Dan J. Raz
City of Hope National Medical Center
Quality of lifeCancerInternal medicineSurgeryOncologyGene knockdownIntensive care medicineChemistryPhysical therapyLung cancerLung cancer screeningCisplatinEsophageal cancerIntervention (counseling)TriptolideCancer researchFamily medicineMedicineBiologyCancer cell
95Publications
17H-index
992Citations
Publications 97
Newest
#2Theresa A. RenoH-Index: 7
Last. Dan J. RazH-Index: 17
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The Wnt pathway is a developmental pathway that is abnormally upregulated in cancer. null null null null null null null null null null null Our current lab results suggest that decreased H3K79 methylation levels are associated null null null null null null null null null null null with decreased DNMT1 activity and binding to the WIF1 5’ region, upregulation of WIF1 null null null null null null null null null null null protein levels, and suppression of Wnt signaling in lung cancer cell lines. W...
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#1Keqiang ZhangH-Index: 17
#2Ting SunH-Index: 2
Last. Dan J. RazH-Index: 17
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#1Wendong Li (City of Hope National Medical Center)H-Index: 9
#2Aviva Rotter-Maskowitz (Weizmann Institute of Science)H-Index: 1
Last. Dan J. Raz (City of Hope National Medical Center)H-Index: 17
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Mutations of the epidermal growth factor receptor (EGFR) are the most common group of actionable mutations in lung cancer, and they predict response to EGFR-tyrosine kinase inhibitos (EGFR-TKIs). The third-generation EGFR-TKI osimertinib is the standard of care for first-line treatment of patients with advanced EGFR-mutated lung cancer. Although most lung cancers with EGFR-mutation respond to osimertinib, resistance is eventually observed in all patients, and there are no approved targeted thera...
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#1Andrew M. Blakely (City of Hope National Medical Center)H-Index: 9
#2Hengrui Hu (City of Hope National Medical Center)
Last. Jae Y. Kim (City of Hope National Medical Center)H-Index: 19
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ABSTRACT Introduction Outcomes of oncologic resection are related to tumor biology and patient-reported health factors. However, data regarding changes in functional status and health-related quality of life (HRQOL) before and after lung surgery for older adults are lacking. Methods We identified lung cancer patients from the SEER-Medicare Health Outcomes Survey (MHOS) linked database. HRQOL surveys captured physical/mental health, activities of daily living (ADLs), and medical comorbidities. Pa...
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#1Loretta Erhunmwunsee (City of Hope National Medical Center)H-Index: 11
#2Sam E. Wing (City of Hope National Medical Center)
Last. Stacy W. Gray (City of Hope National Medical Center)H-Index: 31
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BACKGROUND Poor patients often reside in neighborhoods of lower socioeconomic status (SES) with high levels of airborne pollutants. They also have higher mortality from non-small cell lung cancer (NSCLC) than those living in wealthier communities. We investigated whether living in polluted neighborhoods is associated with somatic mutations linked with lower survival rates, i.e TP53 mutations. METHODS In a retrospective cohort of 478 NSCLC patients treated at a comprehensive cancer center between...
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#1Ernesto Sosa (City of Hope National Medical Center)H-Index: 1
#2Gail D’Souza (City of Hope National Medical Center)
Last. Loretta Erhunmwunsee (City of Hope National Medical Center)H-Index: 11
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Nonsmall cell lung cancer (NSCLC) is the leading cause of cancer deaths. Lung cancer screening (LCS) reduces NSCLC mortality; however, a lack of diversity in LCS studies may limit the generalizability of the results to marginalized groups who face higher risk for and worse outcomes from NSCLC. Identifying sources of inequity in the LCS pipeline is essential to reduce disparities in NSCLC outcomes. The authors searched 3 major databases for studies published from January 1, 2010 to February 27, 2...
1 CitationsSource
#1Andrew M. Blakely (City of Hope National Medical Center)H-Index: 9
#2Hengrui Hu (City of Hope National Medical Center)
Last. Virginia Sun (City of Hope National Medical Center)H-Index: 29
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Abstract Background Lung cancer disproportionately affects older adults. Surgical treatment may result in decreased functional status and health-related quality of life (HRQOL). Population-based data about patient-reported health outcomes for patients with early-stage lung cancer who do not undergo surgery is lacking. Methods We identified lung cancer patients with localized disease from the SEER-Medicare Health Outcomes Survey (MHOS) linked database. Patients with baseline HRQOL survey prior to...
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#1Dan J. Raz (City of Hope National Medical Center)H-Index: 17
#2Mohamed H Ismail (KP: Kaiser Permanente)H-Index: 3
Last. Michael K. Gould (KP: Kaiser Permanente)H-Index: 67
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Abstract Background Lung cancer screening (LCS) with low-dose computed tomography (LDCT) reduces lung cancer mortality in high-risk patients, but most of those eligible are not referred for screening, and most eligible smokers are not aware of LCS. Smoking cessation counseling may be an opportune time to educate smokers about LCS. Here we investigate the effect of LCS educational information on LDCT utilization and smoking cessation in LCS-eligible patients receiving smoking cessation counseling...
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#1Ting Sun (City of Hope National Medical Center)H-Index: 2
#2Keqiang Zhang (City of Hope National Medical Center)H-Index: 17
Last. Dan J. Raz (City of Hope National Medical Center)H-Index: 17
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Potential roles of euchromatic histone methyltransferase 2 (EHMT2 or G9a) in invasion and metastasis are not well understood in non–small cell lung cancer (NSCLC). Here, we investigated the effect and underlying mechanisms of G9a and therapeutic implications of targeting G9a in the invasion and metastasis of NSCLC. Overexpression of G9a significantly enhanced in vitro proliferation and invasion, while knockdown of G9a drastically suppressed in vivo growth and metastasis of A549 and H1299 NSCLC c...
1 CitationsSource