Delong Zhang
Zhejiang University
Analytical chemistryTemporal resolutionOpticsBiophysicsMicroscopyInfraredHyperspectral imagingFemtosecondRaman scatteringPhotothermal therapyChemistryMaterials scienceImage resolutionLabel freeRaman spectroscopyNuclear magnetic resonanceOptoelectronicsLaserChemical imagingMicroscope
Publications 41
#1Weiru FanH-Index: 1
Last. Shi-Yao ZhuH-Index: 62
view all 9 authors...
Optical phase contains key information for biomedical and astronomical imaging. However, it is often obscured by layers of heterogeneous and scattering media, which render optical phase imaging at different depths an utmost challenge. Limited by the memory effect, current methods for phase imaging in strong scattering media are inapplicable to retrieving phases at different depths. To address this challenge, we developed a speckle three-dimensional reconstruction network (STRN) to recognize phas...
#4Da-Wei Wang (ZJU: Zhejiang University)H-Index: 18
#5Delong Zhang (ZJU: Zhejiang University)H-Index: 22
Raman spectroscopy provides a non-invasive, chemically-specific optical imaging of biological objects without relying on endogenous labels. Nonlinear Raman spectroscopy allows non-invasive imaging at much faster speed with an improved spatial resolution and axial sectioning capability. In this report we propose a novel use of nonlinear Raman spectroscopy as a sensor of local nano-environment. Time-resolved coherent anti-Stokes Raman spectrograms are found to be sensitive to small variations of l...
#1Tianrun Chen (ZJU: Zhejiang University)
#2Weiru Fan (ZJU: Zhejiang University)H-Index: 1
Last. Delong Zhang (ZJU: Zhejiang University)H-Index: 22
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Optical phase microscopy is widely adopted for quantitative imaging of optical density in transparent cells and tissues that lack absorption contrast. Fundamentally, the phase information of the sample is contained in the wavefront of the probe beam, often detected by interferometry-based techniques. Here, a novel approach has been developed based on the phase-sensitive second harmonic signals that are generated after the sample. A deep learning algorithm is developed for efficient recovery of t...
#1Hanlin Zhu (ZJU: Zhejiang University)
#2Vladislav V. Yakovlev (A&M: Texas A&M University)H-Index: 45
Last. Delong Zhang (ZJU: Zhejiang University)H-Index: 22
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Vibrational spectroscopy is widely used for a large variety of sensing and imaging applications. Nonlinear optical interactions using ultrashort laser pulses can facilitate selective coherent excitation of molecular vibrational modes, such as stretching and bending C-H and O-H vibrational modes. However, such spectroscopic probes are often based on the assumption that the energy distribution is static throughout the system, neglecting complex molecular dynamics and the effects of local nano- and...
#1Pengcheng Fu (ZJU: Zhejiang University)
#2Tianrun Chen (ZJU: Zhejiang University)
Last. Delong Zhang (ZJU: Zhejiang University)H-Index: 22
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Infrared (IR) spectroscopy depicts molecular structure and dynamics based on vibrational absorption of chemical bonds. Spatially resolved IR spectroscopy, i.e. IR imaging, further enabled label-free in situ chemical imaging for dynamics in complex systems. However, IR imaging suffers from low spatial resolution at a few micrometers due to diffraction limit, thus having difficulty in applications such as sub-cellular imaging. Recently, by visible light probing of the photothermal effect of vibrat...
#4Shi-Yao Zhu (ZJU: Zhejiang University)H-Index: 62
Wavefront sensing and reconstruction are widely used for adaptive optics, aberration correction, and high-resolution optical phase imaging. Traditionally, interference and/or microlens arrays are used to convert the optical phase into intensity variation. Direct imaging of distorted wavefront usually results in complicated phase retrieval with low contrast and low sensitivity. Here, a novel approach has been developed and experimentally demonstrated based on the phase-sensitive information encod...
#1Anton D. ShutovH-Index: 5
#2Georgi I. PetrovH-Index: 19
Last. Vladislav V. YakovlevH-Index: 45
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Coherent Raman microspectroscopy utilizing either stimulated Raman scattering or coherent Raman scattering is gaining popularity in the field of biological imaging. It is generally assumed that coherent Raman spectroscopy provides a stronger signal than conventional spectroscopy based on spontaneous scattering, allowing much faster imaging. In this report we examine non-trivial advantages of coherent Raman microspectroscopy, which haven’t been given significant attention lately. In particular, w...
#1Delong Zhang (ZJU: Zhejiang University)H-Index: 22
#2Lu Lan (BU: Boston University)H-Index: 14
Last. Ji-Xin Cheng (BU: Boston University)H-Index: 84
view all 7 authors...
Phase-contrast microscopy converts the phase shift of light passing through a transparent specimen, e.g., a biological cell, into brightness variations in an image. This ability to observe structures without destructive fixation or staining has been widely utilized for applications in materials and life sciences. Despite these advantages, phase-contrast microscopy lacks the ability to reveal molecular information. To address this gap, we developed a bond-selective transient phase (BSTP) imaging ...
#1Xiaojie Li (CAS: Chinese Academy of Sciences)H-Index: 3
#2Delong ZhangH-Index: 22
Last. Ji-Xin ChengH-Index: 84
view all 6 authors...
Vibrational spectroscopic imaging techniques, based on infrared absorption or Raman scattering, allow for noninvasive chemically specific visualization of biological systems. The infrared and Raman modalities with different selection rules provide complementary information. Specifically, infrared microscopy provides strong signals in the fingerprint region, but suffers from low spatial resolution. Raman microscopy provides submicrometer resolution, but requires a long acquisition time. We develo...
#1Yeran BaiH-Index: 5
#2Delong Zhang (BU: Boston University)H-Index: 22
Last. Ji-Xin ChengH-Index: 84
view all 7 authors...
Infrared (IR) imaging has become a viable tool for visualizing various chemical bonds in a specimen. The performance, however, is limited in terms of spatial resolution and imaging speed. Here, instead of measuring the loss of the IR beam, we use a pulsed visible light for high-throughput, widefield sensing of the transient photothermal effect induced by absorption of single mid-IR pulses. To extract these transient signals, we built a virtual lock-in camera synchronized to the visible probe and...
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