Liangliang Xu
Guangzhou University of Chinese Medicine
Regenerative medicineInternal medicineEndocrinologyPathologymicroRNARegeneration (biology)ChemistryMesenchymal stem cellImmunologyIn vivoRUNX2Bone marrowOsteopontinStem cellBone regenerationCancer researchSignal transductionMedicineBone healingBiologyCell biology
62Publications
22H-index
1,446Citations
Publications 63
Newest
#2Min Wang (Guangzhou University of Chinese Medicine)
Last. Li G
view all 12 authors...
Source
#1Yonghui Hou (Guangzhou University of Chinese Medicine)H-Index: 6
#2Weiping Lin (CUHK: The Chinese University of Hong Kong)H-Index: 8
Last. Liangliang Xu (Guangzhou University of Chinese Medicine)H-Index: 22
view all 9 authors...
Abstract Background Mesenchymal stem cells (MSCs) are promising targets for therapeutic use in regenerative medicine and tissue engineering. In the previous study, we have found that MSCs could be reverted to a primitive stem cell population after in vitro induction of osteogenic and de-osteogenic differentiation (de-osteogenic differentiated MSCs, De-Os-MSCs). De-Os-MSCs showed improved cell survival and osteogenic potential. However, the underlying mechanism and its potential effect on fractur...
1 CitationsSource
#1Jun-Lang Zhu (Guangzhou University of Chinese Medicine)H-Index: 3
#2Yamei Liu (Guangzhou University of Chinese Medicine)H-Index: 9
Last. Wang Bin (Guangzhou University of Chinese Medicine)H-Index: 4
view all 14 authors...
Abstract Background Mesenchymal Stem Cells (MSCs) therapy has become a new coming focus of clinical research in regenerative medicine. However, only a small number of implanted MSCs could successfully reach the injured areas. The previous studies have shown that fracture healing time is inversely proportional to concentration of MSCs in injured tissue. Methods The migration and osteogenesis of MSCs were assessed by transwell assay and Alizarin Red S staining. Levels of gene and protein expressio...
Source
#1Weiping Lin (CUHK: The Chinese University of Hong Kong)H-Index: 8
#2Liangliang Xu (Guangzhou University of Chinese Medicine)H-Index: 22
Last. Gang Li (CUHK: The Chinese University of Hong Kong)H-Index: 84
view all 3 authors...
Source
#1Ying-Shan Shen (Guangzhou University of Chinese Medicine)H-Index: 3
#2Xiao-Jun Chen (Guangzhou University of Chinese Medicine)H-Index: 3
Last. Qiushi WeiH-Index: 10
view all 8 authors...
Polydatin (PD), extracted from Polygonum cuspidatum, has shown potential therapeutic applications due to its antiosteoporotic and anti-inflammatory activities. Our previous study suggested that PD promotes the osteogenesis of human bone marrow stromal cells (hBMSCs) via the BMP2-Wnt/β-catenin pathway. The aim of our present study was to further explore the role of PD-mediated regulation of Tafazzin (TAZ), a transcriptional coactivator with a PDZ-binding motif, in osteogenesis. hBMSCs were isolat...
2 CitationsSource
#1Yamei Liu (Guangzhou University of Chinese Medicine)H-Index: 9
#2Liangliang Xu (Guangzhou University of Chinese Medicine)H-Index: 22
Last. Gang Li (CUHK: The Chinese University of Hong Kong)H-Index: 84
view all 12 authors...
Abstract Mesenchymal stem cells (MSCs) can be easily expanded without losing the ability of multilineage differentiation, including oesteogenic, chondrogenic and adipogenic differentiation. These characters make MSCs a promising cell resource for cartilage defect repair. MSCs could be recruited by inflammatory stimulation, then home to the injury tissues. However, its capacity of homing is extremely limited. Thus, it has become extremely necessary to develop an agent or a method, which can be us...
2 CitationsSource
#1Weiping Lin (CUHK: The Chinese University of Hong Kong)H-Index: 8
#2Liangliang Xu (Guangzhou University of Chinese Medicine)H-Index: 22
Last. Gang Li (CUHK: The Chinese University of Hong Kong)H-Index: 84
view all 3 authors...
: Articular cartilage remains among the most difficult tissues to regenerate due to its poor self-repair capacity. The lysyl oxidase family (LOX; also termed as protein-lysine 6-oxidase), mainly consists of lysyl oxidase (LO) and lysyl oxidase-like 1-4 (LOXL1-LOXL4), has been traditionally defined as cuproenzymes that are essential for stabilization of extracellular matrix, particularly cross-linking of collagen and elastin. LOX is essential in the musculoskeletal system, particularly cartilage....
4 CitationsSource
#1Jiaqian Zheng (Guangzhou University of Chinese Medicine)H-Index: 3
#2Yanni Huang (Guangzhou University of Chinese Medicine)H-Index: 1
Last. Bin Fang (Guangzhou University of Chinese Medicine)H-Index: 6
view all 10 authors...
Mounting evidences have indicated that terminal differentiation-induced lncRNA (TINCR) contributes to various cellular processes, such as proliferation, apoptosis, autophagy, migration, invasion, and metastasis. However, the function of TINCR in regulating migration of MSCs is largely unknown. In this study, the effects of TINCR on the migration of rat MSCs from the bone marrow were studied by Transwell assays and wound healing assays. Our results suggested that TINCR positively regulated migrat...
5 CitationsSource
#1Ying Li (Guangzhou University of Chinese Medicine)H-Index: 5
#2Jinglan Li (Guangzhou University of Chinese Medicine)H-Index: 1
Last. Liangliang Xu (Guangzhou University of Chinese Medicine)H-Index: 22
view all 4 authors...
The human genome project (HGP) announced in 2001 that it had sequenced the entire human genome, yielding nearly complete human DNA. About 98.5 percent of human genome has been found to be non-coding sequences. Long non-coding RNA (lncRNA) is a non-coding RNA with a length between 200 and 100,000 nucleotide units. Because of shallow research on lncRNA, it was believed that it had no biological functions, but exists as a by-product of the transcription process. With the development of high-through...
3 CitationsSource
#1Liangliang Xu (Guangzhou University of Chinese Medicine)H-Index: 22
#2Weiping Lin (CUHK: The Chinese University of Hong Kong)H-Index: 8
Last. Gang Li (CUHK: The Chinese University of Hong Kong)H-Index: 84
view all 4 authors...
Cancer remains one of the leading lethal diseases worldwide. Identifying biomarkers of cancers might provide insights into the strategies for the development of novel targeted anti-cancer therapies. Leucine-rich repeat-containing G protein-coupled receptor 5 (Lgr5) has been recently discovered as a candidate marker of cancer stem cell populations. Aberrant increased expression of Lgr5 may represent one of the most common molecular alterations in some human cancers, leading to long-term potentiat...
15 CitationsSource