prachi Tewari (IITR: Indian Institute of Toxicology Research)H-Index: 3
#2Ruchi Roy (IITR: Indian Institute of Toxicology Research)H-Index: 12
Last. Mukul Das (IITR: Indian Institute of Toxicology Research)H-Index: 33
view all 10 authors...
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#1Prachi Tewari (IITR: Indian Institute of Toxicology Research)H-Index: 3
#2Payal Mandal (IITR: Indian Institute of Toxicology Research)H-Index: 5
Last. Anurag Tripathi (IITR: Indian Institute of Toxicology Research)H-Index: 22
view all 7 authors...
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#1Payal Mandal (IITR: Indian Institute of Toxicology Research)H-Index: 5
#2Prachi Tewari (IITR: Indian Institute of Toxicology Research)H-Index: 3
Last. Anurag Tripathi (IITR: Indian Institute of Toxicology Research)H-Index: 22
view all 8 authors...
Abstract Consumption of edible oils contaminated with Argemone oil (AO) leads to a clinical condition called “Epidemic dropsy”. Earlier studies have reported that metabolism and oxidative stress primarily contributes to AO toxicity, however, the involvement of immune system has not been assessed so far. Therefore, the present study was undertaken to systematically assess the effect of AO exposure on the function of immune system in Balb/c mice. The repeated exposure of AO for 28 days caused prom...
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#1Prachi Tewari (AcSIR: Academy of Scientific and Innovative Research)H-Index: 3
#1Prachi Tewari (AcSIR: Academy of Scientific and Innovative Research)H-Index: 1
Last. Anurag Tripathi (IITR: Indian Institute of Toxicology Research)H-Index: 22
view all 7 authors...
Abstract Our prior studies have reported that Benzanthrone (BA) manifests inflammatory responses in the spleen of Balb/c mice. The present investigation was carried out to study the impact of BA on macrophages, which are the primary scavenger cells in the body that act as a connecting link between innate and adaptive immunity. Parenteral administration of BA (daily for one week) to mice resulted in enhanced levels of nitric oxide (NO) and overexpression of inflammatory markers (COX-2, MMP-9 and ...
5 CitationsSource
#1Sakshi Mishra (IITR: Indian Institute of Toxicology Research)H-Index: 11
#2Prachi Tewari (IITR: Indian Institute of Toxicology Research)H-Index: 3
Last. Mukul Das (IITR: Indian Institute of Toxicology Research)H-Index: 33
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Among food contaminants, mycotoxins are toxic to both human and animal health. Our prior studies suggest that Deoxynivalenol (DON), a mycotoxin, behaves as a tumor promoter by inducing edema, hyperplasia, ODC activity and activation of MAPK's in mouse skin. In this study, topical application of DON, 336 and 672 nmol significantly enhanced ROS levels, DNA damage and apoptosis with concomitant downregulation of Ki-67, cyclin D, cyclin E, cyclin A and cyclin-dependent kinases (CDK4 and CDK2) thereb...
15 CitationsSource
#1Prachi Tewari (IITR: Indian Institute of Toxicology Research)H-Index: 3
#2Ruchi Roy (IITR: Indian Institute of Toxicology Research)H-Index: 12
Last. Mukul Das (IITR: Indian Institute of Toxicology Research)H-Index: 33
view all 10 authors...
Abstract Benzanthrone (BA) is an important dye intermediate which is used in the manufacturing of several polycyclic vat and disperse dyes in textile industries. Several studies have indicated that the general population is also exposed to BA owing to its release from furnace effluents and automobile exhausts in the environment. In several clinical studies, it has been shown that workers exposed to BA developed itching, burning sensation, erythema and hyperpigmentation of the skin, which could b...
12 CitationsSource