Paweł Niemiec
Medical University of Silesia
GeneInternal medicineEndocrinologyGenotypeCase-control studyPolymorphism (computer science)Single-nucleotide polymorphismMolecular biologyOdds ratioCardiologyAlleleCoronary artery diseasePediatric strokeP22phoxAllele frequencyGeneticsBioinformaticsMedicineGene polymorphismBiologyGastroenterology
Publications 47
#2Andrzej LorekH-Index: 2
Last. Paweł NiemiecH-Index: 10
view all 11 authors...
Background: The multifocality and multicentrality of breast cancer (MFMCC) are the significant aspects that determine a specialist’s choice between applying breast-conserving therapy (BCT) or performing a mastectomy. This study aimed to assess the usefulness of mammography (MG), contrast-enhanced spectral mammography (CESM), and magnetic resonance imaging (MRI) in women diagnosed with breast cancer before qualifying for surgical intervention to visualize other (additional) cancer foci. Methods: ...
#1Tomasz Iwanicki (University of Silesia in Katowice)H-Index: 7
#2Anna Balcerzyk (University of Silesia in Katowice)H-Index: 10
Last. Władysław Grzeszczak (University of Silesia in Katowice)H-Index: 30
view all 12 authors...
The aim of the study was to perform family-based association analysis of PRKCB1, CBLN1 and KCNMB4 gene polymorphisms and autism disorder. We comprised 206 Caucasian children with autistic spectrum disorder (ASD) and their biological parents. In transmission/disequilibrium test we observed that T-allele of the rs198198 polymorphism of the PRKCB1 gene was more often transmitted to affected children in the male subgroup (p = 0.010). Additionally, the T carrier state was significantly associated wit...
#1Katarzyna Steinhof-Radwańska (Medical University of Silesia)H-Index: 1
#2Anna Grażyńska (Medical University of Silesia)H-Index: 2
Last. Jakub PotocznyH-Index: 1
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Background: Evaluating the tumor response to neoadjuvant chemotherapy is key to planning further therapy of breast cancer. Our study aimed to evaluate the effectiveness of low-energy and subtraction contrast-enhanced spectral mammography (CESM) images in the detection of complete response (CR) for neoadjuvant chemotherapy (NAC) in breast cancer. Methods: A total of 63 female patients were qualified for our retrospective analysis. Low-energy and subtraction CESM images just before the beginning o...
#1Paweł Niemiec (University of Silesia in Katowice)H-Index: 10
#2Karol SzylukH-Index: 5
Last. Tomasz Francuz (University of Silesia in Katowice)H-Index: 12
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BACKGROUND There is variability in individual response to platelet-rich plasma (PRP) therapy in tennis elbow treatment. Genetic variation, especially within genes encoding growth factors may influence the observed inter-individual differences. The purpose of this study was to identify polymorphic variants of the platelet-derived growth factor beta polypeptide gene (PDGFB) that determine an improved individual response to PRP therapy in tennis elbow patients. METHODS This prospective cohort study...
#1Andrzej Lorek (Medical University of Silesia)H-Index: 1
#2Katarzyna Steinhof-Radwańska (Medical University of Silesia)H-Index: 1
Last. Iwona GisterekH-Index: 2
view all 10 authors...
Contrast-enhanced spectral mammography (CESM) is a promising, digital breast imaging method for planning surgeries. The study aimed at comparing digital mammography (MG) with CESM as predictive factors in visualizing multifocal-multicentric cancers (MFMCC) before determining the surgery extent. We analyzed 999 patients after breast cancer surgery to compare MG and CESM in terms of detecting MFMCC. Moreover, these procedures were assessed for their conformity with postoperative histopathology (HP...
#1Joanna IwanickaH-Index: 3
#2Tomasz IwanickiH-Index: 7
Last. Iwona ŻakH-Index: 7
view all 10 authors...
#1Tomasz Iwanicki (Medical University of Silesia)H-Index: 7
#2Anna Balcerzyk (Medical University of Silesia)H-Index: 10
Last. Iwona Żak (Medical University of Silesia)H-Index: 7
view all 9 authors...
: Polymorphic variants of the CYP7A1 gene can increase the risk of atherosclerosis-based coronary artery disease (CAD) and modify serum lipid markers. Method: We studied haplotype-tagging single nucleotide polymorphisms of CYP7A1 in the Caucasian population and if they are associated with CAD, its symptoms, and any of its risk factors. Results: We did not find the genetic variants of CYP7A1 to be associated with an increased risk of CAD. However, we did find that the common rs3808607 variant is ...
#1Tomasz Nowak (Medical University of Silesia)H-Index: 6
#2Paweł Niemiec (Medical University of Silesia)H-Index: 10
Last. Iwona Zak (Medical University of Silesia)H-Index: 13
view all 7 authors...
AbstractThe p22phox is a critical component of vascular NADPH oxidases and is encoded by the CYBA gene. It was shown that functionally relevant polymorphisms of the CYBA gene −930A > G, −852C > G, −675A > T, −536C > T, 214C > T (previously described as 242C > T), *24A > G (previously described as 640A > G), and *49A > G modulate generation of reactive oxygen species (ROS). To analyse whether the CYBA gene polymorphisms −852C > G, −675A > T, and −536C > T were associated with coronary artery dise...
#1Joanna Iwanicka (Medical University of Silesia)H-Index: 3
#2Tomasz Iwanicki (Medical University of Silesia)H-Index: 7
Last. Iwona Żak (Medical University of Silesia)H-Index: 7
view all 9 authors...
The cholesteryl ester transfer protein (CETP) gene encodes a hydrophobic glycoprotein that plays a crucial role in the reverse transport of cholesterol. The aim of the present study was to determine whether CETP polymorphisms (rs1532624, rs247616 and rs708272) are associated with coronary artery disease (CAD) in a Polish population. Serum lipid levels and single nucleotide polymorphisms of CETP genes were determined in 494 subjects: 248 patients with premature CAD and 246 blood donors as control...
#1Anna Balcerzyk (University of Silesia in Katowice)H-Index: 10
#2Paweł Niemiec (University of Silesia in Katowice)H-Index: 10
Last. Iwona Żak (University of Silesia in Katowice)H-Index: 7
view all 13 authors...
Background Pediatric ischemic stroke is an important cause of morbidity and mortality. As previous studies of children after stroke showed, dyslipidemias were very common in Polish and other European populations. Thus, looking for genetic factors predisposing to pediatric stroke, its symptoms, and outcome, we have analyzed 2 polymorphisms of the upstream stimulating factor 1 (USF-1) gene. Materials and Methods The study group consisted of 82 children with stroke, 156 parents, and 146 controls. W...
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