Thomas G. Bifano
Boston University
OpticsPhysicsEngineeringAdaptive opticsFabricationDeformable mirrorPolishingSurface micromachiningMicroscopyWavefrontActuatorMaterials scienceElectronic engineeringGrindingSpatial light modulatorMicroelectromechanical systemsComputer scienceOptoelectronicsMachiningMicroscope
192Publications
32H-index
3,477Citations
Publications 187
Newest
#1Aleksandar Haber (RIT: Rochester Institute of Technology)
#2Thomas G. Bifano (BU: Boston University)H-Index: 32
We develop a simple and effective control method for accurate control of deformable mirrors (DMs). For a desired DM surface profile and using batches of observed surface profile data, the proposed method adaptively determines both a DM model (influence matrix) and control actions that produce the desired surface profile with good accuracy. In the first iteration, the developed method estimates a DM influence matrix by solving a multivariable least-squares problem. This matrix is then used to com...
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#1Peng Lin (BU: Boston University)H-Index: 6
#2Hongli Ni (BU: Boston University)H-Index: 1
Last. Ji-Xin Cheng (BU: Boston University)H-Index: 83
view all 7 authors...
Stimulated Raman scattering (SRS) microscopy enables the imaging of molecular events on a human subject in vivo, such as filtration of topical drugs through the skin and intraoperative cancer detection. A typical approach for volumetric SRS imaging is through piezo scanning of an objective lens, which often disturbs the sample and offers a low axial scan rate. To address these challenges, we have developed a deformable mirror-based remote-focusing SRS microscope, which not only enables high-qual...
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#3José A. Rivera (University of California, Berkeley)H-Index: 8
#4Manuel A. Mohr (Stanford University)H-Index: 7
ABSTRACT Understanding complex biological systems requires visualizing structures and processes deep within living organisms. We developed a compact adaptive optics module and incorporated it into two- and three-photon fluorescence microscopes, to measure and correct tissue-induced aberrations. We resolved synaptic structures in deep cortical and subcortical areas of the mouse brain, and demonstrated high-resolution imaging of neuronal structures and somatosensory-evoked calcium responses in the...
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#1Cristina Rodriguez (HHMI: Howard Hughes Medical Institute)H-Index: 9
#2Anderson Chen (HHMI: Howard Hughes Medical Institute)H-Index: 1
Last. Na JiH-Index: 29
view all 10 authors...
ABSTRACT null Understanding complex biological systems requires visualizing structures and processes deep within living organisms. We developed a compact adaptive optics module and incorporated it into two- and three-photon fluorescence microscopes, to measure and correct tissue-induced aberrations. We resolved synaptic structures in deep cortical and subcortical areas of the mouse brain, and demonstrated high-resolution imaging of neuronal structures and somatosensory-evoked calcium responses i...
4 CitationsSource
#1Xiaoguang ZhaoH-Index: 16
#2Ke WuH-Index: 3
Last. Xin ZhangH-Index: 98
view all 6 authors...
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#1Chunxu ChenH-Index: 6
#2Yuwei Huang (BU: Boston University)H-Index: 6
Last. Xin ZhangH-Index: 98
view all 7 authors...
Detecting low energy photons, such as photons in the long-wave infrared range, is a technically challenging proposition using naturally occurring materials. In order to address this challenge, we herein demonstrate a micro-bolometer featuring an integrated metamaterial absorber (MA), which takes advantage of the resonant absorption and frequency selective properties of the MA. Importantly, our micro-bolometer exhibits polarization insensitivity and high absorption due to a novel metal-insulator-...
4 CitationsSource
#1Peng Lin (BU: Boston University)H-Index: 6
#2Hongli Ni (BU: Boston University)H-Index: 1
Last. Ji-Xin Cheng (BU: Boston University)H-Index: 83
view all 8 authors...
Operable under ambient light and providing chemical selectivity, stimulated Raman scattering (SRS) microscopy opens a new window for imaging molecular events on a human subject, such as filtration of topical drugs through the skin. A typical approach for volumetric SRS imaging is through piezo scanning of an objective lens, which often disturbs the sample and offers a low axial scan rate. To address these challenges, we have developed a deformable mirror-based remote-focusing SRS microscope, whi...
2 CitationsSource
#1Xiaoguang Zhao (BU: Boston University)H-Index: 16
#2Ke Wu (BU: Boston University)H-Index: 3
Last. Xin Zhang (BU: Boston University)H-Index: 98
view all 6 authors...
Breaking Lorentz reciprocity is fundamental to an array of functional radiofrequency (RF) and optical devices, such as isolators and circulators. The application of external excitation, such as magnetic fields and spatial-temporal modulation, has been employed to achieve nonreciprocal responses. Alternatively, nonlinear effects may also be employed to break reciprocity in a completely passive fashion. Herein, a coupled system comprised of linear and nonlinear meta-atoms that achieves nonreciproc...
3 CitationsSource
#1Devin R. Beaulieu (BU: Boston University)H-Index: 2
#2Ian G. Davison (BU: Boston University)H-Index: 16
Last. Jerome Mertz (BU: Boston University)H-Index: 49
view all 5 authors...
Multiphoton microscopy has gained enormous popularity because of its unique capacity to provide high-resolution images from deep within scattering tissue. Here, we demonstrate video-rate multiplane imaging with two-photon microscopy by performing near-instantaneous axial scanning while maintaining three-dimensional micrometer-scale resolution. Our technique, termed reverberation microscopy, enables the monitoring of neuronal populations over large depth ranges and can be implemented as a simple ...
29 CitationsSource
#1Thomas G. BifanoH-Index: 32
#2Sylvain GiganH-Index: 49
Last. Na JiH-Index: 29
view all 3 authors...
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