Daniel A. Hamstra
Oakland University
Quality of lifeInterquartile rangeCancerInternal medicineRadiologyUrologySurgeryPathologyOncologyUnivariate analysisRandomized controlled trialHazard ratioProstateAndrogen deprivation therapyGliomaMetastasisProstatectomyProstate cancerNuclear medicineCancer researchProportional hazards modelRadiation therapyMedicineBiology
Publications 205
#1Michael P. HaganH-Index: 25
#2Rishabh KapoorH-Index: 4
Last. Joseph J. Nalluri (VCU: Virginia Commonwealth University)H-Index: 5
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Purpose We sought to develop a quality surveillance program for approximately 15,000 US veterans treated at the 40 radiation oncology facilities at the Veterans Affairs (VA) hospitals each year. Methods and Materials State-of-the-art technologies were used with the goal to improve clinical outcomes while providing the best possible care to veterans. To measure quality of care and service rendered to veterans, the Veterans Health Administration established the VA Radiation Oncology Quality Survei...
5 CitationsSource
#1James J. Dignam (U of C: University of Chicago)H-Index: 61
#2Daniel A. Hamstra (UM: University of Michigan)H-Index: 39
Last. Howard M. Sandler (Cedars-Sinai Medical Center)H-Index: 96
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BackgroundIn prostate cancer, end points that reliably portend prognosis and treatment benefit (surrogate end points) can accelerate therapy development. Although surrogate end point candidates have been evaluated in the context of radiotherapy and short-term androgen deprivation (AD), potential surrogates under long-term (24 month) AD, a proven therapy in high-risk localized disease, have not been investigated.Materials and MethodsIn the NRG/RTOG 9202 randomized trial (N = 1,520) of short-term ...
8 CitationsSource
#1Jeff M. Michalski (WashU: Washington University in St. Louis)H-Index: 20
#2Jennifer MoughanH-Index: 32
Last. Howard M. Sandler (Cedars-Sinai Medical Center)H-Index: 96
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Importance Optimizing radiation therapy techniques for localized prostate cancer can affect patient outcomes. Dose escalation improves biochemical control, but no prior trials were powered to detect overall survival (OS) differences. Objective To determine whether radiation dose escalation to 79.2 Gy compared with 70.2 Gy would improve OS and other outcomes in prostate cancer. Design, Setting, and Participants The NRG Oncology/RTOG 0126 randomized clinical trial randomized 1532 patients from 104...
109 CitationsSource
#1James B. YuH-Index: 61
#3MhsH-Index: 1
Last. Daniel A. HamstraH-Index: 39
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#1William C. Jackson (UM: University of Michigan)H-Index: 16
#2Neil DesaiH-Index: 30
Last. Daniel E. Spratt (UM: University of Michigan)H-Index: 50
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Objectives To characterize the frequency and detailed anatomic sites of failure for patients receiving post-radical prostatectomy (RP) salvage radiation therapy (SRT). Materials/Methods A multi-institutional retrospective study was performed on 574 men who underwent SRT between 1986 and 2013. Anatomical recurrence patterns were classified as lymphotropic (lymph nodes only), osteotropic (bone only), or multifocal if both were present. Isolated first failure sites were defined as sites of initial ...
6 CitationsSource
#1Christina H. Son (U of C: University of Chicago)H-Index: 9
#2Daniel A. Hamstra (UM: University of Michigan)H-Index: 39
Last. Stanley L. Liauw (U of C: University of Chicago)H-Index: 28
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Results: Twenty-nine pts (33.7%) of 86 pts were asked to empty their rectum at least once during the course of treatment. For each patient, this occurred in a mean of 2.9 (8.3%) treatments during their course. DVH analysis of the rectal distension CBCTs was done on five of the patients with multiple rectal distension delays (mean of 7 delays; range, 4-12) with results indicated in the attached Table. Conclusions: Rectal emptying when rectal distension is noted on daily CBCT prior to radiation tr...
4 CitationsSource
#1Robert T. DessH-Index: 16
#2William C. JacksonH-Index: 16
Last. Daniel E. SprattH-Index: 50
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BACKGROUND: Stereotactic body radiation therapy (SBRT) for localized prostate cancer involves high-dose-per-fraction radiation treatments. Its use is increasing, but concerns remain about treatment-related toxicity. The authors assessed the incidence and predictors of a global decline in health-related quality of life (HRQOL) after prostate SBRT. METHODS: From 2008 to 2014, 713 consecutive men with localized prostate cancer received treatment with SBRT according to a prospective institutional pr...
12 CitationsSource
#1Daniel A. Hamstra (Texas Oncology)H-Index: 39
#2Neil Mariados (SU: Syracuse University)H-Index: 8
Last. Jeff M. Michalski (WashU: Washington University in St. Louis)H-Index: 73
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Purpose SpaceOAR, a Food and Drug Administration–approved hydrogel intended to create a rectal–prostate space, was evaluated in a single-blind phase III trial of image guided intensity modulated radiation therapy. A total of 222 men were randomized 2:1 to the spacer or control group and received 79.2 Gy in 1.8-Gy fractions to the prostate with or without the seminal vesicles. The present study reports the final results with a median follow-up period of 3 years. Methods and Materials Cumulative (...
159 CitationsSource
#1Daniel A. HamstraH-Index: 39
#2Dhiren ShahH-Index: 4
Last. Neil MariadosH-Index: 8
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69Background: The SpaceOAR phase 3 trial showed that a hydrogel spacer between the prostate and rectum decreased rectal dose and toxicity while improving bowel quality of life (QOL) after image guided prostate IMRT to 79.2 Gy. Here we evaluated dose to penile bulb as well as sexual function on this trial Methods: Sexual QOL was measured with the Expanded Prostate Cancer Index Composite (EPIC) by mean summary scores and the proportion of patients with a minimally important decline (MID) (11 point...
2 CitationsSource