Lynette Phillips
University of Texas MD Anderson Cancer Center
Fusion geneCancerTelomerase reverse transcriptaseDownregulation and upregulationGene deliveryViral replicationPathologymicroRNACorepressorCellular differentiationCellPermissiveRNA interferenceStromal cellChemistrySmall hairpin RNAMesenchymal stem cellProgenitor cellImmunologyMicrovesiclesBreakpointPathologicalSmall interfering RNAVirusGrowth factorGlioblastomaOncolytic adenovirusPTENGliomaHamsterMetastasisNeutralizing antibodyCDKN2ABiomarker (cell)OncogeneAdenocarcinomaKRASStem cellTumor cellsCancer researchViability assayCarcinogenesisSignal transductionMedicineProtein kinase BEpithelial–mesenchymal transitionIntracellularCell cultureOncolytic virusPI3K/AKT/mTOR pathwayBiologyImmune system
11Publications
4H-index
171Citations
Publications 11
Newest
#1Lynette Phillips (University of Texas MD Anderson Cancer Center)H-Index: 4
#2Shoudong Li (University of Texas MD Anderson Cancer Center)H-Index: 1
Last. Frederick F. Lang (University of Texas MD Anderson Cancer Center)H-Index: 76
view all 13 authors...
BACKGROUND Oncolytic adenoviruses are promising new treatments against solid tumors, particularly for glioblastoma (GBM), and preclinical models are required to evaluate the mechanisms of efficacy. However, due to the species selectivity of adenovirus, there is currently no single animal model that supports viral replication, tumor oncolysis, and a virus-mediated immune response. To address this gap, we took advantage of the Syrian hamster to develop the first intracranial glioma model that is b...
Source
#1Malcolm F. McDonald (BCM: Baylor College of Medicine)
#2Anwar Hossain (University of Texas MD Anderson Cancer Center)H-Index: 20
Last. Frederick Lang (University of Texas MD Anderson Cancer Center)H-Index: 10
view all 13 authors...
Source
#1Lynette Phillips (University of Texas MD Anderson Cancer Center)H-Index: 4
#2Joy Gumin (University of Texas MD Anderson Cancer Center)H-Index: 28
Last. Frederick Lang (University of Texas MD Anderson Cancer Center)H-Index: 10
view all 10 authors...
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#1Brittany C. Parker Kerrigan (University of Texas MD Anderson Cancer Center)H-Index: 9
#2Daniel Ledbetter (University of Texas MD Anderson Cancer Center)H-Index: 1
Last. David Cogdell (University of Texas MD Anderson Cancer Center)H-Index: 28
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Background Fusion genes form as a result of abnormal chromosomal rearrangements linking previously separate genes into one transcript. The FGFR3-TACC3 fusion gene (F3-T3) has been shown to drive gliomagenesis in glioblastoma (GBM), a cancer that is notoriously resistant to therapy. However, successful targeting of F3-T3 via small molecular inhibitors has not revealed robust therapeutic responses, and specific targeting of F3-T3 has not been achieved heretofore. Here, we demonstrate that depletin...
Source
#1Malcolm McDonald (University of Texas MD Anderson Cancer Center)
#2Irtiza Hasan (University of Texas MD Anderson Cancer Center)H-Index: 4
Last. Frederick Lang (University of Texas MD Anderson Cancer Center)H-Index: 10
view all 13 authors...
Source
#1Anwar Hossain (University of Texas MD Anderson Cancer Center)H-Index: 20
#2Irtiza Hasan (University of Texas MD Anderson Cancer Center)H-Index: 4
Last. Frederick Lang (University of Texas MD Anderson Cancer Center)H-Index: 10
view all 10 authors...
Source
#1Lynette Phillips (University of Texas MD Anderson Cancer Center)H-Index: 4
#2Shoudong Li (University of Texas MD Anderson Cancer Center)H-Index: 1
Last. Frederick Lang (University of Texas MD Anderson Cancer Center)H-Index: 10
view all 9 authors...
Source
#1Javier Figueroa (University of Texas MD Anderson Cancer Center)H-Index: 1
#1Javier Figueroa (University of Texas MD Anderson Cancer Center)H-Index: 1
Last. Frederick F. Lang (University of Texas MD Anderson Cancer Center)H-Index: 76
view all 13 authors...
Tumor–stromal communications impact tumorigenesis in ways that are incompletely understood. Here, we show that glioma-associated human mesenchymal stem cells (GA-hMSC), a newly identified stromal component of glioblastoma, release exosomes that increase the proliferation and clonogenicity of tumor-initiating glioma stem-like cells (GSC). This event leads to a significantly greater tumor burden and decreased host survival compared with untreated GSCs in orthotopic xenografts. Analysis of the exos...
90 CitationsSource
#1Song Gao (University of Texas MD Anderson Cancer Center)H-Index: 8
#1Song Gao (University of Texas MD Anderson Cancer Center)H-Index: 8
Last. Wei Zhang (Wake Forest Baptist Medical Center)H-Index: 19
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The molecular basis underlying the particularly aggressive nature of pancreatic ductal adenocarcinoma (PDAC) still remains unclear. Here we report evidence that the insulin-like growth factor–binding protein IGFBP2 acts as a potent oncogene to drive its extremely malignant character. We found that elevated IGFBP2 expression in primary tumors was associated with lymph node metastasis and shorter survival in patients with PDAC. Enforced expression of IGFBP2 promoted invasion and metastasis of PDAC...
40 CitationsSource
#1Lynette Phillips (University of Texas MD Anderson Cancer Center)H-Index: 4
#2Xinhui Zhou (University of Texas MD Anderson Cancer Center)H-Index: 4
Last. Wei ZhangH-Index: 19
view all 8 authors...
Insulin-like growth factor binding protein 2 (IGFBP2) overexpression is common in high-grade glioma and is both a strong biomarker of aggressive behaviour and a well-documented prognostic factor. IGFBP2 is a member of the secreted IGFBP family that functions by interacting with circulating IGFs to modulate IGF-mediated signalling. This traditional view of IGFBP2 activities has been challenged by the recognition of the diverse functions and cellular locations of members of the IGFBP family. IGFBP...
23 CitationsSource