Cristina D'Arrigo
National Research Council
Nuclear matrixMatrix metalloproteinasePeptidomimeticBiophysicsCircular dichroismProtein aggregationCellGene expressionMolecular biologyCytotoxic T cellLaminChemistryMaterials scienceIn vitroCombinatorial chemistryFibrilNeurodegenerationPeptideNeurotoxicityOligomerNuclear proteinß amyloidProgrammed cell deathProtein structureAlzheimer's diseaseCancer researchDNABiochemistryRNAChromatinBiologyAmyloidCell biology
42Publications
19H-index
1,082Citations
Publications 42
Newest
#1Roberta Pece (UniGe: University of Genoa)H-Index: 2
#2Sara Tavella (UniGe: University of Genoa)H-Index: 17
Last. Cristina D'ArrigoH-Index: 19
view all 16 authors...
Shedding of A Disintegrin And Metalloproteinases (ADAM10) substrates, like TNFα or CD30, can affect both anti-tumor immune response and antibody-drug-conjugate (ADC)-based immunotherapy. We have published two new ADAM10 inhibitors, LT4 and MN8 able to prevent such shedding in Hodgkin lymphoma (HL). Since tumor tissue architecture deeply influence the outcome of anti-cancer treatments, we set up new three-dimensional (3D) culture systemsto verify whether ADAM10 inhibitors can contribute to, or en...
Source
#1Sonia SpinelliH-Index: 3
#2Giulia BeganiH-Index: 1
Last. Elena ZocchiH-Index: 45
view all 11 authors...
Abstract null null Objective null Abscisic acid (ABA) is a plant hormone also present and active in animals. In mammals, ABA regulates blood glucose levels by stimulating insulin-independent glucose uptake and metabolism in adipocytes and myocytes, through its receptor LANCL2. The objective of this study was to investigate whether another member of the LANCL protein family, LANCL1, also behaves as an ABA receptor and, if so, which functional effects are mediated by LANCL1. null null null Methods...
1 CitationsSource
#1Simona TomaselliH-Index: 15
#2Pietro La VitolaH-Index: 10
Last. Laura RagonaH-Index: 25
view all 16 authors...
In this study natural-based complex polyphenols, obtained through a smart synthetic approach, have been evaluated for their ability to inhibit the formation of Aβ42 oligomers, the most toxic species causing synaptic dysfunction, neuroinflammation and neuronal death leading to the onset and progression of Alzheimer’s Disease. In vitro neurotoxicity tests on primary hippocampal neurons have been employed to select non-toxic candidates. Solution NMR and molecular docking studies have been performed...
10 CitationsSource
#1Denise GalanteH-Index: 7
#2Luca BanfiH-Index: 31
Last. Chiara LambruschiniH-Index: 9
view all 9 authors...
While plant polyphenols possess a variety of biological properties, exploration of chemical diversity around them is still problematic. Here, an example of application of the Ugi multicomponent reaction to the combinatorial assembly of artificial, yet “natural-like”, polyphenols is presented. The synthesized compounds represent a second-generation library directed to the inhibition of β-amyloid protein aggregation. Chiral enantiopure compounds, and polyphenol-β-lactam hybrids have been prepared ...
4 CitationsSource
#1Felicia D'Andrea (UniPi: University of Pisa)H-Index: 19
#2Elisa Nuti (UniPi: University of Pisa)H-Index: 25
Last. Armando Rossello (UniPi: University of Pisa)H-Index: 28
view all 15 authors...
: Selective and potent matrix metalloproteinase 12 (MMP-12) inhibitors endowed with improved hydrophilicity are highly sought for potential use in the treatment of lung and cardiovascular diseases. In the present paper, we modified the structure of a nanomolar MMP-12 inhibitor by incorporating an ionic liquid (IL) moiety to improve aqueous solubility. Four biologically active salts were obtained by linking the sulfonamide moiety of the MMP-12 inhibitor to imidazolium-, pyrrolidinium-, piperidini...
2 CitationsSource
#1Katiuscia PaganoH-Index: 11
#2Denise GalanteH-Index: 7
Last. Laura RagonaH-Index: 25
view all 9 authors...
Soluble Aβ oligomers are widely recognized as the toxic forms responsible for triggering AD, and Aβ receptors are hypothesized to represent the first step in a neuronal cascade leading to dementia. Cellular prion protein (PrP) has been reported as a high-affinity binder of Aβ oligomers. The interactions of PrP with both Aβ42 and the highly toxic N-truncated pyroglutamylated species (AβpE3-42) are here investigated, at a molecular level, by means of ThT fluorescence, NMR and TEM. We demonstrate t...
8 CitationsSource
#1Caterina CamodecaH-Index: 12
#2Elisa Nuti (UniPi: University of Pisa)H-Index: 25
Last. Armando Rossello (UniPi: University of Pisa)H-Index: 28
view all 7 authors...
: A disintegrin and metalloproteinase (ADAMs) are membrane-bound metalloproteases responsible for the ectodomain shedding of various transmembrane proteins and play important roles in multiple relevant biological processes. Their altered expression is involved in several pathological conditions, and in particular ADAM10 or ADAM17 overexpression is found in various forms of cancer. To better understand how they are regulated in the cellular context, it is useful to visualize the specific ADAMs pa...
6 CitationsSource
#1Denise Galante (National Research Council)H-Index: 7
#2E. CavalloH-Index: 1
Last. Cristina D'Arrigo (National Research Council)H-Index: 19
view all 4 authors...
Amyloid beta (Aβ) aggregation and oxidative stress are two of the central events in Alzheimer's Disease (AD). Both these phenomena can be caused by the interaction of Aβ with metal ions. In the last years the interaction between ZnII , CuII , and Aβ was much studied, but between iron and Aβ it is still little known. In this work we determine how three Aβ peptides, present in AD, interact with FeIII -citrate. The three Aβ peptides are: full length Aβ1-42, an isoform truncated at Glutamic acid in ...
5 CitationsSource
#1Francesca TosettiH-Index: 21
#2Roberta VenèH-Index: 22
Last. Maria Raffaella ZocchiH-Index: 42
view all 10 authors...
ABSTRACTShedding of ADAM10 substrates, like TNFα, MICA or CD30, is reported to affect both anti-tumor immune response and antibody-drug-conjugate (ADC)-based immunotherapy. Soluble forms of these molecules and ADAM10 can be carried and spread in the microenvironment by exosomes released by tumor cells. We reported new ADAM10 inhibitors able to prevent MICA shedding in Hodgkin lymphoma (HL), leading to recognition of HL cells by cytotoxic lymphocytes.In this paper, we show that the mature bioacti...
18 CitationsSource
A new and short fragment-based approach towards artificial (but “natural-based”) complex polyphenols has been developed, exploiting the Ugi multicomponent reaction of phenol-containing simple substrates. The resulting library of compounds has been tested for its capacity to inhibit β-amyloid protein aggregation, as a possible strategy to develop new chemical entities to be used as prevention or therapy for Alzheimer's disease. Some of the members of this library have demonstrated, in thioflavin ...
14 CitationsSource