Xuehui Zhang
Peking University
Self-healing hydrogelsBiomedical engineeringNanoparticleComposite materialRegeneration (biology)ChemistryMaterials scienceMesenchymal stem cellIn vitroIn vivoCancellous boneBone tissueGelatinStem cellBone regenerationMembraneChemical engineeringBone healingNanofiberCell biology
47Publications
15H-index
646Citations
Publications 46
Newest
#1Xiaohan Dai (PKU: Peking University)H-Index: 5
#2Boon Chin Heng (PKU: Peking University)H-Index: 4
Last. Xuliang Deng (PKU: Peking University)H-Index: 26
view all 10 authors...
Abstract Macrophage-mediated inflammation compromises bone repair in diabetic patients. Electrical signaling cues are known to regulate macrophage functions. However, the biological effects of electrical microenvironment from charged biomaterials on the immune response for regulating osteogenesis under diabetic conditions remain to be elucidated. Herein the endogeneous electrical microenvironment of native bone tissue was recapitulated by fabricating a ferroelectric BaTiO3/poly (vinylidene fluor...
1 CitationsSource
#1Jiang Shengjie (PKU: Peking University)H-Index: 1
#2Hui Li (CAS: Chinese Academy of Sciences)
Last. Xuliang Deng (PKU: Peking University)H-Index: 26
view all 9 authors...
Source
#1Lei Wang (USTB: University of Science and Technology Beijing)H-Index: 62
#1Lei Wang (USTB: University of Science and Technology Beijing)H-Index: 7
Last. Chun-Sing Lee (CityU: City University of Hong Kong)H-Index: 97
view all 7 authors...
Abstract Self-healing hydrogel systems usually suffer from poor mechanical performance stemmed from weaker and reversible non-covalent interactions or dynamic chemical bonds, which hamper their practical applications. This issue is addressed by adopting a double-crosslinking design involving both dynamic Schiff base bonds and non-dynamic photo-induced crosslinking. This leads to the formation of a special topological structure which simultaneously provide good self-healing capability and enhance...
2 CitationsSource
#1Yan WeiH-Index: 11
#1Yan WeiH-Index: 11
Last. Xuliang DengH-Index: 26
view all 8 authors...
Source
#1Boon Chin Heng (PKU: Peking University)H-Index: 4
#2Xuehui Zhang (PKU: Peking University)H-Index: 15
Last. Xuliang Deng (PKU: Peking University)H-Index: 26
view all 8 authors...
YAP and TAZ are ubiquitously expressed homologous proteins originally identified as penultimate effectors of the Hippo signaling pathway, which plays a key role in maintaining mammalian tissue/organ size. Presently, it is known that YAP/TAZ also interact with various non-Hippo signaling pathways, and have diverse roles in multiple biological processes, including cell proliferation, tissue regeneration, cell lineage fate determination, tumorigenesis, and mechanosensing. In this review, we first e...
3 CitationsSource
#1Tianyi ZhengH-Index: 2
#2Yiqian HuangH-Index: 7
Last. Xiaoping YangH-Index: 44
view all 6 authors...
The process of bone tissue repair and regeneration is complex and requires a variety of physiological signals, including biochemical, electrical and mechanical signals, which collaborate to ensure functional recovery. The inherent piezoelectric properties of bone tissues can convert mechanical stimulation into electrical effects, which play significant roles in bone maturation, remodeling and reconstruction. Electroactive materials, including conductive materials, piezoelectric materials and ele...
2 CitationsSource
#1Boon Chin Heng (PKU: Peking University)H-Index: 4
#2Xuehui Zhang (PKU: Peking University)H-Index: 15
Last. Xuliang Deng (PKU: Peking University)H-Index: 26
view all 8 authors...
The penultimate effectors of the Hippo signaling pathways YAP and TAZ, are transcriptional co-activator proteins that play key roles in many diverse biological processes, ranging from cell proliferation, tumorigenesis, mechanosensing and cell lineage fate determination, to wound healing and regeneration. In this review, we discuss the regulatory mechanisms by which YAP/TAZ control stem/progenitor cell differentiation into the various major lineages that are of interest to tissue engineering and ...
2 CitationsSource
#1Yusi Guo (PKU: Peking University)H-Index: 1
#2Xiaopei Chi (PKU: Peking University)H-Index: 2
Last. Xuliang Deng (PKU: Peking University)H-Index: 26
view all 9 authors...
BACKGROUND Bone marrow-derived mesenchymal stem cell (BMSC) transplantation is considered a promising therapeutic approach for bone defect repair. However, during the transplantation procedure, the functions and viability of BMSCs may be impaired due to extended durations of in vitro culture, aging, and disease conditions of patients. Inspired by spontaneous intercellular mitochondria transfer that naturally occurs within injured tissues to rescue cellular or tissue function, we investigated whe...
5 CitationsSource
#1Lei Wang (USTB: University of Science and Technology Beijing)H-Index: 7
#1Lei Wang (USTB: University of Science and Technology Beijing)H-Index: 2
Last. Chun-Sing Lee (CityU: City University of Hong Kong)H-Index: 97
view all 5 authors...
Abstract Fluorescent carbon nanodots (CNDs) have exhibited attractive potential for biomedical applications due to their intriguing luminescent properties and good biocompatibility. One interesting properties of CNDs is that they typically show different emission colors upon optical excitation using different wavelengths. However, it is still a challenge to obtain emissions covering the entire visible spectrum with comparable intensity with only one type of CND. Herein, CNDs with tunable full-co...
5 CitationsSource
#1Weiwei Liang (PKU: Peking University)H-Index: 4
#2Min Gao (PKU: Peking University)H-Index: 2
Last. Xuliang Deng (PKU: Peking University)H-Index: 26
view all 13 authors...
Integrating multiple pro-osteogenic factors into bone graft substitute is a practical and effective approach to improve bone repair efficacy. Here, Si-Zn dual elements and PLGA microspheres were incorporated into calcium phosphate cement (CPC) scaffolds (PLGA/CPC-Si/Zn) as a novel strategy to synergistically enhance bone regeneration. The incorporation of PLGA microspheres and Si/Zn dual elements within CPC scaffolds improved the setting time, injectability and compressive strength. The PLGA/CPC...
5 CitationsSource
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