Tamar Kadar
Israel Institute for Biological Research
Internal medicineEndocrinologySurgeryPathologyHippocampal formationChemistryImmunologyCorneaInflammationCorneal neovascularizationSulfur mustardHippocampusBrain damageToxicityAnesthesiaMorris water navigation taskCentral nervous systemMedicineBiologyPharmacology
93Publications
26H-index
2,012Citations
Publications 92
Newest
#1Shlomit Dachir (Israel Institute for Biological Research)H-Index: 19
#2Maayan Cohen (Israel Institute for Biological Research)H-Index: 10
Last. Tamar Kadar (Israel Institute for Biological Research)H-Index: 26
view all 9 authors...
Sulfur mustard induces severe acute and prolonged damage to the skin and only partially effective treatments are available. We have previously validated the use of hairless guinea pigs as an experimental model for skin lesions. The present study aimed to characterize a model of a deep dermal lesion and to compare it with the previously described superficial lesion. Clinical evaluation of the lesions was conducted using reflectance colorimetry, trans-epidermal water loss and wound area measuremen...
9 CitationsSource
#1Yossi Rosman (Medical Corps)H-Index: 12
#2Arik Eisenkraft (MOD: United Kingdom Ministry of Defence)H-Index: 16
Last. Yael Mardor (ATC: Advanced Technology Center)H-Index: 30
view all 17 authors...
Organophosphate intoxication induces neural toxicity as demonstrated in histological analysis of poisoned animals. Diffusion-weighted magnetic resonance imaging (DWMRI) enables early noninvasive characterization of biological tissues based on their water diffusion characteristics. Our objectives were to study the application of MRI for assessment of paraoxon-induced brain damage and the efficacy of antidotal treatments. Seventy-six rats were poisoned with paraoxon followed by treatment with atro...
10 CitationsSource
#1Tamar Kadar (Israel Institute for Biological Research)H-Index: 26
#2Vered Horwitz (Israel Institute for Biological Research)H-Index: 10
Last. Adina Amir (Israel Institute for Biological Research)H-Index: 16
view all 13 authors...
Purpose: Ocular injuries following exposure to the chemical agent sulfur mustard (SM) are characterized by acute corneal erosions and inflammation of the anterior segment that may be followed by delayed Partial Limbal Stem Cell Deficiency (LSCD), expressed clinically by corneal neovascularization and epithelial defects. LSCD may derive from direct destruction of limbal stem cells or indirectly from altered limbal stromal niche. The aim of this study was to investigate the mechanism underlying LS...
28 CitationsSource
#1Shlomit Dachir (Israel Institute for Biological Research)H-Index: 19
#2Maayan Cohen (Israel Institute for Biological Research)H-Index: 10
Last. Tamar Kadar (Israel Institute for Biological Research)H-Index: 26
view all 7 authors...
Background/purpose: Skin exposure to sulfur mustard (HD) results in erythema, edema and severe injury, which take long time to heal and might impose a heavy burden on the health system. Despite many years of research, there is no treatment that prevents the development of the cytotoxic effects of HD causing acute and prolonged damage to the skin. Therefore, it is of great importance to develop treatments that will ameliorate the extent of injury and improve as well as shorten the healing process...
25 CitationsSource
#1Nahum Allon (Israel Institute for Biological Research)H-Index: 10
#2Adina Amir (Israel Institute for Biological Research)H-Index: 16
Last. Tamar Kadar (Israel Institute for Biological Research)H-Index: 26
view all 6 authors...
Guinea pigs (GP) were exposed (head only) in individual plethysmographs to various concentrations of sulfur mustard vapor, determined online, using FTIR attached to flow chamber. The LCt{sub 50} and the inhaled LD{sub 50} were calculated at different time points post exposure. Surviving animals were monitored for clinical symptoms, respiratory parameters and body weight changes for up to 30 days. Clinical symptoms were noted at 3 h post exposure, characterized by erythematic and swelling nose wi...
41 CitationsSource
#1Tamar Kadar (Israel Institute for Biological Research)H-Index: 26
#2Shlomit Dachir (Israel Institute for Biological Research)H-Index: 19
Last. Adina Amir (Israel Institute for Biological Research)H-Index: 16
view all 13 authors...
Sulfur mustard (SM) is a potent vesicant, known for its ability to cause incapacitation and prolonged injuries to the eyes, skin and respiratory system. The toxic ocular events following sulfur mustard exposure are characterized by several stages: photophobia starting a few hours after exposure, an acute injury phase characterized by inflammation of the anterior segment and corneal erosions and a delayed phase appearing following a clinically silent period (years in human). The late injury appea...
85 CitationsSource
#1Ettie Grauer (Israel Institute for Biological Research)H-Index: 15
#2Shira Chapman (Israel Institute for Biological Research)H-Index: 16
Last. Nahum Allon (Israel Institute for Biological Research)H-Index: 10
view all 7 authors...
Freely moving rats were exposed to sarin vapor (34.2 {+-} 0.8 {mu}g/l) for 10 min. Mortality at 24 h was 35% and toxic sings in the surviving rats ranged from sever (prolonged convulsions) through moderate to almost no overt signs. Some of the surviving rats developed delayed, intermittent convulsions. All rats were evaluated for long-term functional deficits in comparison to air-exposed control rats. Histological analysis revealed typical cell loss at 1 week post inhalation exposure. Neuronal i...
43 CitationsSource
#1Tamar KadarH-Index: 26
#2Liat CohenH-Index: 9
Last. Adina AmirH-Index: 16
view all 10 authors...
2 Citations
#1Tamar Kadar (Israel Institute for Biological Research)H-Index: 26
#2David Peri (Israel Institute for Biological Research)H-Index: 2
Last. Rachel Brandeis (Israel Institute for Biological Research)H-Index: 23
view all 8 authors...
The severity and characteristics of retinal injury following laser radiation derived from laser and tissue related factors. We have previously shown that retinal damage following Nd:YAG Q-switched laser radiation in rabbits was related to physical parameters, i.e. energy levels and number of pulses. Yet, an extremely large variability in the severity of the damage was found under similar exposure paradigms, even within the same retina. This emphasizes the role of the biological variables in the ...
Source
#1Tamar Kadar (Israel Institute for Biological Research)H-Index: 26
#2Shlomit Dachir (Israel Institute for Biological Research)H-Index: 19
Last. Adina Amir (Israel Institute for Biological Research)H-Index: 16
view all 7 authors...