Yunxia Luo
Guangzhou University of Chinese Medicine
Statistical classificationMachine learningSupport vector machineArtificial intelligenceMatthews correlation coefficientDECIPHERMolecular descriptorRandom forestNeuroscienceTest setTraditional Chinese medicineCholinergicMedical prescriptionNeuroprotectionIn silicoOxidative stressAmyloid betaLiver injuryInflammationNeurodegenerationHyperphosphorylationTau proteinPeroxynitriteDiseaseSystems pharmacologyStriatumReperfusion injurySuperoxideBiological networkBushen yizhiDanggui-shaoyao-sanConsensus modelDrug targetFilter analysisLiver damageMolecular mechanismNeuronal apoptosisMultilevel dataPotential mechanismComputer sciencePredictive modellingStrokeNaive Bayes classifierIschemiaBioinformaticsADMEComputational biologyMedicineIdentification (information)BiologyNeuroinflammationMechanism (biology)Pharmacology
7Publications
4H-index
71Citations
Publications 7
Newest
#1Yunxia LuoH-Index: 4
#2Hansen Chen (Li Ka Shing Faculty of Medicine, University of Hong Kong)H-Index: 14
Last. Jiangang ShenH-Index: 50
view all 5 authors...
Danggui-Shayao-San (DSS) is a famous Traditional Chinese Medicine formula that used for treating pain disorders and maintaining neurological health. Recent studies indicate that DSS has neuroprotective effects against ischemic brain damage but its underlining mechanisms remain unclear. Herein, we investigated the neuroprotective mechanisms of DSS for treating ischemic stroke. Adult male Sprague-Dawley (S.D.) rats were subjected to 2 h of middle cerebral artery occlusion (MCAO) plus 22 h of reper...
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#1Yunxia Luo (Guangzhou University of Chinese Medicine)H-Index: 4
#2Dongli Li (Guangzhou University of Chinese Medicine)H-Index: 4
Last. Shuhuan Fang (Guangzhou University of Chinese Medicine)H-Index: 14
view all 13 authors...
Alzheimer's disease (AD) is a complex neurodegenerative disease characterized by cognitive dysfunction. Kai-Xin-San (KXS) is a traditional Chinese medicine (TCM) formula that has been used to treat AD patients for over a thousand years in China. However, the therapeutic mechanisms of KXS for treating AD have not been fully explored. Herein, we used a comprehensive network pharmacology approach to investigate the mechanism of action of KXS in the treatment of AD. This approach consists of constru...
2 CitationsSource
#1Qihui Wu (Guangzhou University of Chinese Medicine)H-Index: 5
#2Chuipu Cai (Guangzhou University of Chinese Medicine)H-Index: 7
Last. Jiansong Fang (Guangzhou University of Chinese Medicine)H-Index: 20
view all 12 authors...
Backgrounds and Aims: Recently, a growing number of hepatotoxicity cases aroused by Traditional Chinese Medicine (TCM) have been reported, causing increasing concern. To date, the reported predictive models for drug induced liver injury show low prediction accuracy and there are still no related reports for hepatotoxicity evaluation of TCM systematically. Additionally, the mechanism of herb induced liver injury (HILI) still remains unknown. The aim of the study was to identify potential hepatoto...
6 CitationsSource
#1Yunxia Luo (Guangzhou University of Chinese Medicine)H-Index: 4
#2Xin-Yue Wang (SYSU: Sun Yat-sen University)H-Index: 4
Last. Jiansong Fang (Guangzhou University of Chinese Medicine)H-Index: 20
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Abstract Liver injury remains a significant global health problem and has a variety of causes, including oxidative stress (OS), inflammation, and apoptosis of liver cells. There is currently no curative therapy for this disorder. Sanwei Ganjiang Prescription (SWGJP), derived from traditional Chinese medicine (TCM), has shown its effectiveness in long-term liver damage therapy, although the underlying molecular mechanisms are still not fully understood. To explore the underlining mechanisms of ac...
1 CitationsSource
#1Haobin Cai (Guangzhou University of Chinese Medicine)H-Index: 5
#2Yunxia Luo (Guangzhou University of Chinese Medicine)H-Index: 4
Last. Jun Xu (SYSU: Sun Yat-sen University)H-Index: 27
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Bushen-Yizhi prescription (BSYZ) has been an effective traditional Chinese medicine (TCM) prescription in treating Alzheimer’s disease (AD) for hundreds of years. However, the underlying mechanisms have not been fully elucidated yet. In this work, a systems pharmacology approach was developed to reveal the underlying molecular mechanisms of BSYZ in treating AD. First, we obtained 329 candidate compounds of BSYZ by in silico ADME/T filter analysis and 138 AD-related targets were predicted by our ...
19 CitationsSource
#1Chuipu Cai (Guangzhou University of Chinese Medicine)H-Index: 7
#2Qihui Wu (Guangzhou University of Chinese Medicine)H-Index: 5
Last. Qi Wang (Guangzhou University of Chinese Medicine)H-Index: 24
view all 10 authors...
ROCK II is an important pharmacological target linked to central nervous system disorders such as Alzheimer’s disease. The purpose of this research is to generate ROCK II inhibitor prediction models by machine learning approaches. Firstly, four sets of descriptors were calculated with MOE 2010 and PaDEL-Descriptor, and optimized by F-score and linear forward selection methods. In addition, four classification algorithms were used to initially build 16 classifiers with k-nearest neighbors $$(k\hb...
9 CitationsSource
#1Yunxia Luo (Guangzhou University of Chinese Medicine)H-Index: 4
#2Qi Wang (Guangzhou University of Chinese Medicine)H-Index: 24
Last. Yongbin Zhang (Guangzhou University of Chinese Medicine)H-Index: 7
view all 3 authors...
Abstract Ethnopharmacological relevance Neurodegenerative diseases (NDs) is a time-dependent course for a sequence of conditions that primarily impact the neurons in the human brain, ultimately, resulting in persistence and progressive degeneration and / or death of nerve cells and reduction of cognition and memory function. Currently, there are no therapeutic approaches to cure neurodegeneration, except certain medicines that temporarily alleviate symptoms, facilitating the improvement of a pat...
32 CitationsSource