Lars Norgren
Örebro University
Internal medicineRadiologyEndocrinologySurgeryPathologyCardiologyIn vivoAneurysmVascular surgeryAortic aneurysmVascular diseaseRevascularizationIntermittent claudicationAbdominal aortic aneurysmStenosisAngiographyCritical limb ischemiaIn patientAnesthesiaIschemiaMedicinePlatelet
361Publications
61H-index
15kCitations
Publications 164
Newest
#1Manesh R. Patel (Duke University)H-Index: 104
#2Gretchen M. Heizer (Duke University)H-Index: 13
Last. William R. Hiatt (Duke University)H-Index: 96
view all 13 authors...
Cytochrome P450 2C19 (CYP2C19) is a hepatic enzyme involved in metabolism of clopidogrel to its active metabolite. Polymorphisms with 2 loss-of-function (LOF) alleles lead to poor metabolism of clopidogrel, but little is known about the effects of both heterozygous state for LOF and gain-of-function
Source
#1William S Jones (Duke University)H-Index: 11
#2Rachael Ward (Duke University)H-Index: 2
Last. Manesh R. Patel (Duke University)H-Index: 104
view all 16 authors...
Rates and predictors of major bleeding events in patients with peripheral artery disease (PAD) treated with antiplatelet medications are not known. This post-hoc analysis of EUCLID aimed to (1) determine the incidence of minor/major bleeding; (2) determine the predictors of major bleeding; and (3)
1 CitationsSource
#1Connie N. Hess (University of Colorado Denver)H-Index: 21
#2Lars NorgrenH-Index: 61
Last. William R. Hiatt (University of Colorado Denver)H-Index: 96
view all 11 authors...
Peripheral artery disease affects >200 million people worldwide and is associated with significant limb and cardiovascular morbidity and mortality. Limb revascularization is recommended to improve function and quality of life for symptomatic patients with peripheral artery disease with intermittent claudication who have not responded to medical treatment. For patients with critical limb ischemia, the goals of revascularization are to relieve pain, help wound healing, and prevent limb loss. The b...
84 CitationsSource
#1William R. Hiatt (Edin.: University of Edinburgh)H-Index: 96
#2F. Gerry R. Fowkes (Duke University)H-Index: 2
Last. Manesh R. Patel (Duke University)H-Index: 104
view all 14 authors...
BackgroundPeripheral artery disease is considered to be a manifestation of systemic atherosclerosis with associated adverse cardiovascular and limb events. Data from previous trials have suggested that patients receiving clopidogrel monotherapy had a lower risk of cardiovascular events than those receiving aspirin. We wanted to compare clopidogrel with ticagrelor, a potent antiplatelet agent, in patients with peripheral artery disease. MethodsIn this double-blind, event-driven trial, we randomly...
311 CitationsSource
Source
#1Michael R. Jaff (Harvard University)H-Index: 89
#2Christopher J. White (UQ: University of Queensland)H-Index: 88
Last. Lars Norgren (Örebro University)H-Index: 61
view all 8 authors...
The Inter-Society Consensus for the Management of Peripheral Arterial Disease (TASC) guidelines were last updated in 2007 (TASC II) and represented the collaboration of international vascular specialties involved in the management of patients with peripheral arterial disease (PAD). Since the publication of TASC II, there have been innovations in endovascular revascularization strategies for patients with PAD. The intent of this publication is to provide a complete anatomic lower limb TASC lesion...
54 CitationsSource
#1Michael R. Jaff (Harvard University)H-Index: 89
#2Christopher J. White (UQ: University of Queensland)H-Index: 88
Last. Lars Norgren (Örebro University)H-Index: 61
view all 8 authors...
The Inter-Society Consensus for the Management of Peripheral Arterial Disease (TASC) guidelines were last updated in 2007 (TASC II) and represented the collaboration of international vascular specialties involved in the management of patients with peripheral arterial disease (PAD). Since the publication of TASC II, there have been innovations in endovascular revascularization strategies for patients with PAD. The intent of this publication is to provide a complete anatomic lower limb TASC lesion...
67 CitationsSource
#2Michael R. Jaff (Harvard University)H-Index: 89
#3Christopher J. White (UQ: University of Queensland)H-Index: 88
Last. Lars Norgren (Örebro University)H-Index: 61
view all 8 authors...
The Inter-Society Consensus for the Management of Peripheral Arterial Disease (TASC) guidelines were last updated in 2007 (TASC II) and represented the collaboration of international vascular specialties involved in the management of patients with peripheral arterial disease (PAD). Since the publication of TASC II, there have been innovations in endovascular revascularization strategies for patients with PAD. The intent of this publication is to provide a complete anatomic lower limb TASC lesion...
153 CitationsSource
#1Manesh R. Patel (Duke University)H-Index: 104
#2Michael S. Conte (UCSF: University of California, San Francisco)H-Index: 71
Last. Mitchell W. Krucoff (Duke University)H-Index: 76
view all 30 authors...
The lack of consistent definitions and nomenclature across clinical trials of novel devices, drugs, or biologics poses a significant barrier to accrual of knowledge in and across peripheral artery disease therapies and technologies. Recognizing this problem, the Peripheral Academic Research Consortium, together with the U.S. Food and Drug Administration and the Japanese Pharmaceuticals and Medical Devices Agency, has developed a series of pragmatic consensus definitions for patients being treate...
165 CitationsSource
#1Victor AboyansH-Index: 80
#2Michael H. CriquiH-Index: 152
Last. Diane Treat-JacobsonH-Index: 33
view all 17 authors...
Measurement and interpretation of the ankle-brachial index : a scientific statement from the Ammerican Heart Association
893 CitationsSource