Ashley N. Frohman
University of Texas Southwestern Medical Center
OphthalmologyOptical illusionEvidence-based practicePathologyPupillary responseDiffusion MRIEye movementPsychologyNeuroscienceCognitionCognitive neurosciencePolitical scienceCognitive psychologyWorking memoryMultidisciplinary approachMedial longitudinal fasciculusOptic neuritisRetinaTraining (civil)Retinal ganglion cellOptic neuropathyVisual processingAquatic therapyVaccine failureVisual cortexOphthalmoparesisQuality of life (healthcare)Executive dysfunctionTask (project management)Multiple sclerosisRetinalClinically isolated syndromePupillary light reflexWhite matterBrain tissue injuryPopulationNuclear medicineHealth maintenanceCoronavirus disease 2019 (COVID-19)Ocular motorIn patientWater exerciseAquatic exerciseResistance (psychoanalysis)Retinohypothalamic tractMelanopsinAsymmetryPublic relationsComputer scienceAdversaryOperations researchNeutral density filterConditioningPupillary reflexBuoyancyMonocularMedicineEnvironmental engineeringPandemicFractional anisotropyTask switching
Publications 7
Abstract The COVID-19 pandemic has devastated individuals, families, and institutions throughout the world. Despite the breakneck speed of vaccine development, the human population remains at risk of further devastation. The decision to not become vaccinated, the protracted rollout of available vaccine, vaccine failure, mutational forms of the SARS virus, which may exhibit mounting resistance to our molecular strike at only one form of the viral family, and the rapid ability of the virus(es) to ...
#1Meaghan Clough (Monash University)H-Index: 10
#2Paige Foletta (Monash University)H-Index: 2
Last. Joanne Fielding (Monash University)H-Index: 22
view all 7 authors...
BackgroundIt has been suggested that switching ability might not be affected in multiple sclerosis (MS) as previously thought; however, whether this is true under more ‘real-world’ conditions when asymmetry in task difficulty is present has not been ascertained.ObjectiveThe objective of this paper is to examine the impact of task difficulty asymmetry on task switching ability in MS.MethodAn ocular motor (OM) paradigm that interleaves the simple task of looking towards a target (prosaccade, PS) w...
#1Millad J. Sobhanian (University of Texas at Austin)H-Index: 1
#2Rohit Agarwal (University of Texas at Austin)H-Index: 1
Last. Teresa C. Frohman (University of Texas at Austin)H-Index: 37
view all 18 authors...
Background: The Pulfrich phenomenon (PF) is the illusory perception that an object moving linearly along a 2-D plane appears to instead follow an elliptical 3-D trajectory, a consequence of inter-eye asymmetry in the timing of visual object identification in the visual cortex; with optic neuritis as a common etiology. Objective: We have designed an objective method to identify the presence and magnitude of the PF, in conjunction with a cooresponding strategy by which to abolish the effect; with ...
#1Ethan Meltzer (UTSW: University of Texas Southwestern Medical Center)H-Index: 5
#2Peter Sguigna (UTSW: University of Texas Southwestern Medical Center)H-Index: 4
Last. Elliot M. Frohman (UTD: University of Texas at Dallas)H-Index: 84
view all 18 authors...
Importance A neurophysiologic signature of the melanopsin-mediated persistent constriction phase of the pupillary light reflex may represent a surrogate biomarker for the integrity of the retinohypothalamic tract, with potential utility for investigating alterations in homeostatic mechanisms associated with brain disorders and implications for identifying new treatments. Objective To characterize abnormalities of retinal architecture in patients with multiple sclerosis (MS) and corresponding alt...
#1Kenneth Earl Sakaie (Cleveland Clinic)H-Index: 25
#2Masaya Takahashi (University of Texas at Austin)H-Index: 32
Last. Elliot M. Frohman (University of Texas at Austin)H-Index: 84
view all 14 authors...
To test the validity of diffusion tensor imaging (DTI) measures of tissue injury by examining such measures in a white matter structure with well-defined function, the medial longitudinal fasciculus (MLF). Injury to the MLF underlies internuclear ophthalmoparesis (INO).40 MS patients with chronic INO and 15 healthy controls were examined under an IRB-approved protocol. Tissue integrity of the MLF was characterized by DTI parameters: longitudinal diffusivity (LD), transverse diffusivity (TD), mea...
#1Joanne Fielding (Monash University)H-Index: 22
#2Meaghan Clough (Monash University)H-Index: 10
Last. Elliot M. FrohmanH-Index: 84
view all 13 authors...
Cognitive dysfunction is frequently observed in patients with multiple sclerosis (MS), and can have a substantial impact on daily activities and quality of life. In this Review, Fielding and colleagues discuss how ocular motor measures in patients with MS might be used to characterize disruption to wide-ranging networks that support cognitive function, and to track disease progression and responses to novel therapies in these individuals.
#1Ashley N. Frohman (UTSW: University of Texas Southwestern Medical Center)H-Index: 5
#2Darin T. Okuda (UTSW: University of Texas Southwestern Medical Center)H-Index: 25
Last. Elliot M. FrohmanH-Index: 84
view all 9 authors...
Three fundamental principals associated with aquatic therapy differentiate it with respect to exercise on land, and in air. These are buoyancy (reduction in weight of the body within the buoyant medium of water), viscosity (a “drag force” is generated when moving within water, when compared with the same movement in air), and the thermodynamic aspect of water exercise, during which the heat capacity of water is about 1000 times greater than that of an equivalent amount of air; equating to a heat...
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