Yoshiro Itatani
Kyoto University
Mouse model of colorectal and intestinal cancerCancerInternal medicineRadiologyChemokineSurgeryPathologyOncologyNotch signaling pathwayImmunohistochemistryTumor microenvironmentChemotherapyMetastasis suppressorMetastasisTumor progressionMyeloidBone marrowLaparoscopyAngiogenesisLymphadenectomyKRASMetastasis Suppressor GeneCell cycleCancer researchColorectal cancerMedicineCCL15AnastomosisBiologyCancer cell
46Publications
16H-index
905Citations
Publications 41
Newest
#1Takehito Yamamoto (Kyoto University)H-Index: 6
#2Kenji Kawada (Kyoto University)H-Index: 27
Last. Yoshiharu Sakai (Kyoto University)H-Index: 60
view all 9 authors...
Although numerous studies have highlighted the prognostic values of various inflammation-related markers, clinical significance remains to be elucidated. The prognostic values of inflammation-related biomarkers for rectal cancer were investigated in this study. A total of 448 patients with stage II/III rectal cancer undergoing curative resection were enrolled from the discovery cohort (n = 240) and validation cohort (n = 208). We comprehensively compared the prognostic values of 11 inflammation-...
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#1Yoshiro Itatani (UCSD: University of California, San Diego)H-Index: 16
#2Takamasa Yamamoto (UCSD: University of California, San Diego)H-Index: 5
Last. Napoleone Ferrara (UCSD: University of California, San Diego)H-Index: 179
view all 8 authors...
We tested cis-ApcΔ716/Smad4+/− and cis-ApcΔ716/Smad4+/−KrasG12D mice, which recapitulate key genetic abnormalities accumulating during colorectal cancer (CRC) tumorigenesis in humans, for responsiveness to anti-VEGF therapy. We found that even tumors in cis-ApcΔ716/Smad4+/−KrasG12D mice, although highly aggressive, were suppressed by anti-VEGF treatment. We tested the hypothesis that inflammation, a major risk factor and trigger for CRC, may affect responsiveness to anti-VEGF. Chemically induced...
2 CitationsSource
#1Yoshiyuki Kiyasu (Kyoto University)H-Index: 5
#2Kenji Kawada (Kyoto University)H-Index: 27
Last. Yoshiharu Sakai (Kyoto University)H-Index: 60
view all 13 authors...
Abstract Tumor-stromal interaction is implicated in tumor progression. Although CCR1 expression in myeloid cells could be associated with pro-tumor activity, it remains elusive whether disruption of CCR1-mediated myeloid cell accumulation can suppress tumor progression. Here, we investigated the role of CCR1 depletion in myeloid cells in two syngeneic colorectal cancer mouse models: MC38, a transplanted tumor model and CMT93, a liver metastasis model. Both cells induced tumor accumulation of CCR...
1 CitationsSource
#1Yoshiro ItataniH-Index: 16
#2Takamasa YamamotoH-Index: 5
Last. Napoleone FerraraH-Index: 179
view all 3 authors...
Source
#1Yoshiro Itatani (Kyoto University)H-Index: 16
#2Kenji Kawada (Kyoto University)H-Index: 27
Last. Yoshiharu Sakai (Kyoto University)H-Index: 60
view all 9 authors...
Laparoscopic approaches have become a standard strategy for colon cancer patients who undergo surgical treatment. Complete mesocolic excision (CME) with central vascular ligation (CVL) is the fundamental principle of radical resection of colon cancers. Splenic flexure colon cancer (SFCC) is rare, accounting for less than 4% of all colorectal cancer cases. Moreover, a laparoscopic approach for SFCC following the CME/CVL concept can be challenging because the blood supply of the splenic flexure is...
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#1Tomoaki Okada (Kyoto University)H-Index: 4
#2Kenji Kawada (Kyoto University)H-Index: 27
Last. Yoshiharu Sakai (Kyoto University)H-Index: 60
view all 7 authors...
BACKGROUND: Stereotactic navigation enables surgeons to use the preoperative CT or MRI images as a real-time "navigation map." Although stereotactic navigation has been established in neurosurgery and orthopedic surgery, whether this technology is applicable to GI tract surgery remains challenging because of tissue deformation and organ motion. A critical component of this technology is the registration that links the patient's actual body to the preoperative imaging data. OBJECTIVE: The objecti...
1 CitationsSource
#1Takehito Yamamoto (Kyoto University)H-Index: 6
#2Kenji Kawada (Kyoto University)H-Index: 27
Last. Yoshiharu Sakai (Kyoto University)H-Index: 60
view all 7 authors...
BACKGROUND: Technical difficulties in rectal surgery are often related to dissection in a limited surgical field. This study investigated the clinical value of MRI pelvimetry in the prediction of surgical difficulty associated with minimally invasive rectal surgery. METHODS: Patients with rectal cancer who underwent laparoscopic or robotic total mesorectal excision between 2005 and 2017 were reviewed retrospectively and categorized according to surgical difficulty on the basis of duration of sur...
1 CitationsSource
#1Aya Nishiuchi (Kyoto University)H-Index: 2
#2Shigeo Hisamori (Kyoto University)H-Index: 17
Last. Yoshiharu SakaiH-Index: 60
view all 15 authors...
A lack of caudal-type homeobox transcription factor 2 (CDX2) protein expression has been proposed as a prognostic biomarker for colorectal cancer (CRC). However, the relationship between CDX2 levels and the survival of patients with stage II/III CRC along with the relationship between microRNAs (miRs) and CDX2 expression are unclear. Tissue samples were collected from patients with stage II/III CRC surgically treated at Kyoto University Hospital. CDX2 expression was semi-quantitatively evaluated...
4 CitationsSource
#1Yoshiro Itatani (Kyoto University)H-Index: 16
#2Kenji Kawada (Kyoto University)H-Index: 27
Last. Yoshiharu Sakai (Kyoto University)H-Index: 60
view all 3 authors...
Transforming growth factor-beta (TGF-β) signaling is one of the important cellular pathways that play key roles for tissue maintenance. In particular, it is important in the context of inflammation and tumorigenesis by modulating cell growth, differentiation, apoptosis, and homeostasis. TGF-β receptor type 2 (TGFBR2) mutations affected by a mismatch repair deficiency causes colorectal cancers (CRCs) with microsatellite instability, which is, however, associated with relatively better survival ra...
23 CitationsSource
#1Yoshiro Itatani (Kyoto University)H-Index: 16
#2Tomoaki Okada (Kyoto University)H-Index: 4
Last. Yoshiharu Sakai (Kyoto University)H-Index: 60
view all 9 authors...
Background Internal hemorrhoids are the most common anal diseases. Aluminum potassium sulfate and tannic acid (ALTA) injection is a new sclerosing therapy for the treatment of internal hemorrhoids. Although ALTA injection has been widely used, there are no previous reports of rectal cancer patients who underwent robot-assisted low anterior resection (Rob-LAR) after ALTA injection to treat internal hemorrhoids.
1 CitationsSource