Young Hoon Roh
Yonsei University
Self-healing hydrogelsBiophysicsDNA nanotechnologyOligonucleotidePolyelectrolyteNanoparticleRNA interferenceNanotechnologyNanocarriersChemistryPolymer chemistryMaterials scienceNucleic acidDrug deliveryControlled deliveryTranscription (biology)Chemical engineeringDNARNAMedicineRolling circle replicationBiologyCell biologyCancer cell
35Publications
13H-index
1,059Citations
Publications 42
Newest
#1Hyung Sun Yoon (Yonsei University)H-Index: 1
#2Kyungjik Yang (Yonsei University)H-Index: 6
Last. Young Hoon Roh (Yonsei University)H-Index: 13
view all 5 authors...
Abstract null null The selection of sacrificial support materials is important in the fabrication of complex freeform structures. In this study, a dual droplet-based, freeform 3D printing method for pseudoplastic alginate biomaterial inks was developed using Bingham plastic cellulose nanocrystals (CNCs) as support nanomaterials. CNCs-CaCl2 mixture compositions and alginate concentrations were varied to enhance printability with rheological properties of shape fidelity and structural stability. T...
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Cardiac angiography to visualize the cardiac coronary artery for lesions causes a lot of radiation exposure dose to the interventional cardiologist. We evaluated the occupational radiation exposure to the interventional cardiologist based on changes to the angle of the X-ray tube used in cardiac angiography and calculated the conversion factor for effective dose in this study. To evaluate the occupational radiation exposure resulting from scattered radiation to interventional cardiologists, orga...
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Highly pathogenic avian influenza viruses (HPAIVs) pose a significant threat to human health, with high mortality rates and require effective vaccines. We showed that, harnessed with novel RNA-mediated chaperone function, hemagglutinin (HA) of H5N1 HPAIV could be displayed as an immunologically relevant conformation on self-assembled chimeric nanoparticles (cNP). A tri-partite monomeric antigen was designed including: i) an RNA-interaction domain (RID) as a docking tag for RNA to enable chaperna...
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#1Keonwook Nam (Yonsei University)H-Index: 5
#2Byeol I Im (Yonsei University)
Last. Young Hoon Roh (Yonsei University)H-Index: 13
view all 5 authors...
The development of supramolecular hydrogel scaffolds for the precise positioning of biochemical cues is paramount for applications such as tissue engineering. Nucleic acid engineering allows fabrication of three-dimensional (3D) nanostructures with high variability and nanoscale precision. In this study, aptamers were anisotropically functionalized onto branched DNA nanostructures to control their cell adhesion capability, and their efficiency as biological signal inducers for 3D cell cultivatio...
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In radiography, the exposure index (EI), as per the International Electrotechnical Commission standard, depends on the incident beam quality and exposure dose to the digital radiography system. Today automatic exposure control (AEC) systems are commonly employed to obtain the optimal image quality. An AEC system can maintain a constant incident exposure dose on the image receptor regardless of the patient thickness. In this study, we investigated the relationship between body thickness, entrance...
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#1Beom Jeung Hwang (Yonsei University)H-Index: 3
#2Yohan Jang (Andong National University)H-Index: 1
Last. Baik Lin Seong (Yonsei University)H-Index: 39
view all 7 authors...
Abstract Representing highly ordered repetitive structures of antigen macromolecular assemblies, virus-like particles (VLPs) serve as a high-priority vaccine platform against emerging viral infections, as alternatives to traditional cell culture-based vaccines. RNAs can function as chaperones (Chaperna) and are extremely effective in promoting protein folding. Beyond their canonical function as translational adaptors, tRNAs may moonlight as chaperones for the kinetic control of macromolecular an...
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#1Taehyung Kim (Yonsei University)H-Index: 5
#2Keonwook Nam (Yonsei University)H-Index: 5
Last. Young Hoon Roh (Yonsei University)H-Index: 13
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Due to powerful breakthroughs in nanotechnology, smart delivery mechanisms have rapidly emerged for use in diverse applications across biomedical research and therapeutic development. Recent efforts toward understanding stimuli-responsive strategies have led to substantial improvements in their conceptual application and in vitro efficiency. Because disease targets for therapy are often localized in specific cells, organs, or tissues, an enhanced permeability and retention (EPR)-based strategy r...
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#1Kyungsene Lee (PSU: Pennsylvania State University)H-Index: 1
#2Taehyung Kim (Yonsei University)H-Index: 5
Last. Young Hoon Roh (Yonsei University)H-Index: 13
view all 6 authors...
Targeted, stimulus-responsive DNA nanogels hold considerable promise for cancer therapeutics. To expand their functionality including thermoresponsiveness, here, multifunctional DNA nanogels are developed for potential application toward cancer-targeted delivery and stimuli-responsive release of cancer therapeutics. Three types of functionalized DNA nanobuilding units are formed into DNA nanogels of ≈200 nm via sequence-dependent self-assembly. The sequence-dependent assembly of nanobuilding uni...
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#1Jeong Un Kim (Yonsei University)H-Index: 9
#2Hafiz Muhammad Shahbaz (UVAS: University of Veterinary and Animal Sciences)H-Index: 16
Last. Jiyong Park (Yonsei University)H-Index: 26
view all 7 authors...
Abstract Although oral administration is the most favorable mode of insulin delivery, it is the most challenging route, owing to poor oral bioavailability. In this study, a chitosan (CS)-based insulin delivery system was developed by ionic crosslinking with phytic acid (PA). CS-PA microspheres were optimized with different crosslinking conditions of CS and PA using response surface methodology to retain insulin during preparation and gastric digestion. Furthermore, the in vitro release profile, ...
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#1Young Hoon Roh (KU: Korea University)H-Index: 13
During interventional cardiological procedures, operators are exposed to patients’ scatter radiation. Therefore, we measured the radiation exposure of the operator’s eyeball, thyroid, and chest wall during angiography. We used the optically stimulated luminescence dosimeter in the anthropomorphic phantom and developed Monte Carlo simulations using the Korean human voxel phantom. At 15 frames/s, the radiation dose of the operator’s right eyeball (RE), left eyeball (LE), thyroid (T), and chest wal...
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